Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"metabolic rate of oxygen"”.
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Magnetic resonance imaging of the cerebral metabolic rate of oxygen (CMRO₂)
Oxygen consumption is an essential process of the functioning brain. The rate at which the brain consumes oxygen is known as the cerebral metabolic rate of oxygen (CMRO₂). CMRO₂ is intimately related to brain health and function, and will change in settings of disease and functional activation. …
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Multi-contrast Photoacoustic Microscopy
… modality with high spatial resolution, moderate imaging depth, excellent imaging contrast and functional imaging capability. Taking full advantage of this powerful weapon, we have investigated different anatomical, functional, flow dynamic and metabolic parameter measurements using …
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Phase-based regional oxygen metabolism in magnetic resonance imaging at high field
Venous oxygen saturation (Yv) in cerebral veins and the cerebral metabolic rate of oxygen (CMRO₂) are important indicators for brain function and disease. Phase-susceptibility measurements in magnetic resonance imaging (MRI) have been used to quantify Yv in candidate cerebral veins. However, …
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Expanding the role of functional mri in rehabilitation research
… magnetic resonance imaging (fMRI) based on blood oxygenation level dependent (BOLD) contrast has become a universal methodology in functional neuroimaging. However, the BOLD signal consists of a mix of physiological parameters and has relatively poor reproducibility. As fMRI becomes a prominent …
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Measurement of Cerebral Metabolism and Vascular Function with Magnetic Resonance Imaging
… metabolism to function properly. Cerebral metabolic rate of oxygen (CMRO2) is thus an important marker for brain health. Existing techniques for quantification of CMRO2 with positron emission tomography (PET) or magnetic resonance imaging (MRI) involve special equipment and/or exogenous …
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Modelling Blood Flow & Oxygen Transport in the Active Brain
The brain is critically dependent on the supply of oxygen and glucose from the bloodstream. When a brain region is activated, blood flow to that area increases; this phenomenon is termed functional hyperemia, but it remains incompletely understood. In this thesis, a novel mathematical model of …
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MRI based cerebral oxygenation measures in humans : technical development for use across lifespan
MRI based cerebral oxygenation measures could enable brain-centered clinical care and improve understanding of brain energy use throughout human development. We made technical improvements to two MR oxygenation imaging techniques, and explored the concordance between various methods to quantify the …
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Development of integrated imaging techniques for investigating biomarkers in glioblastoma
… human cancer. In this study, we developed integrated imaging techniques using advanced MR and PET to investigate potential biomarkers in glioblastoma (GBM). First, we applied proton magnetic resonance spectroscopy to assess the therapeutic effects of the new antiangiogenic drug (cedianib) on …
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Towards imaging cerebral microvascular blood flow using MRI
Microvasculature consists of arterioles, capillaries and venules, in which the blood flow velocity is slow (≤ 2 cm/s). The hemodynamic signals, blood oxygenation-level dependent response, cerebral blood flow, cerebral blood volume and cerebral metabolic rate of oxygen are the common surrogate …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… </b>The current thesis adopts a whole-body, integrated approach to investigate the impact of acute, chronic and life-long exposure to hypoxia on the functional and structural integrity of the neurovascular unit (NVU). <br/><br/><b>Methods.</b> <i>Experimental Study 1: </i>In a randomised, …