Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"metastable oligomers"”.
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Probing the conformational dynamics of amyloid oligomers in biologically relevant microenvironments
… disease (AD). It is generally accepted that metastable oligomers are the principal cytotoxic species, which permeabilize plasma membranes and induce Ca2+ dysregulation. In the 25 years since the introduction of the oligomer hypothesis, the phenomenon remains poorly understood. While some …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
… lag times, small stable soluble peptide oligomers start to form. These oligomers, which were characterised using a number of different biophysical techniques, may be off-pathway species of amyloid fibril formation or products of partial peptide degradation. The aggregation kinetics were …