Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"metallodrug"”.
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Investigating domain-selective angiotensin converting enzyme inhibition and oxidative inactivation
… by the Cu-Gly-GlyHis-lisinopril (CuGGHLis) metallodrug. Although both domains displayed nanomolar affinity for metallodrug binding (N-domain Ki = 44.94±1.84nM and C-domain Ki = 15.57±1.30nM), rapid and complete CuGGHLis-mediated inactivation occurred exclusively in the N-domain upon …
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The development of group VIII trinuclear transition metal complexes as chemotherapeutic and photodynamic therapy agents
… which may lead to the identification of new metallodrug candidates. The purpose of this study was to investigate the synthesis and characterization of a series of trinuclear transition metal- containing complexes based on the benzimidazole scaffold, and the investigation of the applicability …
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Design and modification of rhodium and iridium N-heterocyclic carbene complexes for asymmetric transfer hydrogenation and antimicrobial activity
The two projects described in this dissertation demonstrate the wide utility of noble metal N-heterocyclic carbene (NHC) complexes. The first project details the design of iridium NHC amino acid complexes for asymmetric transfer hydrogenation (ATH) of prochiral ketones. Iridium(I) bis-NHC complexes …