Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"metabolite profiling"”.
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Metabolite Profiling: Correlates and Associations with Incident Cardiovascular Outcomes
… of common CVD related factors (CVRFs) with metabolite profiling and the associations of metabolite profiling with CVD outcomes. I first conducted a comprehensive review of the published literature on the topic to provide background. Next, I conducted cross-sectional analyses assessing the …
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Metabolite profiling of Eragrostis nindensis during desiccation and recovery
… biochemical processes including accumulation of metabolites that shield the plant cells from photo-oxidative damage and reactive oxygen species. A global understanding of the whole plant using a multi-omics approach will provide more insights into how different parts of the plant deal with …
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Development Of Isotags For Nmr Based Metabolite Profiling And Applications
… tool for both qualitative and quantitative metabolite profiling analysis. However, accurate quantitative analysis of biological systems especially using one dimensional NMR has been challenging due to signal overlap. In contrast, the enhanced resolution and sensitivity offered by …
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Exploring horticultural and ecological chemistry through mass spectrometry-based metabolite profiling
… challenges by pairing mass spectrometry-based metabolite profiling (MS-BMP) with heuristic techniques and likelihood assessments for exploring plant chemistry through interdisciplinary, collaborative approaches, and using complementary techniques to test hypotheses generated by exploratory …
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Functional genomics through metabolite profiling and gene expression analysis in Arabidopsis thaliana
… coupled with mass spectrometry-based metabolite profiling. Our results, combined with available biochemical information, provide a better understanding of the physiological role of SABATH methyltransferases, further insights into secondary plant metabolism and deeper knowledge of the …
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Computational Tools to Expand the Coverage of Metabolite Profiling via LC-MS/MS
<p>Metabolite profiling is a recent addition to the suite of high-throughput phenotyping technologies. Unlike measuring gene and protein expression, it is often difficult to anticipate all of the metabolites that are likely to be present in a particular sample. Still, recent efforts to catalog all …
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Metabolite Profiling of Leaves and Vascular Exudates in Soybean Grown Under Free-Air Concentration Enrichment
… and an understanding on inflow and outflow of metabolites in the leaves for a better explanation of source-sink relationships. It is hoped that the results will facilitate the phenotyping of C3 species allowing for the breeding of better adapted crops.
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Quantitative trait loci (QTL) for metabolite accumulation and metabolic regulation : metabolite profiling of interspecific crosses of tomato
… tissues can be efficiently assessed by metabolite profiling techniques, which allow the multivariate detection of metabolites of a given biological sample. Here, a GC/MS metabolite profiling approach has been applied to investigate natural variation of tomatoes with respect to the …
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QTL discovery for Japanese beetle resistance in aphid-resistant germplasm, stacking aphid-resistant genes, and metabolite profiling studies in soybean
… pathway, thus a comprehensive flavonoid profiling study was conducted using High Performance Liquid Chromatography/tandem Mass Spectrometry (HPLC/MS/MS) on three susceptible and three resistant lines. 32 distinct peaks corresponding to glycosides or aglycones of Daidzein, Genistein, …
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Metabolomic approaches to understanding the auxin and ethylene response in Arabidopsis roots
Non-targeted metabolite profiling by liquid chromatography-mass spectrometry (LC-MS) was used to determine the metabolite responses of Arabidopsis roots to auxin or ethylene. Crosstalk between these hormones regulates many important physiological processes in plants, including the initiation of …
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Atvps34, the Arabidopsis Phosphotidylinositol 3-Kinase, Its Functions in ABA and Auxin Signaling Pathways and the Molecular Basis for Salinity Stress Tolerance in Extremophile Thellungiella Halophila
… can survive in sea water. Microarray transcript profiling and intensity analysis, quantitative RT-PCR, and metabolite profiles revealed shared and divergent responses to salt stress in the two species. Sixty percent of regulated genes distinguished Thellungiella from Arabidopsis. Analysis of the …
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In vivo 13C stable isotope tracing of single leaf development in the cold
Measuring the metabolite profile of plants can be a strong phenotyping tool, but the changes of metabolite pool sizes are often difficult to interpret, not least because metabolite pool sizes may stay constant while carbon flows are altered and vice versa. Hence, measuring the carbon allocation of …
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Lysosomal nutrients and the mTORC1 pathway
… of intact mammalian lysosomes suitable for metabolite profiling.
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Identification and analysis of new phloem proteins from Brassicaceae and Cucurbitaceae
… analysis, western blot tests together with metabolite profiling were performed. GC-MS metabolite profiling and enzyme assays were used for measuring metabolites in the phloem of B. napus. Results from the phloem sap measurements showed, as expected, a typical sugar distribution for …
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Hyphenation of analytical techniques to single cell capillary electrophoresis-mass spectrometry
… in nucleic acids, proteins, peptides, metabolites, lipids, and more result in functionally significant differences between cells within the same tissue. Mass spectrometry (MS) has emerged as an effective tool for single cell chemical analysis because of its versatility, sensitivity, and …
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Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches
… as a source of therapeutic targets. Targeted metabolite profiling has aided in the understanding of several biological processes in the parasite besides drug discovery. Therefore, having a robust analytical platform to quantify the purines and pyrimidines is of a great value. For this purpose …
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DEVELOPMENT AND APPLICATION OF NOVEL COMPUTATIONAL INTELLIGENCE TECHNIQUES TO THE MULTIVARIATE ANALYSIS OF METABOLOMICS BIOFLUIDS DATASETS
… of techniques to detect major discriminatory metabolite variables for the purpose of disease diagnosis and progression. Alongside this, is the major demanding requirement to further understand potential metabolic pathways involved in order to improve our understanding of the molecular …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… analytical platform was used to characterize 133 metabolites extracted from each tumor specimen. We then used a suite of statistical tools to identify metabolites differentiating H-met from L-met tumors. We identified durable metabolomic signatures correlating with molecular and biological …
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Rice bran supplementation modulates environmental enteric dysfunction markers and serum metabolites in weaning Nicaraguan infants
… on growth, EED biomarkers, and serum metabolites in healthy, weaning infants from six-to-twelve months old residing in León, Nicaragua. Effects of dietary RB supplementation on growth and EED biomarkers were examined after a six-month feeding period. Five-month-old infants (n=71) were …
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