Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"metallo-β-lactamase"”.
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… class of antibiotic-degrading enzymes, the metallo-β-lactamases (MBLs). MBLs are a family of Zn(II)-dependent enzymes that inactivate most of the commonly used β-lactam antibiotics. In Chapter 1 a detailed review of the properties of these enzymes is presented. Novel MBLs are continuously …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… in microbes are a class of enzymes known as β-lactamases. These enzymes are effective in breaking down the most commonly prescribed antibiotics at present. This work investigates two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas …
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Discovery and optimization of inhibitors and probes that target New Delhi metallo-[beta]-lactamase
… of β-lactam hydrolyzing enzymes, known as β-lactamases, threatens their clinical efficacy. β-lactamases typically have a conserved serine in their active site that serves as a nucleophile in hydrolysis of the β-lactam substrate. Codrugs in the form of covalent inhibitors that target this …
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A Genomic And Functional Analysis On The Impact Of Commercial Pesticides On Chlorpyrifos Degradation By Three Bacterial Consortia
… strains revealed a series of OPHC2 like Metallo-β-lactamase (MBL) enzymes. GCMS analysis of bacterial samples contaminated with chlorpyrifos supported microbial biodegradation activity and showed three chlorpyrifos metabolites, including 3,5,6- trichloro-2-pyridinol (TCP), fumaric acid, …
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Studies of the nature of Burkholderia cepacia in cystic fibrosis
… by isolates of B. cepacia was investigated. A metallo-β-lactamase from a clinical strain of B. cepacia was isolated and partially purified of using Cibacron blue F3GA-coupled agarose. The resulting preparation showed a single band of β-lactamase activity (pI 8.45) after analytical isoelectric …
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Toward the structure and function of carbon-phosphorus lyase enzymes
… structure displayed similarity to zinc-dependent metallo-β-lactamase family proteins. However, phnP displays unique structural features with two metal binding sites per monomer: the active site containing potentially two manganese ions, and a ‘structural’ site coordinating one zinc ion. Potential …
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Innovation in antimicrobial resistance: development of new antimicrobials and coadjutants to successfully treat bacterial infections [Innovazione nella resistenza antimicrobica: sviluppo di nuovi antimicrobici e coadiuvanti per trattare in modo efficace le infezioni batteriche]
… i siti attivi dipendenti dallo zinco delle metallo-β-lattamasi (MBL). A tale scopo, sono stati sintetizzati dipeptidi e derivati piridinici, che insieme a diversi farmaci e biochelanti, sono stati studiati come potenziali coadiuvanti per ripristinare l'efficacia degli antibiotici β-lattamici …