Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 87 for “"metastatic potential"”.
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Phospho-regulation and metastatic potential of Murine Double Minute 2
… and independent functions of Mdm2 that represent potential new avenues for therapeutic intervention.
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Inhibiting metastatic potential: an analysis of migratory body formation in chondrosarcoma
… In our research group, we have identified a potential route through which metastasis might occur. Our in vitro observations with CHS cell-line SW1353 have shown that spheroids which we call migratory bodies (MB) can detach from the monolayer in our cell culture plates and remain suspended in …
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Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes
… patients’ morbidity and mortality. The bone-metastatic cancer cells interact with cells in the bone to disrupt the bone remodeling balance, causing reduced bone quality and other complications while facilitating tumor growth. Bone remodeling cells can be regulated by osteocytes, the major …
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The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer
Obesity is a major global health concern due to its steadily increasing rates and significant contribution to numerous diseases, including cancer. Ovarian cancer specifically, is associated with a 30% increased risk with obesity, although the mechanisms for this are unknown. Waist-to-hip ratio has …
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Evaluating the Effects of Fluid Shear Stress on Ovarian Cancer Progression and Metastatic Potential
… of the physical environment and its potential links to ovarian cancer progression and metastatic potential.
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… metastasis may lead to new therapies to prevent metastatic cancer. We used a set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low …
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The Temporal and Contextual Relationship of NRF2 Activation and Cancer
… as well as the involvement of NRF2 in metastatic potential of melanoma and NSCLC. In the context of the light side of NRF2, pharmacological induction of NRF2 using bixin increased cellular glutathione levels which in turn combatted oxidative stress and mitigated radiation-induced …
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Development of Glyco-RNA Technologies & Elucidating the Roles of miRs in Head and Neck Cancer Metastasis
… on miR-206 and its regulation of TAGLN2 and metastatic potential in head and neck squamous cell carcinoma. Metastasis is a critical factor for survival in head and neck cancers with patients often presenting or developing metastatic tumors during clinical presentation or treatment. It is …
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… rate, but this rate drops to 33% for men with metastatic disease. A better understanding of the metastatic process is needed to develop better therapies for PCa. Aberrant activation of protein tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous …
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Discovery of prognostic biomarkers from the prostate cancer membrane proteome using bioorthogonal chemistry
… the stages of cancer progression. The metastatic potential of the established prostate and breast cancer cell lines used in the study was confirmed in the scratch wound and Boyden chamber assays and by demonstrating a correlation with increased expression of vimentin, loss of PTEN …
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The effect of hypoxia and 3D culture conditions on heterogeneous ovarian cancer spheroids
… makers to promote ovarian cancer aggressive potential. Hypoxia and spheroid formation decreased ovarian cancer cells growth but increased the chemoresistance, which leads to the promotion of aggressiveness and metastasis potential of ovarian cancer. SVF co-cultured spheroids further increased …
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RNA Deregulation in Metastatic Breast Cancer
… with the majority of deaths associated with metastatic spread of tumors to distal organs. The metastatic process involves multiple sequential steps including invasion of the surrounding stroma, intravasation into lymph or blood vessels, survival during transport with successful evasion of the …
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The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression
… induced by TGF-beta and ECM rigidity during metastatic progression. Through global profiling analyses, we identified microRNAs whose expression was induced by TGF-beta and associated with metastatic potential. In doing so, we identified miR-181a as a TGF-beta-regulated “metastamir” that …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… but not total talin1 expression, correlated with metastatic potential of cultured prostate cancer cells. To directly test whether talin1 phosphorylation activates β1 integrins, I generated talin1 S425 mutants. Expressing a non-phosphorylatable mutant, talin1<sup>S425A</sup> in talin1-silenced …
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Single-Cell Lineage Tracing Of Cancer Metastasis
… Applying macsGESTALT to a mouse model of metastatic pancreatic cancer, we recover ~380,000 CRISPR target sites and reconstruct dissemination of ~28,000 single cells across multiple metastatic sites. We find cells occupy a continuum of epithelial-to-mesenchymal transition (EMT) states. …
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A NOVEL DROPLET-BASED PLATFORM FOR TUMOR SINGLE-CELL ENCAPSULATION AND METASTATIC MULTICELLULAR CLUSTER MODELLING
… tumour cell clusters exhibiting higher metastatic potential than single cells. This thesis introduces a microfluidic-based platform for the controlled generation and culturing of single cells and multicellular CTC cluster models within physiologically relevant, biomechanically …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… pediatric brain tumor known for its aggressive metastatic potential. Despite the well-documented migration of MB cells to other parts of the brain and spinal column, MB chemotaxis is poorly understood. Herein, we examined the in vitro migratory and cellular responses of MB-derived cells to …
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Force regulation in contractile cells by chemical and mechanical signaling
… by epithelial cells has been shown to increase metastatic potential in tumors. The need to understand how these signals affect force generation could provide new insights in identifying targets for treatment. We use computational models to help us gain mech- anistic insight into how cells …
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CRISPR/Cas9-mediated ATG7 knockout results in enhanced osteosarcoma chemosensitivity
… long-term survival rates for OS patients facing metastatic or recurrent disease remains unchanged. One of the main reasons for this is resistance to anti-cancer therapies, which has become a major obstacle to improving OS treatment. Chemoresistance in OS appears to be mediated by a myriad of …
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Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
… levels in melanoma cells with high versus low metastatic abilities. Using SILAC (stable isotope labeling with amino acids in culture) coupled with nano-spray tandem mass spectrometry, this work led to the discovery of C̲ub Ḏomain C̲ontaining Protein 1 (CDCP1) as one of those differentially …
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