Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 118 for “"metabolome"”.
-
Signal-metabolome interactions in plants
… analysis focussed on conditionality of signal-metabolome interactions.
-
Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… to profile the aromatic amino acid-derived metabolome of the gut microbiota. By feeding individual bacterial species with each aromatic amino acids, I discovered that these aromatic amino acids generate a diverse metabolome, much of which is absent from the current metabolite database. Among …
-
The functional role of root-associated microbiome and metabolome of myrothamnus flabellifolia
… activity. Exploring the rhizosphere soil metabolome provided insights into the metabolic changes during drought stress in M. flabellifolia. Dehydrated rhizosphere soil exhibited increased levels of sugars (e.g., trehalose), organic acids (malic acid), and phytohormones (indole-3-acetic). …
-
Computational prediction of health status from the human gut microbiome and metabolome
… However, there is growing evidence that the gut metabolome may provide crucial information that cannot be gained from microbial composition alone, as metabolites provide the means by which host cells and microbe cells communicate with each-other. Predictive analyses are especially useful for …
-
Multiplatform metabolome profiling to identify specific signatures and biomarkers in blood samples: untargeted approach
One of the significant challenges in identifying effective therapy in many chronic and neurodegenerative diseases is the need for reliable biomarkers. Thus, new point-of-care diagnostics tools are essential for unambiguously distinguishing diseased patients from healthy ones providing results in …
-
Natural variation of Pinus pinaster metabolome in abiotic stress responses: modeling of omics data
El objetivo principal de esta tesis fue determinar los principales mecanismos de aclimatación al calor y la sequía en P. pinaster y su variación natural empleando un enfoque integrado de biología de sistemas. Para ello, aplicamos diferentes intensidades de estrés, orden de exposición al estrés y …
-
Understanding the impact of different environmental stressors across developmental stages on the hepatic metabolome
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
-
The bacteriome and metabolome of human breast milk and their association with infant growth
… the bacteriome (bacterial communities) and metabolome (complete set of metabolites), and their relationship to infant health and growth have not yet been comprehensively characterized. This is particularly true in low- and middle-income countries. We therefore conducted a cross-sectional …
-
Characterisation of the metabolome of Mycobacterium tuberculosis to identify new pathways and pathway holes
… this study performs a characterisation of the metabolome of Mtb and comparison across the phylogenetic profile to identify notable pathways.
-
Profiling the metabolome using Fourier transform ion cyclotron resonance mass spectrometry, optimised signal processing, noise filtering and constraints methods
The main aim of this research study was to develop methods for metabolic profiling, a process involving the identification of metabolites present in biological samples, by applying Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Three novel methods were developed to improve …
-
Influence of feed efficiency ranking and maternal nutrition on gut microbiome, metabolome, and transcriptome in beef and dairy cattle
… determine differences in hindgut microbiome and metabolome in neonatal dairy heifer calves retrospectively grouped as M-eff or L-eff calves during the preweaning period. Rectal swabs were collected immediately at birth before colostrum feeding (i.e., d 0), and fecal samples were collected at d …
-
Proteome, transcriptome and metabolome plasticity in closely related strains of Escherichia coli - K12 and its diversity during molecular evolution processes
… a cell (transcript or protein abundance). Metabolome profiling has been frequently applied for obtaining quantitative information on metabolites for studies on mutational or environmental effects, but not in an evolutionary context. In our study, we depicted a complete picture of molecular …
-
Optimising the Wider Energy Metabolome of Microbes Using Targeted UHPLC-MS/MS Present in Bio-Electrochemical Systems for Carbon Dioxide Conversion to Platform Chemicals
This thesis addresses a major analytical gap in microbial biotechnology by developing and validating a rapid, sensitive UHPLC-MS/MS platform for simultaneous quantification of the key intracellular energy metabolites that govern redox balance, energy charge, and carbon flux in industrial …
-
Surguvant inflammation and metabolism in colorectal surgery
… cfDNA analysis and profiling of the systemic metabolome. Aims: The aims of this thesis were as follows: 1. Analyse the association between CT-generated body composition parameters (BCPs), inflammation and colon cancer outcomes 2. Novel identification of the perioperative dynamics of cfDNA in …
-
Metabolomic Signature of Hypertension
… measured in various body fluids. The changes in metabolome precede disease phenotypes and thus, provide the niche for use of metabolomics in early detection and prevention of diseases. Several lines of evidence suggest that hypertension is closely associated with metabolic diseases and …
-
Nežindančių motinų pieno maistinių medžiagų koncentracijos pokyčiai po gimdymo ir veiksniai bei procedūros, turintys įtakos jo sudėčiai /
… with Italian researchers, innovative human milk metabolome analysis was conducted; the analysis enabled assessment of pasteurisation impact on human milk metabolome composition and provided knowledge about oligosaccharide composition of human milk of women residing in Lithuania. The findings we …
-
Data integration and visualization for systems biology data
… data were applied to integrate transcriptome, metabolome and proteome data from the V. vinifera project. Phase spectrum combined with k-means clustering was used in integrative analyses of transcriptome and metabolome of the M. truncatula yeast elicitation data and of transcriptome, metabolome …
-
Analysis of fecal biomarkers to impact clinical care and public health
… targets. By analyzing the gut microbiome and metabolome of mice exposed to a high salt diet, we identified Lactobacillus as a potential probiotic to counteract salt-sensitive conditions such as high blood pressure. Next, I present preliminary validation of wipe samples as a patient-friendly …
-
Investigating Epigenetics as a Mechanism to Regulate Bacterial Heterologous Expression
… in cell growth, motility, methylome, and metabolome. We found that epigenetic methylation in B. subtilis regulates the metabolome and serves as rationale for continuing the investigation on whether epigenetic methylation can be used to optimize heterologous gene expression.
Page 1 of 6