Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 194 for “"method development"”.
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Method Development Towards Catalytic Transformations of Reactive Intermediates
… of each component of the reaction, and develop methods that were chemo- and regioselective with limited side reactions to provide a platform for further diastero- and enantioselective processes. We were able to accomplish such under broad Lewis acid catalyzed methods. Secondary goals, once a …
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Mammalian genome engineering: Fundamental investigation and method development
… genome engineering. Chapter 4 describes a method that I developed to safeguard the most widely used genome-editing technology, CRISPR/Cas9. CRISPR/Cas9 are modular DNA-binding proteins that can recognize a customized DNA-sequence when programmed with a complementary gRNA molecule. The …
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METHOD DEVELOPMENT FOR THE ANALYSIS OF PROTEINS AND SMALL
… in conjunction with powerful detection methods make possible the quantitation of large and small molecules important in environmental science, food science, pharmaceutical, and medical matrices. Many of these separations utilize instrumental methods such as capillary electrophoresis (CE) …
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Tannin geochemistry of natural systems: method development and application
… in natural products. This thesis presents the development of a new method for molecular-level condensed tannin analysis, a survey of source tissues, and a geochemical application focussed on mangrove leaf diagenesis in a tropical estuary.The developed method consists of acid hydrolysis (HCl) of …
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Obesity and endothelial dysfunction: mechanisms, method development and interventions
… develop the contrast enhanced ultrasound (CEU) method in our laboratory for measuring muscle MBV of the human forearm, and use CEU to measure the MBV response to an oral glucose tolerance test (OGTT). No differences were observed in exercise-induced increases in MBV or resting MBV between …
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Mercury in hair: Method development and application to population studies.
… to assess whether it presents a danger to the development of children in the UK.The development and optimisation of a digestion procedure for the determination of total mercury in hair is described. The procedure chosen consists of the microwave digestion of 0.2-0.5g hair with 2 ml HNO3 and 1 …
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Method development for analysis of polyamines and metabolites by mass spectrometry
<p>A rapid method was developed for the quantitative analysis of N, N'hexamethylenebisacetamide (HMBA) and its deacetylated metabolites, N-acetyl-1, 6- diaminohexane (NADAH) and 1, 6-diaminohexane (DAH). The method used flowinjection liquid chromatography (LC)-atmospheric pressure chemical …
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Palladium-Catalyzed Alkenylsilanol Cross -Coupling Reactions: Method Development and Mechanistic Analysis
The transmetalation mechanism was examined through the natural abundance 13C NMR kinetic isotope effect (KIE) studies. This provided evidence for either palladium-olefin complexation or a Heck-type carbometalation as the turnover-limiting step for these cross-coupling reactions.
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Molecular simulation method development and implementation for fuel cell catalyst layers
… coarse-grained molecular dynamics method, to model such thin film confined from both sides. Our results summarised in Chapter 2 reveal a confinement-induced water clustering as well as a diffusivity anisotropy increasing with decreasing film thickness, confirming that the behaviour …
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Digestion of inositol phosphates by dairy cows: Method development and application
… and accurate phytate (Pp) quantification method. The objective of the first study was to develop a robust, accurate, and sensitive method to extract and quantify phytate in feeds, ruminant digesta and feces. Clean-up procedures were developed for acid and alkaline extracts of feed, …
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Organocobalt Mediated Cyclizations and Biochemically Inspired Isomerizations - Method Development and Mechanistic Studies.
This dissertation describes research on a wide array of topics. Chapter one follows closelya review publication from our group which details the synthetic and mechanistic progress in the literature from the early to mid-2010s of the Pauson-Khand Reaction(PKR). Chapter two focuses on our work …
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Spatio-Temporal Patterns of Biodiversity and their Drivers - Method Development and Application
… zu erfassen. Daher ist es überaus wichtig, Methoden für eine umfassende Erfassung und Bewertung von Biodiversität zur Verfügung zu stellen. Aufgrund der Geschwindigkeit des Biodiversitätsverlustes sollten diese ebenso repräsentativ wie pragmatisch sein. Wenn Biodiversität auf …
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Method Development For Concentration Measurements of SVOCs and Analysis of Ambient Samples
… yield and environmental fate. Recently, a new methodology that allows sampling and analysis of the total (gas phase and PM) concentration of SVOCs in the atmosphere has been developed and tested on a class of SVOCs, namely, nitrophenols (Busca, 2010; Moukhtar et al., 2011; Saccon et al., 2013). …
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Ecological method development for detecting N-nitrosodimethylamine in water using HPLC-PDAD
… high-performance liquid chromatographic method with photo-diode array detection (HPLC-PDAD) was investigated to detect sub-parts per billion concentrations of N-nitrosodimethylamine (NDMA) in drinking water and environmental water samples. This presents a practical and “green” option to …
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