Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"metabolic modelling"”.
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Genome scale metabolic modelling of Phaeodactylum tricornutum
… construction and analysis of genome scale metabolic models (GSMs) of Phaeodactylum tricornutum, a model diatom, the characterisation of physiological properties and the identification of the potential strategies to optimise the lipid production. GSMs were constructed based on a previously …
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Structural Metabolic Modelling of the Acetogen Acetobacterium woodii
… has been carried out on it. Here we construct metabolic models, including a Genome-scale Metabolic Model (GSM) of Acetobacterium woodii using the sequenced and annotated genome of strain DSM1030. The GSM consists of 867 metabolites, 841 reactions and 98 transporters and is predictive of growth …
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Genome-scale metabolic modelling of Salmonella and Lactobacillus species
… r^ole of metabolism in virulence, a genome-scale metabolic model of S. Typhimurium was constructed, based on genomic and biochemical data obtained from public databases. A method for modelling metabolic interactions between cells was developed and applied to models of S. Typhimurium and the …
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Genome Scale Metabolic Modelling of Arabidopsis thaliana and Chlamydomonas reinhardtii
… sequence for plants and algae. Genome scale metabolic models constructed from genome annotations represent the entire metabolic characteristics of the organism and can be used to integrate other data and study metabolic capabilities of the organisms under different conditions. This framework …
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Integration of metabolic modelling with machine learning to identify mechanisms underlying antibiotic killing
… of antibiotics relies critically on downstream metabolic effects, in addition to inhibition of primary targets. Here we present a novel computational pipeline to expedite investigation of these effects: we combine computational modelling of metabolic networks with data from experimental screens …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… applying innovative approaches for identifying metabolic drug targets in resistant pathogenic bacteria. In this thesis, genome-scale metabolic modelling (GSMM) was applied to identify antimicrobial drug targets. Experimental data from transposon mutant libraries grown in presence of tilmicosin, …
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Metabolic influences on ageing in Caenorhabditis elegans: A time series multi-omics and metabolic modelling study
… lifespan and promote healthspan are known to be metabolic and relate to managing the balance of energy availability to optimise resource usage and survival during times of scarcity. The model organism Caenorhabditis elegans, a small transparent nematode worm that ordinarily lives in the soil and …
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Omics-driven and constraint-based modelling of microbial community metabolism
… of microbial ecology, metagenomics, and metabolic modelling. More specifically, this thesis outlines the development and applications of omics-driven metabolic modelling approaches to understand microbial community metabolism in diverse ecological contexts. I begin by providing background …
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Computer modelling applied to the Calvin Cycle
This thesis developes computer modelling techniques, and their use in the investigation of biochemical systems, principally the photosynthetic Calvin cycle. A set of metabolic modelling software tools, "Scampi", constructed as part of this project is presented. A unique feature of Scampi is that it …
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Development of knowledge base and methodology for the rational microbiome modulation in irritable bowel syndrome
… Finally, I performed a systems biology-based metabolic modelling of microbiomes of the samples to evaluate changes in metabolic events, and inter-microbial metabolic interactions in IBS, followed by identification of species predicted as being capable of modulating the overall metabolic output …
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The Functional Cellular Identity and Interconversion of Human White, Beige, and Brown Adipocytes
… orthogonal treatment approaches. However, while metabolic changes in the form of increased energy expenditure in adipocytes form the core of this therapeutic potential, little is known about the metabolic differences between white and brown adipocytes, as well as the thermogenic beige adipocytes …
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Sucrose breakdown in the potato tuber
In dieser Arbeit wurden verschiedene Ansätze verfolgt, um das Verständnis des Saccharose-zu-Stärke Stoffwechselweges in sich entwickelnden Kartoffelknollen zu untersuchen. Zunächst wurde ein induzierbares Genexpressions-System aus dem Schimmelpilz Aspergillus nidulans für die Untersuchung des …
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Modelling metabolic landscapes in human naive and primed embryonic stem cells
… like) state and show the same differences in metabolic regulation. These two cell states also show major differences in their epigenetic landscape including in DNA methylation, repressive histone modifications, and spatial organisation of chromatin. I am interested in studying this metabolic …
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Metabolic engineering and modelling of Escherichia coli for the production of succinate
… a problem. To optimise succinate production via metabolic engineering, first a mutation strategy has to be developed. This strategy can then be applied to a suitable production host. The choice of this host has nowadays become less important due to the recent developments in genetic engineering …
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Method Development of 13C, 1H and 31P Magnetic Resonance Spectroscopy for use in Traumatic Brain Injury
… development, signal processing and mathematical modelling of in vivo metabolic fluxes within the brain. The first attempt at using [2-13C]glucose to quantify the in vivo neuronal tricarboxylic acid (TCA) cycle flux (VtcaN ) in humans is shown, accompanied with a Monte-Carlo error analysis to give …