Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 959 for “"metastasis"”.
-
Biomechanical regulation of cancer metastasis
Metastasis is the ultimate cause of most cancer-related deaths. As such, it is critical to understand the processes that control the spread of cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the …
-
MUC13 Enhances Colorectal Cancer Metastasis
… down to 14% when the disease has metastasized. Metastasis is the cause of 90% of all cancer related deaths, which necessitates the need to understand the mechanisms regulating different progression steps. Metastasis is a complex and multistep process, whereby cancer cells leave the primary tumor …
-
Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
… the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I utilized two distinct methods of E-cadherin inhibition that distinguish between E-cadherin's cell-cell adhesion and intracellular …
-
Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
… of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute in various ways to tumor initiation and progression, and plasma membrane proteins are …
-
Estrogen in ovarian cancer cell metastasis
… process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of migration and invasion by temporal phenotypical and genotypical changes termed epithelial-mesenchymal transition (EMT). Considerable evidence implicates a mitogenic action of estrogen in early ovarian …
-
Germline Genetic Modulator of Cancer Metastasis
<p>Metastasis formation is the most critical determinant of cancer survival outcome. Identifying patients at risk for metastatic relapse facilitates clinical decision and the use of appropriate adjuvant therapy, thus having a profound impact on patient survival. A central dogma in cancer is that …
-
Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …
-
Cancer metastasis and elasticity of microenvironment
… by metastases, not by the parent tumor. During metastasis, malignant cells detach from the parent tumor, and spread through circulatory system to invade new tissues. Due to the intrinsic difficulties of predicting and monitoring in vivo metastasis, the physical-chemical mechanisms and parameters …
-
Intravital imaging of metastasis in zebrafish
Metastasis is the cause of the overwhelming majority of cancer deaths. However, it remains a poorly understood process. The events at the metastatic site are especially poorly comprehended. These events are dynamic and so require intravital imaging to investigate. However, the intravital imaging of …
-
Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
<p>Metastasis is a highly complex, multi stage process that is clinically daunting, causing the majority of deaths from solid malignancies. A previous study identified three microRNAs that robustly suppresses breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 …
-
Single-Cell Lineage Tracing Of Cancer Metastasis
The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient single-cell capture of both transcriptional and …
-
Wnt-5a signaling in breast cancer metastasis
… protein is associated with a higher frequency of metastasis. The findings presented in this thesis show that Wnt-5a inhibits the metastatic behaviour of breast cancer cells by blocking Ca2+-induced NFAT activation. This inhibition is mediated through activation of Yes, Cdc42 and CK1?. Furthermore, …
-
Role of ATRX in colorectal cancer metastasis
… was to determine the effect of ATRX loss on metastasis using mouse models. In addition to this, I wanted to explore the mechanism by which ATRX loss facilitates the observed phenotype, specifically focusing on its role as a chromatin remodelling protein. In this thesis, ATRX loss is …
-
Adhesion-GPCRs in cancer progression and metastasis
… possible roles in breast cancer progression and metastasis. Based on these analyses and cross-referencing with the published gene expression data on human breast cancer cell lines and patient samples, I chose two candidate genes, CELSR2 and GPR126, for more detailed investigation. To elucidate …
-
Fluid Shear Stress Effects on Cancer Metastasis
Metastasis is responsible for at least 66% of cancer-related deaths, yet it remains a poorly understood phenomenon. Fluid shear stress is common to all metastatic events but its effects on circulating tumor cells (CTCs) remains a mystery. It is known that shear stress can act either directly, …
-
Breast cancer cells cooperate during invasion and metastasis
Metastasis continues to be the leading cause of breast cancer-related deaths. Metastasis is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of …
-
UNDERSTANDING METASTASIS MIXED - TREATMENT RESPONSES THROUGH GENOMIC ANALYSES.
Early and metastatic breast cancers can exhibit heterogeneity, among patients and even within the same individual. Response to therapy in metastatic breast cancer patients with multiple metastases can also be heterogeneous, with different degrees of responsiveness to the same drug(s) across …
-
Tissue Oxygen Imaging for Non-invasive Metastasis Detection
As metastasis is responsible for a majority of cancer deaths, early and accurate metastasis detection is vital for developing better treatment plans and improving survival rates. Sentinel lymph node biopsy is the gold standard for metastasis detection for many cancers. It involves injecting a blue …
-
ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor …
Page 1 of 48