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Showing 1 to 12 of 12 for “"metabolic inflexibility"”.
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The Role of Metabolic Inflexibility in Heart Failure
… leads to hypertrophic remodeling, accompanied by metabolic alterations. These changes are initially compensatory but lead to worse outcomes in the long term, making them targets for therapeutic intervention. When hypertension and diabetes are present simultaneously, a type of HF with preserved …
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Impaired Ulk1 Ser555 Phosphorylation Promotes Amino Acid Reliance and Links Mitochondrial Inefficiency to Systemic Metabolic Inflexibility
Metabolic flexibility—the capacity and ability to switch between energetic substrates in response to nutrient availability—is essential for systemic energy balance and protection against metabolic disease. Loss of this adaptive capacity contributes to metabolic diseases marked by obesity, insulin …
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
… (HFD), is part of a defect in obesity known as metabolic inflexibility. In severe obesity, ten consecutive days of aerobic training (short-term training) partially restores metabolic flexibility by increasing the ability of skeletal muscle to oxidize fatty acids. The purpose of this dissertation …
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Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism
Metabolic disease continues to be a worldwide problem that affects all ages, sexes, and socioeconomic statuses. The development of metabolic disease is multifactorial with both genetic and environmental components. Because of this, interest has grown in the early identification of individuals …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… obesity together form a cluster of interrelated metabolic challenges that may be linked by metabolic inflexibility. Metabolic inflexibility is characterized by the resistance to switching substrate oxidation preference based on substrate availability and can be measured in either fasted or …
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Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
… glucose response leading to a condition termed metabolic inflexibility. Finally, we imaged the nanoparticle-tissue interactions in tumor spheroids and found that incorporating affinity ligands onto nanoparticles and enhancing convective interstitial fluid flow through the tissue increased the …
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The Effects of a 5-Day High-Fat Diet on Skeletal Muscle O-GlcNAcylation
… with limited physical activity, can lead to metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity, insulin resistance, cardiovascular disease, and other chronic diseases. Metabolic flexibility of human skeletal muscles is influenced by changes to …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… fuel usage to nutrient availability is termed metabolic flexibility, and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) …
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Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… elevated inflammation levels often feature metabolic inflexibility and losses in skeletal muscle mass. Mononuclear stem cells, termed satellite cells, are mitotic and serve to donate nuclei to muscle fibers to enable skeletal muscle adaptation. Despite the well-characterized nature of …
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Association between the gut microbiota profile, fat oxidation capacity during exercise, and leptin sensitivity in patients with type 2 diabetes mellitus: The Edugution Project
Type 2 diabetes (T2D) is a cardiometabolic disorder characterized by chronic hyperglycemia due to insulin resistance or insufficient secretion. Individuals with T2D experience difficulties in the oxidation of fats and glucose, a phenomenon known as metabolic inflexibility, which negatively impacts …
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Blood Lactate Predicts Resting Energy Expenditure in Non-Obese Caucasian Females
… insulin resistance are co-morbidities with these metabolic disorders. However, it is unknown if those co-morbid traits are also displayed in the non-obese who may be predisposed to obesity. A higher plasma lactate concentration is the product of the shift to anaerobic glycolysis due to the …