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Showing 1 to 12 of 12 for “"metal chelators"”.
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… of P. falciparum. A series of novel iron chelators were designed and synthesized based on thiosemicarbazone and/or ferrocenyl moieties. The novel compounds were characterized by NMR, infrared (IR) and mass spectroscopy as well as microanalysis and subjected to biological evaluation. All …
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Exploring Metallic Flavor Perception: Analysis of Human Salivary Proteins and the Use of the Iron-Binding Protein Lactoferrin in Reducing Metallic Off-Flavors
Metallic flavors are of concern for many industries including food, health, and water. Metallic off-flavor, induced by ferrous sulfate solution (10mg/L), and its remediation using pre- and post-rinse treatments of water (control) or metal chelators, were studied. Metal chelators included …
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Characterization and Molecular Analysis of Fragilysin: The Bacteroides fragilis Toxin
… characteristic of metalloproteinases. Sequence analysis showed close identity with metalloproteinases within the zinc-binding and Met-turn regions. Purified fragilysin contained 1 gram atom of zinc per molecule, and it hydrolyzed a number of proteins, including …
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Food Safe Alternatives to Methyl Bromide in Country Ham Production
… reduced even after treatments with antioxidants, metal chelators, and pH neutralization. In total, garlic juice acted as a short term repellent and showed efficacy in contact models, but application is time sensitive due to variable enzymatic degradation.
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Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
… 3.0, 4.0, and 5.0), then reacted with two strong metal-chelators: aminofunctionalized terpyridine (synthesized from 2,2’:6’,2’’-terpyridine) and Nα-Nα-bis(carboxymethyl)-L-lysine (Lys-NTA). First of all, Cu(II) metal ion binding capacities were measured on the surfaces. Second, two terminal group …
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Synthesis of anticancer agents: 15-deoxy-15-fluoro-Δ12-prostaglandin J3 and gukulenin monomeric units
… for their antitumor effects; and, as potent metal chelators, these aromatic structural motifs also carry great potential in material science and ligand development. However, research into tropolone-containing compounds has been hampered by their capricious chemical behavior and the …
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Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease
… stress to protein misfolding, misregulated metal ions appear as a common thread in disease pathology. </p><p>Chelation therapy has shown some effectiveness in clinical trials, but to date, there are no FDA-approved metal chelators for the treatment of AD. One of the biggest problems with …
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Sorghum phenolic extracts : their storage stability and antioxidant activity in sunflower oil
… to act as both lipid radical scavengers and metal chelators. The CPE however imparted colour to the sunflower oil, which could limit its application as a natural antioxidant in edible oils.
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Caldolase: an alkaline serine protease from Thermus strain TOK₃
… carbamyl chloride), partially inhibited by heavy metal (CUCl₂), but not inhibited by metal chelators (EDTA, EGTA, 0-phenanthroline, and NEPIS), Cysteine inhibitors (PCMB, iodo-acetamide, and N-ethylmaleimide) or trypsin inhibitors. These results indicate that Caldolase is an alkaline serine …
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Evaluation and Development of Metal-Binding Agents that Alter Copper Bioavailability
<p>Transition metal ions are required nutrients for many organisms but also potent toxins if misappropriated. Iron (Fe) plays a central role in the transport of oxygen, and other transition metals, such as copper (Cu) or zinc (Zn), are found in enzymes. It is critical for the human body to maintain …
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Design, synthesis and characterization of new iron and aluminium chelating agents
Chelation therapy is widely used for metal-unbalance related diseases, namely those due to disorders on metal metabolism, such as beta-thalassemia, hemochromatosis (Fe), and neurodegenerative diseases (Cu, Fe, Zn and Al). The study of metal chelators for clinical applications, either as chelating …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… against a wide range of cancers with its metal binding capability through its unique dithiol structure. Hence our group is interested in identifying clinically used dithiol compounds which are structurally similar to DS and has metal binding ability to repurpose them as potential …