Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 226 for “"metabolomic"”.
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Metabolomic Signature of Hypertension
Metabolomics is a comprehensive study of small molecular end products of metabolism (metabolites) in living organisms. These metabolites are directly modified by the metabolic processes that are governed by organism’s genome, environment and diet. With advancement in technology, a large number of …
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Metabolomic Approaches in Parasitology
Metabolic pathways and networks are crucial for maintaining cellular functions and sustaining life. Understanding these pathways in parasites may reveal novel targets for therapeutic application if they are sufficiently different from mammalian systems. My work investigated two such pathways: …
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Metabolomic Biomarkers for Colorectal Cancer
… improve the outcome of these patients. Metabolomic profiling, as a method for describing metabolic state and alterations in the molecular constituents and capable of yielding unique and invaluable information about tumor biology, has been employed. Using a range of spectroscopy and mass …
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Metabolomic characterization of Multiple Sclerosis
… the purpose of this thesis, in which I used the metabolomics approach to investigate three main points: 1) Classification of patients affected by different forms of MS (relapsing remitting, RRMS, and primary progressive, PPMS); 2) Monitoring of the response to the Fingolimod therapy; 3) To study …
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Metabolomic modelling and applications in inflammatory bowel diseases
Background: Metabolomics experiments typically produce high dimensional data and its handling is an extremely important step in data pre-treatment. Metabolomics is an indispensable research tool for the identification and tracking of biomarkers in biological systems. In a typical metabolomics …
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Evaluation of the mechanisms of neurotoxcity using metabolomic strategies
… proliferation assays coupled with LC-MS based metabolomics and transcriptomics techniques. Cells were treated with a range of cobalt concentrations between 0 and 200 μM. The metabolism of mephedrone at 100 μM was first studied in primary rat hepatocytes and then the neurotoxicity of mephedrone …
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Dissection of phloem transport in cucurbitaceae by metabolomic analysis
… mechanisms of Cucurbita maxima, by combining metabolomic analysis with cell biological techniques. This putative symplastic loading species has long been used for experiments on phloem anatomy, phloem biochemistry, phloem transport physiology and phloem signalling. Symplastic loading species …
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Metabolomic investigation of food matrices by 1H NMR spectroscopy
… work shows some applications on the NMR-based metabolomic approach in food science. The investigated food matrices are largely different, from a manufactured product that undergoes only physical treatments (bottarga), to a manufactured product where biochemical transformations take place (Fiore …
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Metabolomic profiling of C4 grass responses to environmental stress
Made available in DSpace on 2020-08-26T23:51:25Z (GMT). No. of bitstreams: 4 WEDOW-DISSERTATION-2020.pdf: 2254191 bytes, checksum: 70fd380d7e3af29dde4932af185c7e5f (MD5) Supplemental Files.zip: 267027 bytes, checksum: e8fd73338d6bf5cbd1d0c0b0a9f857f6 (MD5) LICENSE.txt: 4210 bytes, checksum: …
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Metabolomic profiles of Oryza sativa and influence of genetic diversity
… in health properties of dietary components. Metabolomics is a useful tool to assess the influence of genetics on total metabolite variation in the cooked grain. Cooked rice metabolite profiles for 10 diverse varieties were determined using ultra performance liquid chromatography coupled to …
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Metabolomic profiling to investigate effect of curcumin in lung cancer
… The objective of this study was to use the metabolomic approach to investigate early potential biomarkers for lung cancer. Golden Syrian hamsters were randomized into two groups (treatment and control). Lung cancer was induced in treatment group by a chemical carcinogen, …
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Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
… including cancer. Over the last few years, metabolomics has become an increasingly critical part in many fields of research. Therefore, metabolomic and lipidomic analysis was performed to investigate the effect of different sphingosine kinase inhibitors in prostate cancer cells in order to …
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Metabolomic comparison of selected Helichrysum species to predict their antiviral properties
… responsible for anti-HSV activity using a metabolomics approach. The cytotoxicity of 12 Helichrysum species was investigated and ranged from <3.125 μg/ml to 277.8 μg/ml on the vero cell line. The 12 Helichrysum species also showed various levels of antiviral activity against HSV, with both …
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… The second body of work in this thesis uses metabolomics to assess endophenotypes and disease biomarkers in a population of people with severe IR of known aetiology, mediated by either primary insulin signalling defects or lipodystrophy. Because prognosis and management of these disorders …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2 William T. E. Briggs The cyclooxygenase (COX)-2 inhibitors, or “coxibs,” are excellent anti-inflammatory agents, but their reputation has been tarnished by the adverse cardiovascular (CV) events, including …
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Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches
… be within the MEP pathway. We used proteomic and metabolomic approaches to identify the molecular target of MMV008138 to aid future medicinal chemistry to improve the efficacy of this inhibitor.
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… a total of 182 individual tumor fragments for metabolomics. A tandem mass spectrometry (MS/MS)-based analytical platform was used to characterize 133 metabolites extracted from each tumor specimen. We then used a suite of statistical tools to identify metabolites differentiating H-met from …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… was explained by functional transcriptomic and metabolomic changes in the mice with obesity and diabetes, namely via activation of the AKT/mTOR pathway. Metformin treatment decreased the obesity-induced and diabetes-induced AKT/mTOR pathway activation and tumor growth. Adipokine profile array …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of small molecule metabolites, involving the measurement of large numbers of metabolites in biological samples. The aim of the research was to study the urinary metabolite profile of IL10-/- mice by gas …
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