Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"metastatic stage"”.
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Prevalence of Pik3ca-Mutations and Response to First-Line Endocrine Therapy in a Population of Bulgarian Patients with HR(+) HER2(–) Metastatic Breast Cancer // Честотата на PIK3CA-мутацията и отговорът към първа линия ендокринна терапия в популацията от български пациентки с HR(+)HER2(-) метастазирал карцином на гърдата
The study examined 250 patients with metastatic HR(+)/HER2(–) breast cancer, diagnosed and treated between January 2016 and November 2022 at three hospitals in Bulgaria (Nadezhda Hospital - Sofia, St. Marina University Hospital – Varna, Acibadem City Clinic Hospital Tokuda – Sofia). The prevalence …
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Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
… analyzed GR signaling in enzalutamide resistant metastatic prostate cancer cell lines. We assessed protein levels of AR and GR as well as mRNA expression of various AR targets. Our results illustrate the expected downregulation of AR and upregulation of GR in enzalutamide resistant cells. …
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Suppression of the Ubiquitin Ligase Function of FBXW7 Accelerates Metastatic Progression of Pancreatic Ductal Adenocarcinoma
… because it is usually diagnosed at an advanced/metastatic stage. Dysregulation of protein stability and degradation has been associated with uncontrolled proliferation and genomic instability, promoting cancer progression to metastasis. One of the major regulators of protein degradation is the …
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
… and disappointing results of chemotherapy at metastatic stage make melanoma a major medical challenge. The last decades have shown great progress in discovery and description of transporters that confer drug resistance or mediate inflammatory tumour response like the multidrug …
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ROLES OF 15-LIPOXYGENASE-2 (ALOX15B) IN SUPPRESSION OF TUMOR FORMATION, METASTASIS, AND SENSITIVITY TO CHEMOTHERAPY
… cells. The expression of 15-LOX-2 lost in the metastatic stage of prostate tumor compared to the primary and benign tumor. To investigate the role of 15-LOX-2 in a highly metastatic prostate tumor, we overexpressed 15-LOX-2 in PC3MM cell line using Lenti-X Tet-on advanced inducible expression …
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Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines.
… with CRC, patients suffering from the later metastatic stage of the disease have a 5-year survival rate of only 14%. To enhance the current treatment options, bisnaphthalimides (BNIPs) were developed as a new group of chemotherapeutic agents. Presenting promising results in vitro against …
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Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
… Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour …
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Development of a prognostic and predictive tool for chemotherapy response in patients with locally advanced and metastatic pancreatic adenocarcinoma
… majority of patients diagnosed at an advanced or metastatic stage—well beyond the window for curative surgical intervention. For these individuals, systemic chemotherapy remains the cornerstone of treatment. However, the absence of validated prognostic biomarkers, a lack of consensus on optimal …
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Circulating Tumour DNA in Localised Urological Cancers
… a TP53 specific panel was applied to men with metastatic disease, to demonstrate that clones containing TP53 mutations, which are dominant in at the metastatic stage were present in historical prostatectomy samples taken when then patient was believed to have localised disease only. …
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Studies into the relationship between GPCR43 and BuA-induced effects on colorectal cancer.
… line to represent adenocarcinoma, carcinoma and metastatic stage of disease. (2) Investigating the expression of GPCR43 with manipulated nutrient media and different levels of cell confluence. (3) Exploring GPCR43 expression in normal and malignant human patient biopsies. (4) Determining if the …
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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… 75% of skin cancer deaths. Once diagnosed at the metastatic stage, it has a very poor prognosis with a median survival rate of 6 months and a 5-year survival rate of less than 5%. In addition, melanoma has become an important public health hazard owing to its rising incidence, which has been well …