Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 109 for “"metazoan"”.
-
Neuropeptidomics Across Metazoan Life
Every neuron in our brain is bathed in a sea of diverse signaling molecules, including peptides. It is well known that neuropeptides, acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, …
-
Molecular phylogenetics of the Metazoan clade Lophotrochozoa
… relationships between taxa within the metazoan clade Lophotrochozoa. Chapter 1 presents an introduction to phylogenetics of the Metazoa and the clade Lophotrochozoa. Chapter 2 analyzes higher level relationships between the major groups within the phylum Mollusca using sequences of the …
-
On connections between metazoan cellular metabolism and cell size
All animal cells maintain cell size homeostasis, where cell growth (increase in size) is balanced with proliferation (reduction in size via cell division). Yet, different cell types have different sizes and there are physiologically relevant situations where animal cells undergo major cell size …
-
Bridging the gap between microbial and metazoan evolutionary history
… microbial fossils and biomarkers. Conversely, metazoans (animals) emerged relatively recently and have deposited a thorough archive of their existence in the rock record. The ancient shared ancestry of these two groups presents an opportunity to leverage the rich metazoan fossil record to …
-
Evolutionary conservation and characterization of the metazoan amino acid response
… identify and characterize the ISR in the basal metazoan, Nematostella vectensis, revealing that the core components of the mammalian ISR were present over 550 million years ago in the common ancestor of cnidarians and bilaterians. Additionally, our lab has discovered a novel branch of the AAR …
-
Evolutionary conservation and characterization of the metazoan amino acid response
… identify and characterize the ISR in the basal metazoan, Nematostella vectensis, revealing that the core components of the mammalian ISR were present over 550 million years ago in the common ancestor of cnidarians and bilaterians. Additionally, our lab has discovered a novel branch of the AAR …
-
The Wnt Casade and Stem Cell Fate in a Basic Metazoan
… fate and maintenance within many of the chordate metazoans. This work served to establish if such a role has already evolved early in metazoan phylogeny by using Hydractinia, a primitive eumetazoan as a model. This work established the presence of a WNT pathway in the hydrozoan Hydractinia. The …
-
Microbial and metazoan effects on nutrient dynamics during leaf decomposition in streams
I investigated the drivers of nutrient cycling by heterotrophic microbes during leaf decomposition in streams. My research addressed two overarching questions: 1) how do exogenous and endogenous factors interact to drive microbial nitrogen (N) cycling during organic matter decomposition in stream …
-
Understanding the evolution of the apical organ in the early branching metazoan, Nematostella vectensis
… on Nematostella vectensis. As an early-branching metazoan, N. vectensis is a unique model for studying evolution of the apical organ, and subsequently the origins of the nervous system. Through generating tissue-specific transcriptomes and integrating this data with an existing single-cell RNA …
-
Analysis of metazoan DNA replication initiation using Drosophila gene amplification as a model system
Gene amplification in Drosophila follicle cells is an excellent model to study origin specification and developmental regulation of DNA replication in vivo. We mapped all follicle cell amplicons using a comparative genomic hybridization strategy and identified two new amplicons. We determined the …
-
Environmentally Influenced Duplication Patterns Followed by Functional Shifts Fueling the Evolution of Metazoan Sensory Systems
In this thesis, some of the methods by which animals use their sensory systems to interact with their environment have been extensively studied. How gene duplications have played an important role in sensory evolution by duplication followed by functional shifts resulting in neofunctionalisation …
-
Gene amplification in Drosophila ovarian follicle cells as a developmental strategy and model for metazoan DNA replication
… as such, is a powerful system for the study of metazoan DNA replication. Furthermore, the nature of the ovaries, with egg chambers of various ages arrayed in the order they were created, coupled with the use of cell biology, allows for the visualization of gene amplification at multiple …
-
Directed evolution in human cells via adenoviral replication
… of biomolecules that reliably function in metazoan cells is imperative for both basic biological research, and therapeutic development. Typically, researchers turn to directed evolution either in vitro, in bacteria, or in yeast, to mutate, select, and amplify biomolecules of interest (BOls) …
-
A survey of the metazoan parasite assemblage of snoek, Thyrsites atun (Euphrasen, 1791), off South Africa with an assessment of host-parasite relationships and potential biological tags
… underestimated. This study aimed to survey the metazoan parasite community of snoek off South Africa, assess host-parasite relationships and evaluate the potential of parasites as biological tags for stock structure studies. Examination of 210 snoek (FL 411 - 1040 mm) revealed them to be host to …
-
Comparative genomics of early animal evolution
… data sets has revolutionized our views of metazoan relationships over the past decades, but on the other hand, a number of nodes on the metazoan tree remain uncertain. Uncertainty is particularly high with reference to the taxa generally named “early branching metazoans”. Unfortunately, …
-
The Growth and Ecology of Upper Cambrian Microbialite Biostromes from the Notch Peak Formation in Utah
… sponge-microbial ‘stromatolites,’ a new type of metazoan bio-structure that has only been described from the Carboniferous and Triassic periods. This discovery has important implications when reconstructing middle to upper Cambrian reef-building communities, as these periods are assumed to have a …
-
Alternative Splicing Expands Spatiotemporal Expression Complexity of Arthropod N -Cadherin
Metazoan development requires mechanisms to generate cells with diverse functions. Cellular diversity is dictated by complex patterns of molecular expression, originating from dynamic spatiotemporal regulation of transcriptomes. Both gene duplication and alternative splicing have been proposed as a …
-
Transcriptional regulation of the piRNA pathway in animal ovarian germ cells
… piRNA pathway components within the gonads of metazoan species remain largely unexplored. In contrast to the male germline piRNA pathway, which in mice is known to be activated by the testis-specific transcription factor A-MYB, the nature of the ovary-specific gene-regulatory network driving …
-
Evolution des programmierten Zelltods
The simple metazoan Hydra does posses two genes for caspases: Caspase 3A and caspase 3B. We generated antibodies against these caspases. By immunofluorescence staining and cell fractionation we demonstrated that both caspases are localized in mitochondria in vivo.Caspase 3A is a constitutively …
-
Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
… copper acquisition in the development of metazoan organisms via as yet uncharacterized mechanisms. The early lethality of the Ctr1 knockout mouse has made it difficult to study the functions of copper and Ctr1 proteins in metazoan development and physiology. Drosophila melanogaster, a …
Page 1 of 6