Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"metallohydrolase"”.
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Structural Studies of Two Related Metallohydrolases: Human Histone Deacetylase 8 and Malarial Arginase
… HDAC8, originally thought to be a Zn2+-metallohydrolase, exhibits increased activity with Co2+ and Fe2+ based on kcat/KM (Gantt, S. L., Gattis, S. G. & Fierke, C. A. (2006). Biochemistry 45, 6170-6178). Here, we report the first X-ray crystal structures of metallosubstituted HDAC8: …
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Investigations into the molecular basis of enzyme-catalyzed reactions in natural product biosynthesis
… This enzyme, termed PsfC, possesses a metallohydrolase fold, but not share the canonical trinuclear metal center-binding motif associated with the class of enzymes. Structural characterization of PsfC reveals that it binds two equivalents of iron, which is necessary for the enzyme to …
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Enzymatic Characterization of N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)
Mycobacterium species, which contain the causative agent for human tuberculosis (TB), produce inositol derivatives including mycothiol (MSH). MSH is a unique and dominant cytosolic thiol that protects mycobacterial pathogens against the damaging effects of reactive oxygen species and is involved in …