Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"metabolic reprogramming"”.
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Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer
… new molecular determinants that regulate glucose metabolic pathway would provide promising therapeutic outcomes. Our lab has established the role of MUC13 protein in pancreatic cancer development. Another interesting molecule, Protein Kinase D1 has been reported to play essential role in hypoxic …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… Motif Protein 24 (TRIM24) coupled with metabolic reprogramming and epithelial mesenchymal transition (EMT) in breast cancer. TRIM24 was first established by our laboratory as a previously unknown negative regulator of p53 via its RING domain, as a co-regulator of nuclear receptors and a …
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Metabolic Reprogramming in Response to Mitochondrial Electron Transport Chain Dysfunction
… alterations. The studies herein demonstrate metabolic reprogramming is important in mitochondrial dysfunction; however, the reprogramming is ETC complex and tissue specific.
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… in many cancer types, less is known about the metabolic changes occurring during EMT, particularly in the context of pancreatic cancer. The aim of this thesis was to induce EMT via exposure to two physiologically relevant EMT inducers, Tumour Necrosis Factor (TNF) and Transformation Growth …
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
… mRNA translation and their microenvironmental metabolic support to drive relapse. However, the role of translational reprogramming in the niche was, until now, unclear. This study found that relapsing AML cells increase translation in their bone marrow (BM) niches, where BM mesenchymal stromal …
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Unravelling the roles of the Mck1 kinase in metabolic reprogramming and the stress response
… I intended to find how the Mck1 kinase regulates metabolic reprogramming and the stress response in response to glucose depletion. In the first result chapter (chapter 3), the functional conservation between the budding S. cerevisiae Mck1 and those from the pathogenic fungi was initially …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… limit its efficacy, especially in solid tumors. Metabolic constraints imposed by the tumor microenvironment (TME) greatly influence the success of immune-based therapies. A common metabolic alteration in the TME is lipid accumulation, a feature often associated with defective anti-tumor …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
Tumor initiation and progression depend on the metabolic reprogramming of cancer cells to meet heightened energy and biosynthetic demands. Triple-Negative Breast Cancer (TNBC), characterized by the absence of hormone and HER2 receptors, exhibits high glycolytic and oxidative phosphorylation …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… expression of molecular chaperones, metabolic reprogramming to accumulate storage carbohydrates, activation of antioxidant defence systems, and ultimately the extension of chronological lifespan. These starvation-induced phenotypes were at least partially mediated by three classes of …
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Characterisation of the Effect and Functional Significance of Fcγ Receptor Crosslinking on Metabolic Processes in Macrophages
The metabolic state of an immune cell directly influences its ability to function and differentiate, ultimately affecting immunity, inflammation and tolerance. Different immune cell subsets have differing metabolic requirements. Macrophages, as the frontline, tissue-resident cells of the innate …
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Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
… Furthermore, the influence of LPS induced metabolic reprogramming on mitochondrial ROS (mtROS) production has not been elucidated. Therefore, the aim of this thesis was to determine the mechanism of mitochondrial superoxide production and how this is driven by LPS induced metabolic …
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Resveratrol slows cell growth by targeting the Warburg effect and stimulating mitochondria metabolism
… and cellular respiration. This indicates that a metabolic reprogramming towards oxidative phosphorylation might be essential for RES antiproliferative effects. Indeed, when RES-induced metabolic reprogramming was prevented either by growing cells in galactose or stabilizing hypoxia inducible …
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Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… proliferative capacity, invasiveness and metabolic adaptation typical of tumour cells to support cell growth. One of the major players in this process is Myc, which can promote tumorigenesis by triggering a metabolic reprogramming that allows cells to produce macromolecules, by modulating …
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A genome wide approach to stress response and chronological ageing in yeast
… of TOR/PKA (Rim15, Yak1 and Mck1) coordinate the metabolic reprogramming (to accumulate storage carbohydrates) and the activation of anti-oxidant defence systems (to control ROS levels) to extend chronological lifespan. A ‘genome-wide’ screening of a haploid deletion library indicates that less …
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Unraveling the roles of autophagy in proteome dynamics and energy metabolism in plants under abiotic stress
… Because stress adaptation requires extensive metabolic reprogramming, mechanisms that maintain energetic balance and cellular integrity are critical for plant survival. Autophagy, a conserved intracellular recycling pathway, contributes to the degradation and remobilization of cellular …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… currently incurable. Recent studies suggest that metabolic reprogramming significantly impacts metastatic progression. Understanding the underlying biology of how metabolic reprogramming influences metastasis will shed light on developing novel ways to treat metastasis and is of urgent clinical …
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Untargeted metabolomics and proteomics application of mass spectrometry: from biomarker identification within cells to their spatial localization on tissues
… affected patients. Metabolomics has shown that metabolic reprogramming is another key characteristic of both ageing and cancer, necessary to sustain their survival in adverse conditions. Genomic instability and metabolic reprogramming contribute to the highly heterogeneous and dynamic phenotype …
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Evaluating metabolism in human renal cancer using novel surgical models
… increasing recognition of the pivotal roles of metabolic reprogramming in cancers. Indeed, this evidence has cumulated in the establishment of dysregulated metabolism as a contemporary hallmark of cancer. Metabolomics has been vital to define the metabolic landscape of cancers. This technique …
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