Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"metastasis-free survival"”.
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A Study On The Function of 14-3-3Sigma In Regulating Cancer Energy Metabolism
… tumor cells with significant advantages for survival, proliferation, growth, metastasis and resistance against anti-cancer therapies. Glycolysis, glutaminolysis and mitochondrial biogenesis are among the most essential cancer metabolic alterations because these pathways provide cancer cells …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
… at two institutions, were reviewed. Overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS) were performed using Kaplan-Meier analysis. Univariate and multivariable logistic regression models were used to identify significant associated factors. …
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Investigating the Role of Muscleblind-Like 1 in the Suppression of Breast Cancer Progression
… as a novel suppressor of breast cancer metastasis. MBNL1 loss-of-function contributes to the pathogenesis of myotonic dystrophy, a human genetic disease, but has no reported role in tumorigenesis or cancer progression. In this study, MBNL1 is identified as a suppressor of breast cancer …
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
Metastasis is the principle cause of the deaths among breast cancer patients. Brain is one of the major sites of metastasis in breast cancer; however, the pathological mechanism is poorly understood. One of critical steps of brain metastasis is the breaching of the BBB and this process is …
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Roles of the ING1 Epigenetic Regulator in Breast Cancer
… role in breast cancer development and metastasis was unknown, we analyzed ING1 levels in patient samples and correlated it to patient outcome. We also studied the effects of altering ING1 levels in metastasis assays in vitro and mouse metastasis model in vivo. ING1 levels were lower in …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral heterogeneity, the tumor initiating cell model (TIC) states that tumors are composed of cells that form the majority of the tumor and are terminally differentiated. This model …
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
<p>Cancer metastasis is the cause of about 90% of cancer patients' deaths. Despite significant improvements in the past three decades in understanding the molecular bases of oncogenic transformation of cancer cells, little is known about the molecular mechanisms underlying tumour cells' alteration …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
Metastasis suppressors regulate multiple steps during the process of dissemination of tumor cells from primary sites to distant organs, while they do not affect the growth of the primary tumor. Previously, we identified NDRG1 (N-myc downstream regulated gene 1) as a tumor metastasis suppressor gene …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor …
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Risk stratification in the management of localised prostate cancer treated with radical radiotherapy
… proven prognostic for biochemical failure-free and metastasis-free survival in surgical patients was, for the first time, shown to be prognostic for the same outcomes in men treated with radical radiotherapy. Neither pre-radiotherapy PSA nadir nor neutrophil-lymphocyte ratio, both clinical …