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Showing 1 to 20 of 83 for “"methotrexate"”.
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Methotrexate associated toxicity in rheumatoid arthritis
Contains fulltext : 146888.pdf (Publisher’s version ) (Open Access)
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Effect of diet on methotrexate toxicity
… regimens on gastrointestinal toxicity induced by methotrexate (MTX) in rats. Toxicity was determined by severity of anorexia and incidence of diarrhea on d 3 and 4 following an intraperitoneal injection of 20 mg MTX per kg body weight. Rats adapted to a casein-based semipurified diet for 14 d …
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Can curcumin improve the methotrexate based treatment for rheumatoid arthritis?
… major concern due to the side effects involved. Methotrexate (MTX) is currently used as first line treatment due to its ability to modify the rheumatic conditions so that disease progression can be prevented. However, at the same time prolonged exposure to MTX can lead to severe side effects such …
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The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
… the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this …
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Comparative Effectiveness of Methotrexate-Based Disease-Modifying Antirheumatic Drug Combinations for Rheumatoid Arthritis
… with rheumatoid arthritis (RA) initiating methotrexate (MTX); [2] to compare the effectiveness of MTX-based disease-modifying antirheumatic drugs (DMARDs) combinations, including csDMARDs plus MTX, TNFi plus MTX, non-TNFi biologics plus MTX or tsDMARDs plus MTX in RA; [3] to examine the …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
… in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. The main objectives of this thesis were to investigate how methotrexate concentration time data from high dose methotrexate intravenous infusions relate to …
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Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… the developing epigenome. The folate antagonist methotrexate (MTX) was used at lower doses, equivalent to doses for treatment of rheumatoid arthritis, to interrogate the impact of perinatal exposure on the developing epigenome in vitro. Treatment of mouse embryonic stem cells (mESC) and …
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The Effects of Methotrexate on Rat Parotid and Submandibular Glands and Their Secretions (Antineoplastic, Protein, Salivary, Amylase Catecholamines)
… animals were injected intraperitoneally with methotrexate (15 mg/kg) for 3 days. Parotid and submandibular main ducts were cannulated and saliva flow was evoked by either intravenous infusion of acetylcholine (10 to 100 (mu)g/min) or an intravenous injection of bethanechol (100 (mu)g/kg).
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ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ
… EXPERIMENTAL WORK AN ATTEMPT IS MADE TO STUDY METHOTREXATE-INDUCED HEPATOTOXICITY. SIXTY SIX MALE ALBINO RATS WERE USED. OUR RESULTS ARE THE FOLLOWING: 1. METHOTREXATE- INDUCED HEPATOTOXICITY IS ENHANCED BY CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID …
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Studies in the Folate Metabolism of Rats
… chromatography. The effects of an oral dose of methotrexate on folic acid metabolism in adult male Wistar rats were studied. An oral dose of 10 mg/kg body weight methotrexate was administered 24 hours before 2-14C folic acid (76 microgram/kg body weight) dosing. The urinary metabolites …
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The development and evaluation of a self-monitoring and patient-initiated follow-up service for people with rheumatoid or psoriatic arthritis on methotrexate
… arthritis (RA) or psoriatic arthritis (PsA) on methotrexate. Using a mixed methods approach including a randomised controlled trial (RCT) and qualitative semi-structured interviews. The overall aims of this thesis were to design an alternative model of care which could be delivered in …
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Folate transport and drug resistance in the African Trypanosome
… of ‘thyminelessdeath’ was found to account for methotrexate toxicity, as well as the primary mechanism of raltitrexed toxicity. This was confirmed by cell cycle studies demonstrating cell cycle arrest in S phase which could be rescued with thymidine. Transport kinetics of folate and methotrexate …
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Synthesis and pharmacological evaluation of novel anti-tumour prodrugs. Synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics
Methotrexate (MTX) is an antimetabolite anticancer agent that is used in treatment of multiple cancers, such as acute lymphoblastic leukaemia and osteosarcoma. A lack of selective tumour toxicity is one of the major problems associated with MTX chemotherapy, especially when given at high doses, as …
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Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects
… responses to pneumococcal vaccine, whereas methotrexate treated patients showed reduced response to this vaccine regardless of concomitant treatment with TNF antagonists. In contrast, RA patients treated with methotrexate without TNF antagonists had significantly better immune response to …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… agent, such as azathioprine, cyclosporin A or methotrexate. We hypothesised that MG patients with the C>G SNP when treated with immunosuppressant drugs, may have lower DAF protein levels contributing to increased susceptibility to autologous complement-mediated damage at their EOMs. This study …
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Establishment and characterisation of chemoresistant osteosarcoma cell lines by single and multi-agent induced strategies
… of cisplatin, doxorubicin and high-dose methotrexate is the standard treatment for most patients. Surgery combined with chemotherapy has improved the survival rate for osteosarcoma patients to 60% - 70%. However, most of the patients with metastatic or recurrent osteosarcoma have poor …
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Treatment pathways and economic analysis of treatment for severe psoriasis
… for moderate-severe psoriasis (cyclosporin, methotrexate, systemic retinoids and photochemotherapy) were performed. Randomised controlled trials were located systematically by electronic searching, hand searching and personal communications. Data on trial characteristics and outcomes were …
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