Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"metabotropic glutamate receptor 5"”.
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
Metabotropic glutamate receptor 5: mGlu5) has been suggested to play a role in the development and maintenance of chronic pain. mGlu5 is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
… that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor 5 (mGluR5) act in functional opposition to regulate local translation of synaptic mRNAs. Fragile X is the most common form of inherited intellectual disability and autism, and is expressed by a loss of FMRP. Previous …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs …
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Targeting troubled translation : investigating novel therapeutic targets in mouse models of fragile X and 16p1 1.2 deletion syndrome
… local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu₅), yet the mechanism by which mGlu₅ couples to the intracellular signaling pathways that regulate synaptic mRNA translation is poorly understood. In this dissertation, we show that manipulation of two novel …
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An Examination of the Mechanisms of Neocortical Network Excitability in a Mouse Model of Fragile X Syndrome
… levels. Pharmacological or genetic reduction of metabotropic glutamate receptor 5 (mGluR5) signaling reduces UP state duration in the Fmr1 KO to normal levels, suggesting a potential therapy for Fragile X patients. These data characterize the novel phenotype of hyperexcitable cortical circuitry …
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Contributions of metabotropic glutamate receptors to the pathophysiology of autism
… altered synaptic protein synthesis downstream of metabotropic glutamate receptor 5 (mGluR5) is a shared disruption in these disorders, and therefore may ultimately contribute to the pathophysiology of ASD in general. First, we show that multiple aspects of mGluR-mediated protein synthesis are …
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The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… the UPEC infection model to identify that metabotropic glutamate receptor 5: mGluR5) is necessary to experience inflammatory-mediated pain responses. We also correlated molecular markers and pain profiles to identify potential biomarkers for diagnosis or treatment of BPS/IC.</p><p>Although …