Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 421 for “"metabolic pathways"”.
-
Metabolic pathways of Campylobacter fetus
… But the non-oxidative portions of the former pathways were present in 482 and is believed to compose the major pathway of pentose-5-phosphate metabolism in this organism. There were activities of lactate dehydrogenase, reduced NAD and NADP dehydrogenases, and phosphotransacetylase found in …
-
Metabolic Pathways for Natural and Unnatural Sialic Acids
… is disrupted. Furthermore, I will discuss metabolic carbohydrate engineering as a valuable tool for studying sialic acid biology. Lastly, I will introduce an ancient and conserved family of proteins, the glycosyltransferases, which are responsible for transferring sugars, such as sialic …
-
Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion
… coupling. Therefore, better understanding of the metabolic events required for insulin release is likely to be helpful in development of more effective treatments for diabetes.</p><p>Previous work in our lab revealed a critical role for the pyruvate-isocitrate cycling pathway in glucose-stimulated …
-
Protein-protein interactions and metabolic pathways reconstruction of Caenorhabditis elegans
Metabolic networks are the collections of all cellular activities taking place in a living cell and all the relationships among biological elements of the cell including genes, proteins, enzymes, metabolites, and reactions. They provide a better understanding of cellular mechanisms and phenotypic …
-
Impact of metabolic pathways on ER+ metastatic breast cancer therapy response
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
-
Investigation of carbon fluxes in central metabolic pathways of Corynebacterium glutamicum
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
-
Development of metabolic pathways for the biosynthesis of hydroxyacids and lactones
In this thesis, metabolic routes were developed for the production of hydroxyacids and their lactones in multiple microbial systems. These compounds see widespread use in the production of pharmaceuticals, polymers, and fine chiral intermediates. First in this thesis, strategies and tools for …
-
Dynamic regulation of bacterial metabolic pathways using autonomous, pathway-independent control strategies
Metabolic engineering efforts have so far focused on strain optimization through careful metabolic modeling and tinkering with host genomes, through gene knockouts or knockins, to direct flux in desired channels. These efforts have borne fruit with the development of large manufacturing processes …
-
The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… reduction and is the fulcrum of anaerobic metabolic pathways more generally, here referred to as RQ-dependent metabolism (RQDM). In this thesis, I established a new methodology for inducing fumarate reduction in C.elegans with cyanide (KCN) which increases ease of study. I have found that …
-
THE EFFECTS OF ORAL ARGININE ON ITS METABOLIC PATHWAYS IN SPRAGUE-DAWLEY RATS
… the physiological impact of oral arginine on its metabolic pathways in the human body. As a versatile molecule, arginine is metabolized by multiple enzymes including arginase, nitric oxide synthase, arginine decarboxylase, and arginine:glycine amidinotransferase. Our lab has recently published a …
-
Comprehensive analysis of metabolic pathways through the combined use of multiple isotopic tracers
Metabolic Flux Analysis (MFA) has emerged as a tool of great significance for metabolic engineering and the analysis of human metabolic diseases. An important limitation of MFA, as carried out via stable isotope labeling and GC/MS measurements, is the large number of isotopomer equations that need …
-
Reconstruction of metabolic pathways by the exploration of gene expression data with factor analysis
… linkages between genes within a single metabolic pathway, or alternative pathway routes under different environmental conditions, or provide information leading to the identification of genes for selection in animal and plant genetic improvement programs or targets for drug therapy. Many …
-
Understanding the role of different strain types of Fusobacterium necrophorum: biofilms, glycans and metabolic pathways
Fusobacterium necrophorum an obligate Gram-negative anaerobe has been implicated in the cause of persistent severe throat infections and the systemic life-threatening Lemierre’s syndrome; a potentially fatal periodontal disease, which results in abscess formation in the tonsils. The use of …
-
USE OF BIOMETRICS TO DETERMINE BIOCHEMISTRY KNOWLEDGE LEVEL DIFFERENCES IN READING AND PROCESSING METABOLIC PATHWAYS
… schematics and representations for illustrating metabolic pathways is a familiar image in most biochemistry textbooks. These external representations can be the key to student understanding. To date, there has not been any previous research specifically focused on the areas of interest that are …
-
Metabolic Pathways of Amino Acids, Monosaccharides and Organic Acids in Soils assessed by Position-Specific Labeling
… labeling as a tool in soil science to trace the pathways of LMWOS transformations. In a mediumterm field experiment six position-specific 13C-labeled LMWOS from the three main LMWOS classes were applied: two amino acids (alanine and glutamate), two monosaccharides (glucose and ribose) and two …
-
Identification and characterization of genetic markers and metabolic pathways controlling net feed efficiency in beef cattle.
… Therefore, in an attempt to identify genes and metabolic pathways controlling feed efficiency in beef cattle, three different experimental approaches were taken herein: a) linkage and linkage disequilibrium quantitative trait loci (QTL) mapping for net feed intake in Lirnousin x Jersey animals, …
-
Macrophage Activation Profile and Phenotype Are Regulated by Metabolic Pathways and Are Altered by Diabetic Conditions
… the novel finding that one of the master metabolic pathways (CaMKK/AMPK) acts as a key regulator of macrophage activation by controlling the expression of CD86, CD11b, TNF-alpha and IL-10. Given the apparent importance of metabolic pathways in determining the macrophage activation profile, …
-
Single-cell transcriptomics identifies key components in metabolic pathways of drug perturbed activated CD4+ T cells
… During CD4+ T cell activation, remodelling of metabolic pathways is required for the cells to exert their effector functions. The importance of these pathways is highlighted by the successful therapies for immune diseases that target metabolic pathways. Although key metabolic processes have …
-
Metabolic detoxification of olefinic compounds: identification of mercapturic acids as a method in the elucidation of metabolic pathways of styrene and functionalized olefinic compounds
Contains fulltext : mmubn000001_026920840.pdf (Publisher’s version ) (Open Access)
Page 1 of 22