Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"methionine sulfoxide reductase"”.
-
Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
… on elevated dopamine and 14-3-3 levels in the methionine sulfoxide reductase A (MsrA) knockout mouse brain, as well as decreased αSyn degradation in MsrA KO yeast cells. Hence, this study will focus on the interactions among MsrA, αSyn degradation, 14-3-3 proteins, and Ub. Here we show that …
-
Free methionine sulfoxide reductase and its contributions to environmental stress response in Komagataeibacter hansenii
… bacteria. In this thesis, the role of free methionine-R-sulfoxide reductase (MsrC) was investigated through comparative analysis of the wildtype (WT) K. hansenii, an msrC-deficient mutant (ΔmsrC), and a complemented strain using the shuttle plasmid pUCD2. The ΔmsrC mutation greatly affects …
-
Characterization of a carbon source-dependent, phytohormone-responsive, free methionine-(R)-sulfoxide reductase from Komagataeibacter hansenii
… thesis, the functional role of a putative free methionine sulfoxide reductase (MsrC) was characterized using a knockout mutant. The growth of the mutant was greatly affected by the presence of ethylene, abscisic acid and indole-3-acetic acid while oxidative stress increased BC production. …
-
Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… in the 3NP treated rats. In a separate study, methionine sulfoxide reductase A (MsrA) mice, which model oxidative stress, have been reported to have chronically high dopamine levels relative to control mice. Additionally, these high levels parallel an increased presynaptic dopamine release when …
-
INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
… maintain homeostatis, living organisms have the methionine sulfoxide reductase system, which reduce both free and protein bound Met(O) back to methionine (Met) in the presence of thioredoxin. Oxidized Trx is inactive and unable to bind to ASK1 thereby activating ASK1 and causing cell death via …
-
Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
… oxidize actin on its conserved methionine-44 and methionine-47 residues, inducing both F-actin disassembly and altered actin polymerization. Our work has also revealed that this Mical-mediated actin regulatory process is reversible by a specific methionine sulfoxide reductase …
-
Characterization of the thioredoxin system in Methanosarcina mazei
Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, …