Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1822 for “"metabolites"”.
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Metabolites of Aspergillus versicolor
… result of these fractionations a total of eleven metabolites were obtained in pure form. Ten of these were identified as the known compounds, sterigmatocystin, de-0-methylsterigmatocystin, 5-methoxysterigmatocystin, versicolorin A, versicolorin C, aversin, averufin, griseofulvin, …
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Intracellular signalling by arachidonic acid metabolites
In intrauterine tissues, pro-inflammatory cytokines and prostaglandins (PGs) have been identified as key mediators in the maintenance of pregnancy and parturition. The rise in PGD2 detected in the amniotic fluid before labour prompted the research presented in this thesis which describes the …
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Homeostasis of primary and secondary metabolites
The student, Philip Olivares, submitted this Dissertation for approval on 2019-03-11 at 16:15.
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Spectroscopic and synthetic studies of lichen metabolites
Lichen metabolites from various Nephroma and Pseudocyphellaria species have been subjected to a number of spectroscopic and synthetic investigations. Hypoiodite reaction of 15α-acetoxyhopan-17(21)-en-24-ol yielded a complex mixture of products, while similar reaction of 7-oxohopan-22-ol resulted in …
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Profiling of urinary metabolites in human pregnancy
Maternal urinary metabolites (organic acids and steroids) in human pregnancy were profiled by gas-chromatographic methods. Urine specimens were collected from pregnant women at two time intervals in gestation (12½-15½ weeks and 24½-27½ weeks). A group of nonpregnant women was also investigated. The …
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Cranberry metabolites with urinary anti-adhesion activity
… can prevent E. coli adhesion, but the urinary metabolites responsible for this activity are currently not known. High-molecular weight components of cranberry juice, specifically proanthocyanidin oligomers (PACs), are currently believed to be responsible for the ability of cranberry juice to …
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
… metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to the enantiomers of M1 has only been partly studied. This thesis investigates the pharmacokinetics of …
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Nitrogen Metabolites During Exercise in the Horse
In experiment one, eight Quarter Horse mares were intravenously infused prior to exercise with either sodium acetate (control) or ammonium acetate to determine the effect of elevated ammonia (NH$\sb3$) levels on fatigue development and muscle metabolism. The horses were exercised on an 11% grade …
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Synthesis of Mycobacterial Ergothioneine biosynthetic pathway metabolites
Many gram positive bacteria, such as Mycobacterium tuberculosis, lack the redox protective molecule, glutathione and produce mycothiol (MSH) and ergothioneine (ESH) as their principal low molecular mass thiol instead. Ergothioneine has been known for a while as an anti-oxidant; however its role as …
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Carbamazepine and its metabolites in epileptic patients
… in an attempt to assess the role of the metabolites of carbamazepine, viz. 10, 11-epoxy-carbamazepine and 10, 11-dihydro-10,11-dihydroxy-carbamazepine, with regard to their therapeutic efficacy and the occurrence of side effects of the parent drug. It was also designed to seek a possible …
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Secondary metabolites in the Parastagonospora nodorum-wheat pathosystem
… Such is the case for the P. nodorum secondary metabolites (SMs). Bioinformatic analysis of the P. nodorum genome has revealed that it contains around 40 genes responsible for biosynthesising the core structure of different SMs which provides this fungus the capacity to produce a vast array of …
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Secondary metabolites in the Parastagonospora nodorum-wheat pathosystem
… Such is the case for the P. nodorum secondary metabolites (SMs). Bioinformatic analysis of the P. nodorum genome has revealed that it contains around 40 genes responsible for biosynthesising the core structure of different SMs which provides this fungus the capacity to produce a vast array of …
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Detection of brain metabolites in magnetic resonance spectroscopy
… limit detection and separation of several brain metabolites using MR spectroscopic imaging. Existing techniques for improved detection include so-called 2D spectroscopy, where additional encoding steps aid in the separation of compounds with overlapping chemical shift. This is achieved by …
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Secondary Metabolites from Xylaria Endophytes: The isolation and structure elucidation of secondary metabolites from Xylaria endophytes by chemical and spectroscopic methods
… isolation and structure elucidation of secondary metabolites from a number of endophytic Xylaria fungi. Six Xylaria endophytes were surface cultured on an aqueous malt extract-glucose medium. The fungus A311R, from a palm tree in Thailand, produced nonane-1,2,3-tricarboxylic acid, which was …
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Examining coral reef ecosystem dynamics using microorganisms and metabolites
Microorganisms and metabolites are foundational to the success and productivity of biodiverse and economically important coral reef ecosystems and are also tightly connected. Metabolites are small organic compounds produced by reef organisms and are the chemical currencies exchanged by unicellular …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… profiles. However, the mechanism by which the metabolites of the non-bioavailable plant lignan, secoisolariciresinol diglucoside, modulate blood cholesterol levels is not yet known. This study examines a possible mechanism of cholesterol modulation in the liver that involves altered cholesterol …
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
… the abundance and diversity of bacterial metabolites in the intestine is appreciated, the majority of intestinal bacteria and bacterial products have not been characterized in the context of microbiota-mediated pathogen resistance. In this thesis, we describe two projects aimed at …
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