Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"metabolic side effects"”.
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Genetic Predictors of Metabolic Side Effects of Diuretic Therapy
… Even so, diuretics are associated with adverse metabolic side effects, such as hyperlipidemia, hyperglycemia and hypokalemia which increase the risk of developing type II diabetes. This thesis used three analytical strategies to identify and quantify genetic factors that contribute to the …
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Investigation of the cellular and physiological effects of 5 alpha-tetrahydro reduced glucocorticoids in vitro and in vivo
… exposure to glucocorticoids causes numerous side effects, including obesity, hypertension and type II diabetes. Thus dissociated steroids with anti-inflammatory efficacy and reduced metabolic side effects are an attractive therapeutic goal. A previous study has shown that 5a-tetrahydro …
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Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… Even so, diuretics are associated with adverse metabolic side effects, such as hyperglycemia, which increase the risk of developing type 2 diabetes. Published approaches testing variation in candidate genes (e.g. the renin-angiotensin-aldosteron system (RAAS) and salt–sensitivity genes) have met …
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HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
… two cell types is closely linked to various metabolic diseases. In this dissertation research, we aimed to define the role of activation of ER stress in HIV PI-induced dysregulation of lipid metabolism in adipocytes and hepatocytes and further identifty the potential molecular mechanisms. …
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The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
… however these drugs are not without adverse effects that must be addressed to maximize their therapeutic value. Newer, atypical, antipsychotics are associated with a compilation of serious metabolic side effects including weight gain, insulin resistance, fat deposition, glucose dysregulation …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… (APs) drugs are associated with adverse metabolic side effect. Recent studies have shifted focus onto the central nervous system (CNS) suggesting that APs can induce central insulin resistance and disrupt glucose regulation. Attenuated central insulin action has also been shown to be a …