Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"metabolite formation"”.
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Fate of the herbicide clomazone in soil
Laboratory studies were conducted to gain information about the environmental properties of the soil-applied herbicide clomazone. The effects of soil microbial activity, temperature, and moisture on clomazone fate were determined following ($\sp{14}$C) clomazone application to the surface of a …
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Intestinal absorption and metabolism of bush tea major phenolic compounds exhibiting anti-diabetic activity.
… a model to predict bioavailability and identify metabolite formation, respectively. Specific inhibitors were used to assess efflux characteristics of these compounds. Results: Nine major phenolic compounds of the aqueous extract of A. phylicoides were identified with para-coumaric acid identified …
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A quantitative study of the relationships between morphology, physiology and geldanamycin synthesis in submerged cultures of Streptomyces hygroscopicus var. geldanus
Microbially produced secondary metabolites such as antibiotics have tremendous economic importance. However, most are produced by filamentous organisms which exhibit diverse growth patterns presenting challenges for industrial fermentation. There are many factors affecting secondary metabolite …
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Determination of Absolute Protein Content of Hepatic CYP4F Enzymes in Human Liver Microsomes Using LC/MS/MS Methodology and Comparison with Immunoquantification and Enzyme Activity
… protein contents did not correlate with primary metabolite formation rates for DB289 or DB1230. Chemical inhibition experiments were performed which provided additional evidence for the metabolism for DB289 and DB1230 by enzymes other than CYP4F enzymes. However, a lack of improved correlation …
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Gut Health Benefits of Natural and Alkali-Processed Cocoa (Theobroma cacao) with and without Inulin
… enhance cocoa's health properties, through the formation of new, potentially bioactive high molecular weight compounds. Inulin, a fructose-containing plant polymer, exerts prebiotic effects and has also been investigated in the mitigation of IBD. This study aims to 1) investigate effects of …
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Studies on the metabolic bioactivation of haloperidol (HP) and its tetrahydropyridine dehydration product
… metabolic bioactivation to neurotoxic pyridinium metabolites. In vitro metabolic studies have demonstrated that human monoamine oxidase A and cytochrome P450 3A4 are capable of catalyzing the oxidation of HPTP and/or HP to the toxic HP pyridinium metabolite {4-(4-chlorophenyl)-1-[4- …
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… Menten kinetics (atypical kinetics), multiple metabolite formation and sequential metabolism.To investigate the complexity of cytochrome P450 kinetics, saturation curves and intrinsic clearances (CLint) were simulated for single substrate and multi-substrate models using rate equations and …
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Sorption, degradation and transport of estrogens and estrogen sulphates in agricultural soils
… estrogen sulphates. Estrone was identified as a metabolite of E2 and E1-3S, and these three compounds were observed as metabolites of E2-3S. Single-first order (SFO) and double first-order in parallel (DFOP) kinetics were used to model the degradation and metabolite formation data. The results …
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Treatment of azo dyes in industrial wastewater using microbial fuel cells
… degradation, slow degradation kinetics, toxic metabolite formation, inhibitory costs and generation of secondary waste streams. Therefore, in this study, microbial fuel cells (MFCs) were studied as possible systems that could effectively degrade azo dyes with an additional benefit of …