Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"metastatic cascade"”.
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Tumor cell deformability in the metastatic cascade
… (SMR), as related to different stages of the metastatic process-particularly, in an epithelial-mesenchymal transition (EMT) and existence in the circulation. We find that a mesenchymal population of murine tumor cells (MMTV-PyMT) that had undergone a spontaneous EMT at the primary tumor site …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… blood vessels is also an important step of the metastatic cascade that enables development of macrometastasis and growth to secondary tumours. Thus, intratumoral blood vessels represent an important target for anticancer drugs. The two classes of antivascular chemotherapeutics are …
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Fluid Shear Stress Effects on Cancer Metastasis
… phenomenon. Fluid shear stress is common to all metastatic events but its effects on circulating tumor cells (CTCs) remains a mystery. It is known that shear stress can act either directly, causing membrane rupture and cell death, or by altering cell phenotype via mechanotransduction pathways, …
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Intracellular and extracellular promoters of metastasis to different organs
… how tumor cells complete the many steps of the metastatic cascade to how they can adapt to survive in multiple, vastly different secondary sites. I have therefore conducted two studies into different aspects of metastasis. First, I investigated the scaffold protein IQGAP1, which promotes primary …
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Studying the Role of Mechanical Properties of Cancer Cells in Tumour Detachment, Migration and Secondary Tumour Formation
… mechanics contribute to different stages of the metastatic cascade. Directed cell migration was mechanically induced through 2D in vitro scratch assays whereas tumour cell detachment and tumour formation processes were modelled in 3D in vitro collagen matrices using cell spheroid invasion assays …
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3D Coiling at the Protrusion Tip: New Perspectives on How Cancer Cells Sense Their Fibrous Surroundings
… by the fibrous TME greatly facilitate the metastatic cascade. Consequently, there has been a tremendous wealth of work devoted towards elucidating different modes of cancer cell migration. However, our knowledge of how cancer cells at the primary tumor site initially sense their fibrous …
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Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis
… research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific therapeutics; however, current in vivo metastasis model systems are not efficient tools for isolating a single molecular event from the network of complex biological pathways. In …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… breast cancer (TNBC) is a highly metastatic breast cancer subtype. The epithelial-to-mesenchymal transition (EMT) of cancer cells is a key feature of the metastatic cascade and is not a binary process but often generates malignant cells with both epithelial (E) and mesenchymal (M) …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
… invasion represents a critical early step in the metastatic cascade, and many proteins have been identified as part of an “invasive signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from this …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… that function specifically to drive steps in the metastatic cascade independent from, or perhaps even to the detriment of, tumor initiation and growth 5. The development and implementation of a discovery framework that integrates next-generation RNA-sequencing with in vivo selection, has …
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Cooperative Invasion Between Tumor Cell Subpopulations
… Tumor cell invasion is an early step in the metastatic cascade which can occur collectively by multiple cells cooperatively invading into the surrounding stroma. Primary patient breast tumors and patient-derived breast cancer cells can collectively invade yet how cells collectively invade is …
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Discovery of Novel Mechanisms Regulating Cancer Extravasation in the Chorioallantoic Membrane Model
… and establish the secondary site in the metastatic cascade. Although extravasation encompasses key events during cancer cell invasion to aid in the development of effective treatments, an in vivo model that rapidly, reproducibly and economically recapitulates cancer cell extravasation is …
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Estrogen in ovarian cancer cell metastasis
… In contrast, its influence in the metastatic cascade of ovarian tumor cells remains obscure. In this study, I have focused on the role of 17β-estradiol (E2) in ovarian tumorigenesis. EMT related genes including E-cadherin, Snail, Slug, and Twist were examined. E2 treatment led to …
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Functional characterization of mobilized tumor cells
… thesis is focused on the circulation step of the metastatic cascade, examining three types of mobilized tumor cells: circulating tumor cells (CTCs), intraoperatively shed tumor cells, and malignant pleural effusions (MPE). We investigated the functional behavior of mobilized tumor cells in order …
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Adhesion-GPCRs in cancer progression and metastasis
… murine mammary carcinoma cell lines with varying metastatic abilities as well as tumor samples of different grades, I have identified several candidate genes with possible roles in breast cancer progression and metastasis. Based on these analyses and cross-referencing with the published gene …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, arrival at the end organ and finally colonization of the end organ. The liver is the …
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Cellular Plasticity And Heterogeneity: Implications In Tumor Cell Invasion And Metastasis
… in cancer cells that may be important for the metastatic cascade. We subsequently investigated other potential mechanisms of metastasis that may occur as tumors evolve de novo. Specifically, we analyzed paired primary tumors and metastases using a multi-fluorescent lineage-labeled mouse model …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… important, but poorly understood steps of the metastatic cascade namely cancer cell-endothelial cell adhesion and transendothelial migration, using a rocking adhesion assay system in a model of breast cancer metastasis. Three breast cancer epithelial cell lines - MCF 7 and ZR 75 1, derived from …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… of cancer cells and the formation of metastatic disease. Emblematic of the problem is the clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… generally curable, the survival of patients with metastatic breast cancer is very poor. Treatment for metastatic breast cancer is palliative not curative due to the lack of targeted therapies. Metastasis is a complex process that still remains poorly understood, thus a detailed understanding of …
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