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Showing 1 to 20 of 28 for “"metalloproteases"”.
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Chemical biology of matrix metalloproteases
Matrix Metalloproteases (MMP) inhibition is currently brought to the focus of medicinal chemistry research due to their essential roles in many human diseases. To elucidate the functions of each individual MMP, it is imperative to synthesise small molecule/probes which can selectively target a …
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Elucidating the Molecular Function of Reprolysin Metalloproteases in Tick-Host-Pathogen Interaction
… including a variety of proteases. Reprolysin Metalloproteases, in the Zn<sup>2+</sup> dependent family, is secreted as a proenzyme and is shown to have proteolytic activity, degrading fibrinogen and gelatinase activity, as well as disturbing homeostasis<sup>1</sup><sup>2</sup>. Previous work …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. By 21 days after birth virtually all rod …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… tuberculosis (M. tb). Upregulation of matrix metalloproteases (MMPs) has been documented in patients with tuberculosis (TB), while their tissue inhibitor (TIMPs) levels remained the same. Animals which can develop cavities have well-conserved MMP-1 orthologs suggesting a pivotal role of MMP-1 …
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
Asthma is a chronic respiratory disease that results in a constriction of the airways. While there is no known cause of the disease, one possible theory of the molecular cause of asthma is that the tight junctions of the airway epithelium are disrupted as a result of cytokine activity that up …
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Erwinia carotovora extracellular proteases: characterization and role in soft rot
… inhibited by phenanthroline, which inhibits Zn-metalloproteases, but not by Ecc intracellular proteins. Analysis of deletion mutants indicated a 1.2 kb region necessary for Prt1 production. Sequencing of the pSK1 insert revealed a 1,041 bp open reading frame (ORF1) corresponding to the prtl …
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The exo-proteomic framework for nitrogen acquisition from proteinaceous organic matter in the model marine heterotroph Ruegeria pomeroyi DSS-3
… extracellular environment. We found serine-, and metalloproteases to be important for periplasmic proteolysis, and propose an essential role for metalloproteases in the acquisition of proteinaceous nitrogen. Increased amino acid and oligopeptide uptake capabilities as well as higher abundance of …
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Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group
… and P. falciparum A M1 (PfA-M1) are both zinc metalloproteases implicated in hypertension and malaria, respectively. Hypertension affects approximately 26 % of the world’s population while each year over 300 million cases of malaria occur worldwide resulting in between 1.5 and 2.7 million …
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Modifikace peptidového substrátu pro pappalysiny zavedením pseudopeptidu do štěpeného místa
… (IGFBPs), which are substrates of pappalysin metalloproteases (PAPPA-A, PAPP-A2). These enzymes regulate the bioavailability of insulin-like growth factors (IGF) by cleaving the IGFBPs. The peptide modification consists of the preparation of a pseudodipeptide block containing a phosphinate …
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Multiscale Mathematical Modelling of Cancer Invasion
… matrix degrading enzymes include the matrix metalloproteases (MMP) and the urokinase plasminogen activator (uPA).<br/><br/>This thesis has investigated the complex process of cancer growth and spread that occur across several different spatial scales, in order to gain a better understanding …
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Developing a Caenorhabditis elegans Model for Marfan Syndrome
… the L4 molt and that fibrillin-1, TGF-β, and metalloproteases may act in-concert to modulate TGFβ availability and connective tissue integrity in C. elegans. In addition, we found that two independent mutations of mua-3 show temperature-sensitive phenotypes. Based on this result, we propose …
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Elucidation of the Proteases Responsible for and the Form of Soluble, Monomeric EphrinA1 Released From Cancer Cells
… form. We demonstrate here that multiple matrix metalloproteases (MMPs) are able to cleave ephrinA1, most notably MMP-1, -2, -9, and -13. The proteolytic cleavage that releases ephrinA1 occurs at three positions within the C-terminus, ending in amino acids valine-175, histidine-177, and …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… that SPARC increases expression of the matrix metalloproteases (MMPs) MT1-MMP and MMP-2. We also demonstrate that SPARC increases MMP-2 activation and the secretion and processing of galectin-3, a known target of MMPs. To investigate the roles of specific domains, we used a SPARC-GFP fusion …
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ROLES OF 15-LIPOXYGENASE-2 (ALOX15B) IN SUPPRESSION OF TUMOR FORMATION, METASTASIS, AND SENSITIVITY TO CHEMOTHERAPY
… expression of the mesenchymal markers and matrix metalloproteases. In addition, we proved the ability of 15-LOX-2 to inhibit the tumor growth in vivo and increase the chemotherapy sensitivity in vitro. To investigate the biological role of 15-LOX-2 in vivo, we used mice with a deletion in the …
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EFFECT OF HISTIDINE TAG ON THE ENZYMATIC ACTIVITY OF PSEUDOLYSIN AND ITS INTERACTION WITH THE STREPTOMYCES METALLOPROTEASE INHIBITOR (SMPI) PROTEIN
… PLN belongs to the family of zinc-dependent metalloproteases. It is naturally inhibited by a smaller protein called streptomyces metalloprotease inhibitor (SMPI), secreted by <em>Streptomyces nigrescens</em>. Previous and current studies demonstrate that the interaction between PLN and SMPI …
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Investigations into the digestive system proteases of Argiope aurantia (Araneae: Araneidae), hemolytic agents of spider venoms, and the role of both in necrotic arachnidism
… and meprins, which are in the astacin family of metalloproteases.</p>
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The Gelatinases and Autoimmune Disease
<p>Matrix metalloproteases (MMPs) are critical to an array of homeostatic processes but have also been implicated in many pathological states. The roles they play in innate immunity, regulation of physical barriers such as the blood brain barrier, and the healing process are the same ones that …
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Identification and characterisation of proteases in Mycobacterium tuberculosis
… proteases, notably subtilisins, and possibly metalloproteases. Purification attempts were unsuccessful. A family of five genes that encode putative, secreted, serine proteases has recently been described in M. tuberculosis. These proteases share 36-47% sequence identity and are all encoded …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… of inflammatory factors such as matrix metalloproteases (MMP's). Caveolae has been shown to play a role in a number of different cardiovascular diseases through different mechanisms including regulation of oxidative stress, inflammation and degradation of extracellular matrix components …
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Regulated intramembrane proteolysis in the control of the Bacillus subtilis anti-sigma factor RsiW.
… to a superfamily of potential membrane embedded metalloproteases (MEM) with so far unknown function in bacteria. Further characterization of PrsW in a reconstituted E. coli system showed that PrsW cleaves RsiW in a site-specific manner to form a protein truncated for 40 C-terminal …
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