Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"metastatic colonization"”.
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Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
<p>Metastatic disease is the major cause of death in all solid tumor cancers. Current therapeutic strategies fail to target metastasis as the genes and mechanisms that regulate this process remain poorly understood. Metastatic colonization is the final step of the metastatic cascade whereby cancer …
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Identification of TMEM2 as a SOX4 Transcriptional Target Involved in Breast Cancer Metastasis
… SOX4, is sufficient to promote breast cancer metastatic colonization and its expression in high-risk primary breast tumors associates with metastatic relapse likelihood. Interestingly, independent studies wherein SOX4 or TMEM2 have been genetically inactivated have resulted in similar cardiac …
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Network Modeling Stochastic and Deterministic Approaches
… of macrometastases in the developed model for metastatic colonization in tumor growth. The methods of network theory proves particularly suitable to reproduce the local interactions among tumor cells that lead to the emergent global behavior of the metastasis as a community. This model for …
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… This proliferative advantage supports metastatic colonization of melanoma cells and confers insensitivity to inhibitors of the mitogen-activated protein kinase (MAPK) pathway, a frequent target for melanoma treatment. Rac1P29S bypasses the MAPK axis through a mechanism that necessitates …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… as tumor promoter to enhance tumor cells metastatic dissemination and expands metastatic colonies. Currently, the mechanism of how TGF-β switches its role from tumor suppressor to promoter still remains elusive. Here we identify that overexpression of 14-3-3ζ inhibits TGF-β’s cell …
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Germline Genetic Modulator of Cancer Metastasis
… outcome. Identifying patients at risk for metastatic relapse facilitates clinical decision and the use of appropriate adjuvant therapy, thus having a profound impact on patient survival. A central dogma in cancer is that during tumorigenesis, cancer cells acquire somatic mutations that …
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Investigating the Role of Muscleblind-Like 1 in the Suppression of Breast Cancer Progression
<p>Breast cancer is a prevalent disease. Metastatic disease accounts for the majority of deaths from breast cancer, as patients with distant metastatic disease have a much worse prognosis than those with localized disease. In order to better understand why some breast cancers metastasize and others …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… metastasis through inhibition of cell-autonomous metastatic phenotypes of cell migration and invasion, the role of miR-126 in metastasis remained unknown. Here, endogenous miR-126 is shown to regulate the non-cell autonomous phenotype of endothelial recruitment to metastatic breast cancer cells. …
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Roles of the MicroRNA miR-31 in tumor metastasis and an experimental system for the unbiased discovery of genes relevant for breast cancer metastasis
… associated with the propensity to develop metastatic disease in human breast cancer patients. Additionally, various functional analysis revealed that miR-31 expression was both necessary and sufficient to impede breast cancer metastasis. These effects did not involve confounding influences …
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The Role of Neuronal Pentraxin 1 in Promoting Pancreatic Cancer Progression
… stage disease at the time of diagnosis and metastatic pancreatic cancer has a median survival of eight to eleven months under current standard of care. In the United States, pancreatic cancer is the fourth leading cause of cancer death. Efforts in using targeted agents to treat pancreatic …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, arrival at the end organ and finally colonization of the end organ. The liver is the …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… models that support the tumor progression and metastatic spread of human melanoma. Our results show that location of myeloid cells within the tissue, as well as antigen cargo, have a significant impact on cell's transcriptomic profile and potentially function. Thus, our approach developed in …
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Functional miRNA regulation of metastatic genes promotes tumor cell dissemination in non-small cell and small cell lung carcinomas
Tumor progression, from initiation to advanced metastatic disease, requires the orchestration of a diverse group of cell-intrinsic and extrinsic factors. This multifactorial disease is promoted by an accumulation of genetic and epigenetic changes that confer selective advantage to cells and enable …
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A proteomics study to investigate the role of the neural niche in the development of metastatic HER2+ breast cancer
… of molecular factors, that in turn augment the metastatic colonization of cancer cells. A better understanding of this crosstalk is indispensable to apprehending the complexity of the metastasis process, and to facilitating the discovery of biomarkers that predict metastatic potential and …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
<p>Metastatic disease presents diverse therapeutic challenges for cancer patients, clinicians, and scientists. Cancer cells have developed sophisticated mechanisms of evasion to survive the selective pressures provided by the metastatic cascade. Two themes of success encompass modulating their …
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Regulation of Systemic and Cellular Metabolism In Prostate Cancer By Camkk2 and Elucidation of Atgl’S Role In Disease Progression
… cancer progression, exhibited CAMKK2-dependent metastatic colonization of neuroendocrine prostate cancer in the lungs. Tumors in <em>Camkk2-/- </em>mice surprisingly demonstrated a decrease in cell size that is likely due to decreased mTOR signaling. These data, combined with the observation …