Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"metabolic profiling"”.
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Metabolic Profiling of Genetically Modified Potato Periderm Tissues
… on potato periderm composition, metabolite profiling was conducted on soluble polar and nonv polar extracts from native and wound periderms of wild-type (WT) and FHT-RNAi silenced potato samples using liquid-chromatography mass-spectrometry (LC-MS), gas-chromatography mass-spectrometry …
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Metabolic Profiling of Prions In The Gastro-Intestinal Tract
<p><strong>Metabolic profiling of prions in the gastro-intestinal tract</strong><strong></strong></p> <p><strong>Uffaf Khan, B.S.</strong></p> <p><strong>Thesis Advisor: Claudio Soto, Ph.D.</strong></p> <p><strong>Abstract</strong></p> <p>Prion diseases, also known as transmissible spongiform …
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A Sensor for Metabolic Profiling of Traumatic Brain Injury
… an appropriate medical intervention can be made. Metabolic profiling of extracellular brain fluid can be used to monitor brain health, as it provides data on the efficiency of metabolic processes taking place within the brain. If metabolism is disrupted, causing energy failure in the brain, it can …
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A metabolic profiling approach to human disorders of energy metabolism
… diseases such as diabetes mellitus. The study of metabolic disease depends upon quantitative methods which are traditionally custom-tailored to a given compound. Recent advances in technologies such as mass spectrometry now enable the simultaneous measurement of a diverse metabolite collection …
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Metabolic profiling of cyanobacterial extracts using multivariate data analysis for their anti-obesity properties
Background. Obesity has become a major health issue worldwide. Progression of obesity has been linked to numerous of comorbidities such as coronary heart disease, heart failure, hypertension and diabetes mellitus. The urge for new anti-obesity drugs with less adverse effects is apparent. …
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Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy
… application of the Raman spectroscopy phenotypic profiling method to; (i) microbial toxicity, (ii) ex-vivo organ perfusion, and (iii) subcellular location targeting. Real-time analytical methods for monitoring living biological systems will enable study of the physiological changes associated with …
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Profiling the metabolome using Fourier transform ion cyclotron resonance mass spectrometry, optimised signal processing, noise filtering and constraints methods
… this research study was to develop methods for metabolic profiling, a process involving the identification of metabolites present in biological samples, by applying Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Three novel methods were developed to improve the quality …
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Robot-trifle: A robotic system for automated combinatorial growth phenotyping
… This software package aims to streamline metabolic profiling by automating the extensive bookkeeping and manual labor required to perform dozens of independent growth experiments. The metabolic profile of an organism can help inform metabolic reconstructions, community metabolism analysis, …
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Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate to Promote Tumor Growth
… metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of dysregualted high grade serous epithelial ovarian cancers (HGSOC) are unknown.</p> <p>Materials and Methods: Following IRB approval, metabolic …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… cultivars of Catharantlws rosellS has prompted metabolic profiling studies to determine the variability of MIA accumulation of existing flowering cultivars, with particular focus on the vindoline component ofthe pathway. Metabolic profiling studies that used high performance liquid …
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Metabolic Engineering of a Cyanobacterium to Convert CO2, Water, and Light into a Cyclic Hydrocarbon
… Engineered cyanobacteria with re-wired metabolic pathways have recently been designed through genetic engineering, and they possess the unique ability to synthesize new chemicals and biofuels, which are secreted from their cells. Systems that utilize photosynthetic microbes for biofuel …
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Multiphoton microscopy for stain-free slide-free histopathology
… nonperturbative nature and intrinsic molecular profiling capability. Despite these advantages, conventional methods for label-free multiphoton imaging are burdened by limited contrast and efficiency of individual modalities as well as complex laser systems, which hinders this technology from …
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Early prediction of pregnancy disorders with machine learning guided Raman spectroscopy, and metabolomics.
… Raman spectroscopy (RS) can be used as a metabolic profiling technique for clinical samples in the first trimester to detect at-risk pregnancies. T-stochastic neighbor embedding (tSNE) is a machine learning technique that was used show visual separation of both disorders, while partial …
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Metabolic vulnerability in HER2-positive Breast Cancer
… lethal targets. TALDO1, a gene encoding a metabolic enzyme in the non-oxidative pentose phosphate pathway was identified from the screen. Metabolic profiling with isotope-labeled glucose was used to understand the mechanism. The profiling results indicated that TALDO1 was necessary for …
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A statistical framework for extraction of structured knowledge from biological/biotechnological systems
… pre-conditioning and plasma supplementation from metabolic profiling data to improve the bio-artificial liver (BAL) device;
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Metabolomics as a tool in the identification and production of new marine-derived antibiotics from sponges and endosymbiotic bacteria
… host sponge, as well as in the dereplication and metabolic profiling of other sponge-associated bacteria.24-Methylenecholesterol and two novel steroids, 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol, 5α,8α-epidioxy, all significantly active against Trypanosoma brucei and …
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Phosphorescent semiconductor nanocrystals and proteins for biological oxygen sensing
… respiration by all complex life making it a key metabolic profiling factor in biological systems. Tumors are defined by hypoxia (low pO2), which has been shown to influence response to radiation therapy and chemotheraphy. However, very little is known about spatio-temporal changes in P0 2 during …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… goal of this project was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively …
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An exploration of the mechanism of hydrophilic interaction chromatography (HILIC) and the application of HILIC in metabolomic profiling
… chromatography (HILIC) and its application to metabolic profiling. The effect of different mobile phase modifiers on the retention behaviour of acidic and neutral test probes was studied on silica gel based columns which confirmed the hypothesis that HILIC is due to a combination of hydrophilic …
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