Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"methicillin-resistant S. aureus"”.
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Daptomycin versus Vancomycin for Empiric Treatment of Methicillin-Resistant S. aureus among Hospitalized Patients: An Institutional Cost-Breakpoint Analysis
Background: Bacteremia caused by methicillin-resistant Staphylococcus aureus is associated with increased hospitalization days, costs, and mortality. Daptomycin was shown to be noninferior to vancomycin in a phase III clinical trial; however the study was limited by low rates of MRSA infection and …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… levels change over the whole growth curve of S. aureus, from senescence to logarithmic growth and back to senescence. We first extended our established ion-pairing agent-based LC-MS/MS method for detecting UDP-linked intermediates, including energy-rich nucleotides (ATP, etc.) (unpublished). In …
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The molecular characterisation of methicillin-resistant Staphylococcus aureus from hospitals in Cape Town
… are prerequisite for establishing control over methicillin-resistant S. aureus (MRSA) in the hospital setting; however, there is currently a paucity of molecular epidemiological data available on MRSA from South Africa. A molecular characterisation of one hundred MRSA isolates collected between …
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Investigation of the YefM-YoeBSa toxin-antitoxin systems as novel antibacterial targets
The rise and spread of drug-resistant pathogens has created a critical need for the continued discovery and development of new antibacterial compounds. Bacterial toxin-antitoxin (TA) systems consist of a toxin capable of arresting cell growth and an antitoxin that binds to and inhibits the toxin …
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The prevalence of toxin-antitoxin systems and their tractability as novel antimicrobial targets
… of TA systems in clinical isolates of vancomycin-resistant enterococci and methicillin-resistant S. aureus to validate TA systems as an antibacterial target. Two TA systems, Axe-Txe and RelBE, were found to be common among the pathogenic bacteria surveyed and were therefore further investigated. A …
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Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa
Background: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia (SAB), however, has not been well documented in children in South Africa. Methods: A retrospective study was conducted at a children's hospital in …
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Pathogenic Potentials of Clinical MRSA Isolates from the UK and Nigeria: A Comparative Study
Methicillin-resistant S. aureus (MRSA) are a major problem in both clinical and community settings. They have the potential to produce invasive infections and are now most often multi-resistant. There is an indication that African S. aureus may be more virulent than those from other parts of the …
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Two strategies to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci: comparative transcriptomic of two DAP-R/DAP-S MRSA isogenic couples and CRISPR system characterization of pathogenic S. epidermidis
… to better know the features of Multi-Drug Resistant (MDR) bacteria to develop new strategies to overcome the antibiotic resistance. Among the most common bacteria capable to infect humans and become resistant to antibiotics, the members of the genus Staphylococcus are the etiological agents …
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Synthesis and antibacterial evaluation of diverse small molecules
… Pseudomonas aeruginosa and Staphylococcus aureus. First we extend organocatalysis to the field of diversity-oriented synthesis as a powerful means to generate molecular diversity and complexity in small molecule screening collections. We then study a family of potential biofilm inhibitors …
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Biosynthesis of the antimicrobial peptide epilancin 15X
… against several pathogenic bacteria, including methicillin-resistant S. aureus and vancomycin-resistant Enterococci. Epilancin 15X contains an unusual N-terminal lactate group (Lac) that could be important for its bioactivity. To understand its biosynthesis, the epilancin 15X gene cluster was …
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The infected knee arthroplasty
… haematogenous infections it was Staphylococcus aureus. Only 1 case of methicillin resistant S. aureus (MRSA) was found, while resistance to methicillin was common in CNS and increased during the study period. Two-stage revision arthroplasty was performed in 60% and one-stage in 9%. Almost 30% …
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Carriage rate of staphylococcus aureusamong healthcare workers at the University Teaching Hospital in Lusaka
Staphylococcus aureus is a frequent cause of hospital-acquired infections worldwide. The carriage of S. aureus among healthcare workers has been associated with transmission of the bacterium to susceptible patients. The aim of this study was to determine the carriage rate, antimicrobial …
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Carriage rate of staphylococcus aureusamong healthcare workers at the University Teaching Hospital in Lusaka
Staphylococcus aureus is a frequent cause of hospital-acquired infections worldwide. The carriage of S. aureus among healthcare workers has been associated with transmission of the bacterium to susceptible patients. The aim of this study was to determine the carriage rate, antimicrobial …
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Characterization of Vancomycin Resistance in Staphylococcus Aureus
In the past decade, Staphylococcus aureus has developed two distinct vancomycin resistance mechanisms. First, the bacterium is capable of generating a thickened, poorly crosslinked cell wall that creates false targets. These targets cause vancomycin to bind at the periphery of the thickened …
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Investigation of bioactive scaffolds as antimicrobials
… incidence and prevalence of antibiotic-resistant bacterial strains is a worrying global issue. Since the ‘Golden Age’ of antibiotic drug discovery, identifying compound classes with distinct mechanisms of action has proved to be a difficult task. An additional approach to overcoming …
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Application of Essential Oil Compounds and Bacteriophage to Control Staphylococcus aureus
<p>Staphylococcus aureus is one of the most important pathogens, causing various diseases in humans and animals. In addition, S. aureus is a common foodborne pathogen. As methicillin- resistant S. aureus (MRSA) becomes increasingly prevalent, controlling this pathogen in animals and humans with …
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Detection of virulence genes and antimicrobial resistance genes in staphylococci isolated at Malamulo hospital in Malawi.
… coa genes were used to detect and identify S. aureus species. Disc diffusion susceptibility test was used to determine antimicrobial susceptibility levels. PCR was performed to detect antimicrobial resistance genes (mecA, ermA, ermB, ermC, tetK, tetL, tetM and tetO) and virulence genes (PVL …
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Detection of virulence genes and antimicrobial resistance genes in staphylococci isolated at Malamulo hospital in Malawi.
… coa genes were used to detect and identify S. aureus species. Disc diffusion susceptibility test was used to determine antimicrobial susceptibility levels. PCR was performed to detect antimicrobial resistance genes (mecA, ermA, ermB, ermC, tetK, tetL, tetM and tetO) and virulence genes (PVL …
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A genome wide approach to identify factors asociated with vancomycin non-susceptibility in Staphylococus aureus
… the standard of care in the treatment of Methicillin-Resistant S. aureus (MRSA) infections and widespread use has driven antimicrobial resistance. While fully resistant S. aureus strains have been identified, vancomycin-intermediate S. aureus (VISA) and heterogeneous …
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A genome wide approach to identify factors asociated with vancomycin non-susceptibility in Staphylococus aureus
… the standard of care in the treatment of Methicillin-Resistant S. aureus (MRSA) infections and widespread use has driven antimicrobial resistance. While fully resistant S. aureus strains have been identified, vancomycin-intermediate S. aureus (VISA) and heterogeneous …
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