Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"metabolic plasticity"”.
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
… assessed the nature of glycolysis and related plasticity in human retinal microvascular endothelial cells (HRMECs) exposed to in vitro conditions relevant to DR.HRMECs were obtained from human donors and were exposed to either normal glucose conditions of 5 m M D-glucose (NG), 20 m ML-Glucose + …
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… in the different GBM microenvironments. TICs plasticity is under the control of epigenetic modifications that, among others, regulate metabolic genes' expression. We have recently shown that Lysine Specific Demethylase 1 (LSD1) genetic and pharmacological inhibition employing the selective …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS within an integrative R-based analytical framework, we characterized metabolic …
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The role of glycogen Metabolism in the Adaptation to environmental Changes of the cyanobacterium Synechocystis sp. PCC 6803
… growth. Glucose supplementation induces metabolic adaptations and glycogen accumulation, with limited glycogen synthesis proving detrimental to photomixotrophic growth, causing significant metabolic and photosynthetic disruptions. Moreover, the work explores how nitrogen depletion and …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine methyltransferases–mediated post-translational modifications, and mitochondrial metabolic plasticity …
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Metabolic-response assessment of metastatic murine breast cancer in 2D and 3D cultures using intrinsic NADH as a natural biomarker
… we hypothesize that cancer cell metabolism and metabolic responses to external stimuli (e.g. drug treatments) are distinctly different in threedimensional (3D), tumor-like model as compared with that of the conventional 2D monolayer culture. To test this hypothesis, we employed two-photon (2P) …
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COMBINATORIAL EFFECTS OF DIET-MICROBIOTA INTERACTIONS ON HOST METABOLISM
Metabolic diseases and colorectal cancer (CRC) are increasingly prevalent conditions influenced by complex interactions between diet, host genetics, the gut microbiota, and interorgan communication. Here, we describe findings from three studies that collectively elucidate novel mechanisms by which …
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Molecular-genetic characterisation of arginine auxotrophy in the opportunistic human pathogen, Pseudomonas aeruginosa
… cellular response to the accumulation of these metabolic intermediates. Proteins involved in polyamine catabolism and transport of small molecules were up-regulated in AMB128, whereas many proteins involved in denitrification were down-regulated. In summary, this work demonstrates remarkable …
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Energetics of maize C4 physiology under light limiting conditions
… not affected by light quality. A comprehensive metabolic model highlighted the importance of both CO2 delivery pathways in maize. Further, metabolic plasticity allowed the balancing of ATP and NADPH requirements between BS and M. Finally, I tested the hypothesis that plants can modify their …
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The effects of metformin on the gastrointestinal tract
… respiration, metformin also limited the metabolic plasticity of intestinal cells to utilise other metabolic fuels, which instead relied almost exclusively on glycolysis. In summary, this study suggests that increased glucose uptake mediated by GLUT transporters and increased glycolysis …
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Environmental Metabolomics - Metabolomische Studien zu Biodiversität, phänotypischer Plastizität und biotischen Wechselwirkungen von Pflanzen
Ein genereller Ansatz zur Charakterisierung von biologischen Systemen bietet die Untersuchung des Metaboloms, dessen Analyse als „Metabolomics“ bezeichnet wird. “Omics”- Technologien haben das Ziel, ohne Selektionskriterien möglichst alle Bestandteile einer biologischen Probe zu detektieren …
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Impacts of ocean acidification and other (global change) stressors on marine invertebrates
… is a type of environmental reaction due to the plasticity of an organism. In this doctoral dissertation, studies have been carried out to understand the potential physiological or biochemical effects of some global change stressors on five important marine and estuarine invertebrates: the …
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The role of intrinsic and extrinsic factors in shaping alternative migratory tactics and metabolic phenotypes in brown trout
… anadromy). I explored how components of metabolic rate – a fundamental determinant of physiological status – varied according to food restriction and population background in Chapter 4. Standard metabolic rate (SMR) was lower in food-deprived fish, while SMR, maximum metabolic rate, and …