Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"metabolic remodeling"”.
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
Metabolic remodeling is thought to be an important contributor towards the development of various cardiac pathophysiologic conditions. Therefore, studies attempting to delineate undenying mechanisms driving cardiac metabolic remodeling represent an important initiative toward the development of …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… signaling couples microenvironmental cues with metabolic programs to orchestrate the reciprocal development of two fundamentally distinct T cell lineages: αβ and γδ-T cells. Loss of RAPTOR impaired αβ but promoted γδ-T cell development while disrupting metabolic remodeling of oxidative and …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… to increased workload, the heart responds metabolically by increasing its reliance on glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth …
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Pathophysiology of human red blood cell probed by quantitative phase microscopy by YongKeun Park.
… by the P. falciparum parasites; and metabolic remodeling of the membrane driven by Adenosine-5'- triphosphate (ATP). We envision that this investigation could offer a means to link cell membrane fluctuations with the pathological conditions that lead to human disease states by …
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Investigating the role of a JNK-like MAP kinase signaling in regulating dauer developmental arrest in Caenorhabditis elegans
… elegans undergo drastic anatomic and metabolic remodeling to enter a developmental diapause called dauer in response to crowding, diminished food and elevated ambient temperature. The experimental studies of dauer formation have advanced our understanding of how conserved …
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Nampt-Mediated Nad+ Homeostasis in Skeletal Muscle: Implications for Healthy Aging
… a highly dynamic organ capable of structural and metabolic remodeling in response to exercise demands, nutrient supply, and environmental insults. Muscle also plays a central role in the maintenance of whole-body energy balance, capable of both storing and oxidizing carbohydrate and lipid fuels. …
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Effects of Aerobic Capacity Phenotype on Adaptive Responses to Ischemic Stress
… ischemia. Compensatory responses include both remodeling of the vascular network to sustain substrate delivery and adaptive responses within affected tissue to sustain function despite diminished substrate availability. Active aerobic exercise has been shown to improve both vascular and …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… In this study, we aim to characterize the metabolic profiles of cancer persister cells mediated by cancer therapeutics, as epigenetic changes induced by drugs can lead to a transient metabolic rewiring of persister cells that can be associated with the phenotypic switch between normal and …
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An integrated approach to understanding the metabolic rewiring of cancer cells
… recently begun to appreciate the extent of metabolic rewiring required to sustain the uncontrolled growth of tumors. Cancer metabolism is now an active area of research, and efforts are underway to expand the range of oncology diagnostics and therapeutics through targeting metabolism. …
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PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
… between the heart and skeletal muscle driven by metabolic dysregulation; however, its underlying bioenergetics remain unclear. PERM1, a striated muscle-specific regulator of mitochondrial bioenergetics, is highly expressed in the heart and skeletal muscle. We previously demonstrated that PERM1 is …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… This inference has led to increasing interest in metabolic interventions to treat the diseased myocardium, termed metabolic modulation. However, the underlying molecular mechanisms directing cardiac metabolism and the changes occurring during pathogenesis are poorly understood. The chronic …