Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"methicillin-resistant S. aureus (MRSA)"”.
-
The molecular characterisation of methicillin-resistant Staphylococcus aureus from hospitals in Cape Town
… are prerequisite for establishing control over methicillin-resistant S. aureus (MRSA) in the hospital setting; however, there is currently a paucity of molecular epidemiological data available on MRSA from South Africa. A molecular characterisation of one hundred MRSA isolates collected between …
-
Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa
Background: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia (SAB), however, has not been well documented in children in South Africa. Methods: A retrospective study was conducted at a children's hospital in …
-
Pathogenic Potentials of Clinical MRSA Isolates from the UK and Nigeria: A Comparative Study
Methicillin-resistant S. aureus (MRSA) are a major problem in both clinical and community settings. They have the potential to produce invasive infections and are now most often multi-resistant. There is an indication that African S. aureus may be more virulent than those from other parts of the …
-
Characterization of Vancomycin Resistance in Staphylococcus Aureus
In the past decade, Staphylococcus aureus has developed two distinct vancomycin resistance mechanisms. First, the bacterium is capable of generating a thickened, poorly crosslinked cell wall that creates false targets. These targets cause vancomycin to bind at the periphery of the thickened …
-
The infected knee arthroplasty
… haematogenous infections it was Staphylococcus aureus. Only 1 case of methicillin resistant S. aureus (MRSA) was found, while resistance to methicillin was common in CNS and increased during the study period. Two-stage revision arthroplasty was performed in 60% and one-stage in 9%. Almost 30% …
-
A genome wide approach to identify factors asociated with vancomycin non-susceptibility in Staphylococus aureus
… the standard of care in the treatment of Methicillin-Resistant S. aureus (MRSA) infections and widespread use has driven antimicrobial resistance. While fully resistant S. aureus strains have been identified, vancomycin-intermediate S. aureus (VISA) and heterogeneous …
-
A genome wide approach to identify factors asociated with vancomycin non-susceptibility in Staphylococus aureus
… the standard of care in the treatment of Methicillin-Resistant S. aureus (MRSA) infections and widespread use has driven antimicrobial resistance. While fully resistant S. aureus strains have been identified, vancomycin-intermediate S. aureus (VISA) and heterogeneous …
-
An investigation into the use of High-Intensity Narrow Spectrum light as a decontamination technology
… was particularly toxic to Staphylococcus aureus, methicillin-resistant S. aureus (MRSA) and Acinetobacter baumannii, although it elicited either no effect or a bacterio-static effect in other tested bacteria. HINS-light is known to be less germicidal than pulsed ultraviolet (PUV) light …
-
Bioactive Peptides as Antibacterial Agents and Visual Transduction
… as a potential therapeutic agent to treat severe methicillin resistant S. aureus (MRSA) infections via reverse sequencing and peptide stapling to enhance its compacity to penetrate lipid interfaces, improve helicity, and metabolic stability. Preliminary results support that these new BPs are …
-
Application of Essential Oil Compounds and Bacteriophage to Control Staphylococcus aureus
<p>Staphylococcus aureus is one of the most important pathogens, causing various diseases in humans and animals. In addition, S. aureus is a common foodborne pathogen. As methicillin- resistant S. aureus (MRSA) becomes increasingly prevalent, controlling this pathogen in animals and humans with …
-
The management and outcomes of Staphylococcus aureus Bacteraemia at a South African referral hospital: A prospective observational study
Staphylococcus aureus is a major human pathogen found worldwide, causing a wide variety of clinical infections. This ranges from skin and soft tissue infections to lifethreatening invasive disease, such as S. aureus bacteraemia (SAB). Despite being a common cause of both community-acquired and …
-
Structural characterization of superbug proteins involved in regulating beta-lactam resistance
… The notorious resistance of Staphylococcus aureus primarily stems from the production of β-lactamases and PBP2a, a low-affinity PBP which confers broad-spectrum β-lactam resistance in methicillin-resistant S. aureus (MRSA) strains. Expression of these resistance determinants is controlled …
-
Genomic insights into the host range and interspecies transmission dynamics of Staphylococcus aureus
Staphylococcus aureus is an important human bacterial pathogen with a wide host range, including livestock, companion, and wild animal species. Genomic and epidemiological studies show that S. aureus can freely transmit between different species, with some of these transmissions resulting in …
-
Antibiotic Resistance Profiles and Population Structure of Healthcare-associated and Community-associated Staphylococcus aureus isolated in Fort Portal, Western Uganda
… focused on the evaluation of Staphylococcus aureus, a commensal bacterium carried by roughly 30% of the human population commonly in the nasopharynx and/or on skin. S. aureus also acts as a major human pathogen frequently associated with nosocomial infections where the skin has been broken, …
-
Identification of MRSA-specific peptides and expression of peptide containing recombinant proteins for targeted photodynamic therapy
Staphylococcus aureus (S. aureus) is an opportunistic pathogen capable of causing infection at multiple sites and is one of the predominant organisms found in chronic wounds, such as venous ulcers. Furthermore, there is an ever-increasing prevalence of multi-drug resistant strains, such as …
-
Detección y caracterización de péptidos con actividad antimicrobiana en aislados de Staphylococcus. Aplicación al ámbito agroalimentario y en salud pública
… can be opportunistic pathogens, especially S. aureus. Currently, Staphylococcus is gaining attention as a bacteriocin-producing genus, especially coagulase-negative species. In this work, the antimicrobial activity (AA) of 1205 staphylococcal isolates, both coagulase-positive (CoPS, n=284) and …
-
Investigation of a novel iron-uptake system and other genomic features in mecC Staphylococcus aureus
Staphylococcus aureus (S. aureus) is a significant pathogen that causes a wide variety of disease in humans and animals. Methicillin resistant S. aureus (MRSA) isolates carrying mecC, the gene that confers resistance to the antibiotic, have been isolated from humans but also from diverse animal …
-
Nasopharyngeal carriage with Staphylococcus aureus in healthy children during the first year of life - The Drakenstein Child Health study
Background: Staphylococcus aureus carriage is a risk factor for subsequent infections. Data on the prevalence, determinants, population structure and molecular epidemiology of S. aureus nasal carriage among healthy African populations are scarce, especially during infancy. The different S. aureus …
-
Staphylococcus aureus en animales de vida libre y medioambiente. Resistencia a antimicrobianos, virulencia, líneas genéticas circulantes y genómica comparativa
Staphylococcus spp., especially S. aureus species, are part of the normal microbiota of healthy humans and animals, but it can also be opportunistic pathogens. Methicillin-resistant S. aureus (MRSA) is a serious health problem since it shows resistance to almost all β-lactam antibiotics. In 2005, …
-
Development of an Optical Fiber Biosensor with Nanoscale Self-Assembled Affinity Layer
… sensitivity and specificity of the biosensor to methicillin- resistant Staphlococcus aureus (MRSA). The data we obtained have shown a sensitive threshold at as low as 102 cfu/ml with pure culture samples. A typical MRSA antibody-based biosensor assay with MRSA sample at this concentration has …