Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"metastatic breast cancer"”.
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RNA Deregulation in Metastatic Breast Cancer
<p>Breast cancer is the most commonly diagnosed and second highest cause of cancer-related mortality in women, with the majority of deaths associated with metastatic spread of tumors to distal organs. The metastatic process involves multiple sequential steps including invasion of the surrounding …
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Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy
… a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the …
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Immune responses in primary and metastatic breast cancer
Abstract Breast Cancer is a heterogeneous disease, which affects one in ten women in the UK today. Developments in recent years have led to earlier diagnosis and improved treatments and survival. However, mortality is still high and metastatic disease remains incurable. The role of the immune …
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Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
… kinase that is commonly over-expressed in cancers such as those of the prostate, colon, lung, and breast. For breast cancers, EphA2 overexpression is most prominent in the ER-negative subtype, and is associated with a higher rate of lung metastasis. Studies conducted to demonstrate the role …
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Impact of metabolic pathways on ER+ metastatic breast cancer therapy response
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Quality of life in patients with metastatic breast cancer : A South African perspective
Please read the abstract in the section 00front of this document
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From Surviving to Metaviving: A New Rhetorical Formation in Metastatic Breast Cancer Patient Discourse
… explores how language has evolved as metastatic breast cancer (MBC) has shifted from an imminent death sentence to a potentially chronic disease. War rhetoric, of which the survivor trope is a part, has been the primary mechanism by which healthcare defines the cancer experience. Using …
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How Spirituality and Fatigue Interact to Affect Quality of Life in Patients with Metastatic Breast Cancer
… with a stressful chronic illness, specifically metastatic breast cancer (MBC). If an individual appraises their MBC as stressful and concludes that they have the coping resources and ability to use them, they may effectively cope with and adapt to the stressor. Spirituality may be an important …
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Understanding liver metabolic effects of estrogens and liver niche-related metabolic changes in metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Prophylactic Cranial Irradiation Reduces The Incidence of Brain Metastasis In A Mouse Model of Metastatic Breast Cancer
… survival in select patients with small cell lung cancer and acute lymphoblastic leukemia. A population of breast cancer patients – stage IV, HER2+ or triple-negative – has emerged as having a high risk of developing brain metastases. Because only 10-20% of breast cancer patients diagnosed with …
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Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
Cancer is one of the leading causes of death in the world. For women in the U.S. and the European countries, breast cancer is the most common type and it continuously threatens the lives of the patients and causes huge economic losses. Chemotherapy and endocrine therapy are the common treatments …
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Nuclear receptor TLX and dietary habits: Identifying new targets for the treatment and prevention of metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Using resonant MEMS pedestal sensors and filtering techniques to determine the growth curve of MDA-MB-231, metastatic breast cancer cells
… to surfaces, and ultimately the nature of cancer cells. A resonant pedestal sensor was used to study single, adherent cells non-invasively. This measurement tool was preferred over other methods because the mass uniformity of its surface is independent of the location of the cell. Images …
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Συστηματική ανασκόπηση: Ο ρόλος των AKT αναστολέων στον μεταστατικό καρκίνο του μαστού / Role of AKT inhibitors in metastatic breast cancer: A systematic review
Σκοπός: Η απορρύθμιση του μονοπατιού σηματοδότησης PI3K/AKT/mTOR αποτελεί συχνό μοριακό γεγονός στον καρκίνο του μαστού και έχει συσχετιστεί με την εξέλιξη της νόσου και την ανάπτυξη θεραπευτικής αντίστασης. Σκοπός της παρούσας συστηματικής ανασκόπησης ήταν η αξιολόγηση της αποτελεσματικότητας και …
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Supplementation of licorice root and epimedium in a control or high fat diet and their effects on a preclinical metastatic breast cancer model
… may play a role in the progression of breast cancer. The majority of botanicals lack established data on safety and efficacy. They also present the likelihood for interactions to occur, such as with the high fat diet that is consumed in many Western countries. Two such botanicals, …
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Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
… goal in therapeutic management of HR+/HER2– metastatic breast cancer (MBC). However, recent reports continue to highlight substantially high chemotherapy utilization in earlier therapy lines. In this study, we explored the impact of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor therapy …
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Perfil de utilização do trastuzumabe no tratamento do câncer de mama
… System (SUS, in Portuguese) in 2013 to treat non-metastatic breast cancer with over expression of HER2. The aim of this study was to evaluate the diffusion and patterns of use of trastuzumab in the treatment of non-metastatic breast cancer in the Brazilian Southeast Region. The production of …
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Cancer Proliferation at the Brain Metastatic Site: A Proteomic Exploration of Inter-Cellular Cross-talk Sustained by Cell-membrane/Secretome Interactions
Brain metastasis of breast cancer is one of the leading causes of mortality in patients suffering from cancer. The unique structure and components of the brain microenvironment, including the brain-blood barrier and the immune-suppressive environment, present significant clinical challenges to …
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Molecular Study of Gβγ Dependent Breast Cancer Cell Migration and Invasion
… oncogenic pathways, thus suppressing prostate cancer formation and growth. In addition, an inhibitor of the Gα/Gβγ protein complex has been shown to have anti-tumor activity. Thus Gβγ subunits may function as potential links between GPCRs and tumor transformation and growth. The aim of the …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… three microRNAs that robustly suppresses breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 suppressed metastasis through inhibition of cell-autonomous metastatic phenotypes of cell migration and invasion, the role of miR-126 in metastasis remained …
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