Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"metabolic pathway"”.
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Metabolic Pathway Optimization with Data Driven Approaches
… is determined by all the other enzymes in the pathway. Most kinetic rate laws for pathway models are generally nonlinear, which makes an analytical analysis virtually impossible. Previous studies have explored linearization under assumptions such as non-saturation, which limit all steps to the …
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Synthesis of thiohistidines and its metabolic pathway precursors
… ergothioneine and all its biosynthetic pathway intermediates, including deuterated versions thereof. A simple, short and high yielding novel process of the synthesis of ergothioneine was developed. Additionally, enzymatic methods were also considered for the desulfurisation step. The C-S …
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PathMeld: A Methodology for The Unification of Metabolic Pathway Databases
A biological pathway database is a database that describes biochemical pathways, reactions, enzymes that catalyze the reactions, and the substrates that participate in these reactions. A pathway genome database (PGDB) integrates pathway information with information about the complete genome of …
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Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer
… in fish oils, have anticancer effects. Two major metabolic pathways exist for arachidonic acid, namely the cyclooxygenase (COX) pathway and the lipoxygenase (LOX) pathway. Earlier investigations into the role of arachidonic acid metabolism in cancers focused mainly on the COX pathway, because of …
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Identification and Characterization of Genes Involved in Regulation of Ascorbate Metabolic Pathway(s) in Arabidopsis thaliana
Vitamin C (ascorbic acid, AsA), an important primary metabolite of plants, functions as an antioxidant, an enzyme cofactor, and a cell-signaling modulator in a wide array of crucial physiological processes including biosynthesis of the cell wall, secondary metabolites and phytohormones, stress …
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Identification and quantification of lipid metabolites in cotton fibers: Reconciliation with metabolic pathway predictions from DNA databases.
… lipid metabolite data was used to predict lipid metabolic pathways in cotton fiber cells.
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Reconstruction of metabolic pathways by the exploration of gene expression data with factor analysis
… linkages between genes within a single metabolic pathway, or alternative pathway routes under different environmental conditions, or provide information leading to the identification of genes for selection in animal and plant genetic improvement programs or targets for drug therapy. Many …
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USE OF BIOMETRICS TO DETERMINE BIOCHEMISTRY KNOWLEDGE LEVEL DIFFERENCES IN READING AND PROCESSING METABOLIC PATHWAYS
… schematics and representations for illustrating metabolic pathways is a familiar image in most biochemistry textbooks. These external representations can be the key to student understanding. To date, there has not been any previous research specifically focused on the areas of interest that are …
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Characterization of botryococcus sp. and identification of carbohydrates metabolic related enzymes toward lipid production
… production. This work is aimed at determining metabolic pathway and enzymes involved in carbohydrate metabolism of Botryococcus sp. The B. sp. from Taman Negara Johor Endau Rompin was isolated and identified. Some relevant intracellular metabolites were extracted and quantified through HPLC and …
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Mechanisms of Pteridine-Ommochrome Interactions in Drosophila Melanogaster
… is the end product of a seemingly unrelated metabolic pathway (Ziegler 1961; Kaufman 1967a). Mutations which alter the synthesis of these pigments are manifested as numerous variations in eye color (Lindsley and Grell 1967). Suppressed production of brown pigment results in the accumulation …
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Biosensor-based strategies for improving pathway production in Escherichia coli
… as nylons and used in detergents. An engineered metabolic pathway requiring three heterologous enzymes to convert glucose into glucaric acid in Escherichia coli was previously demonstrated by the Prather lab. Glucaric acid production has been shown to be limited by the two downstream enzymes …
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In silico systems analysis of biopathways
… have been produced; a number of specific genetic/metabolic databases and computational systems have been developed, which makes it possible for biologists to perform in silico analysis of metabolism. With experimental data from laboratory, biologists wish to systematically conduct their analysis …
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The uptake, distribution, and depuration of ¹⁴C benzene in Northern anchovy (Engraulis mordax) and Striped bass (Morone saxatilis)
… in tissues exhibiting a high lipid content (non-metabolic pathway) or representing apparent major metabolic sites were measured during the exposure and afterwards when the fish were transferred to clean seawater. Fish exhibited a rapid uptake over a wide range of benzene concentrations in the …
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Transcriptomic analyses of Clostridium beijerinckii NCIMB 8052 during transition from acidogenesis to solventogenesis and under butyrate supplemented conditions
… structure of important gene operons involved in metabolic pathways for acid and solvent production in C. beijerinckii 8052 were confirmed, including pta-ack, ptb-buk, hbd-etfA-etfB-crt (bcs) and ald-ctfA-ctfB-adc (sol) operons; important operons related to chemotaxis/motility, transcriptional …
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Investigations into the Metabolic Requirements for Lipoic Acid and Lipid Species During the Life Cycle of the Malarial Parasite Plasmodium Berghei
… a key enzyme in the lipoic acid synthesis pathway in the rodent species of malaria, Plasmodium berghei, we sought to investigate its role during the parasite life-cycle. Deletion of the lipoyl-octanoyl transferase enzyme, LipB in P. berghei parasites demonstrate a liver-stage specific need …
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Modeling heterogeneity in the microbial world
… focuses on how the stochastic expression of metabolic enzymes affects the growth and metabolic pathway usage of individual Escherichia coli cells. The second chapter deals with how E. coli cells in colonies diverge behaviorally as a function of their location, and how they naturally tend to …
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Systems metabolic engineering through application of genome-scale metabolic flux modeling
Systems metabolic engineering has enabled systematic studying of microbes for modifying their genetic contents, analyzing their metabolism, and designing new capabilities. One of the most commonly used approaches in systems metabolic engineering involves genome-scale metabolic flux modeling. These …
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System analysis and metabolic engineering of biocatalytic reaction networks : application to indene bioconversion
Metabolic engineering is a science concerned with the improvement of cellular properties through the application of recombinant DNA technology. To this point, the field has frequently been limited to methodological issues pertaining to gene introduction, expression and control by way of molecular …
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High resolution metabolic flux determination using stable isotopes and mass spectrometry
… are transcribed to proteins, which catalyze metabolic pathways, whose activity may in return affect gene expression. DNA microarrays allowed the measurement of the full gene expression profile under a particular set of environmental conditions and genetic backgrounds. To understand, however, …
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