Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"metabolic homeostasis"”.
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Activity Based Profiling: New Insights into Metabolic Homeostasis
… that demonstrates that body weight and energy homeostasis is tightly regulated by a physiological system. This system consists of sensing and effector components that primarily reside in the central nervous system and disruption to these components can lead to obesity and metabolic disorders. …
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NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… of this dissertation, we report surprising novel metabolic phenotypes that arise from modulating GRK2 activity exclusively in the heart. We show that transgenic βARKct (TgβARKct) mice (cardiac specific expression of a GRK2 inhibitory peptide) are more susceptible to high-fat diet (HFD) induced …
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The effect of circadian regulation and sleep disruption on metabolic homeostasis
Sleep and circadian disruption are ubiquitous in modern society. While the National Sleep Foundation recommends adults sleep 7-9 hours per night, the average sleep duration of American adults has decreased from ~8.8 hours to ~6.8 hours over the last century, with 1 in 3 people report sleeping fewer …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
Obesity and its associated metabolic comorbidities have become a global health crisis. The chronic expansion of the adipose tissue during obesity leads to a dysregulated microenvironment, characterised by hypoxia, fibrosis, and inflammation. The adipose tissue contains a vast repertoire of immune …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… network has emerged as a critical determinant of metabolic homeostasis and structural remodelling of this network is now widely accepted to contribute to the pathogenesis of obesity. However, the regulation of skeletal muscle capillary remodelling in obesity remains controversial and largely …
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The Pathophysiological Importance of Nicotinamide Phosphoribosyltransferase as a Key NAD Biosynthesis Enzyme in Metabolic Homeostasis
… function, including governing glucose homeostasis by lowering NAD levels in this tissue. Consistent with this notion, female ANKO exhibit severely impaired glucose tolerance and glucose-stimulated insulin secretion accompanied by hyperinsulinemia, and administration of NMN partially …
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Signaling pathways regulating skeletal muscle metabolism and growth
… maintenance of skeletal muscle and whole-body metabolic homeostasis. As satellite cells (SCs) play an indispensable role in postnatal muscle growth and adult regenerative myogenesis, we investigated the role of O-GlcNAcylation in SC function. To this end, we conditionally ablated OGT in SCs …
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FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS
The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is …
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Complex Oral Diagnosis of Children and Adolescents with Diabetes and Obesity /// Комплексна орална диагностика на деца и подрастващи със захарен диабет и затлъстяване
[EN] Correlations between diseases with metabolic disturbances and oral cavity state are carried out by means of various types of homeostasis (metabolic, immunological etc.), distortions of which lead to various diseases of the whole organism and the oral cavity as well. Diabetes mellitus (DM) is …
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An Investigation Into Splicing Variation and Expression Patterns of Insulin-Like Peptide 4 (ILP4) Within the Drosophila Genus
… pathway plays a crucial role in regulating metabolic homeostasis in both humans and insects. Dysregulation or mutation within this pathway can lead to various diseases, such as diabetes mellitus and insulin resistance. The insulin-like peptide 4 (ILP4) in Drosophila is an interesting subject …
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The host response to cancer and cancer-associated cachexia
… pathway of corticosterone, the main regulator of metabolic stress, and the pathway for detoxification of LPPs require NADPH as cofactor but their biochemical interdependency has not been explored. Using two murine models of cancer-associated cachexia, I demonstrate that KD slows down tumour growth …
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Examining physiological roles of adipose derived VEGF: Consequences in substrate availability and endurance exercise capacity in adipocyte specific VEGF deficient mice
… in adipose tissue alters adipose vascularity and metabolic homeostasis. We hypothesized that this would also affect metabolic responses during exercise-induced stress, and that adipocyte-specific VEGF deficient (adipoVEGF-/-) mice would have impaired endurance capacity. Endurance exercise capacity …
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ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… p53KO animals after APAP300 treatment. Impaired metabolic homeostasis, GSH transsulfuration and reduced expression of mitochondrial complexes in p53KO mice resulted in higher liver injury. However, increased inflammatory signaling and proliferative signaling through AKT, ERK and mTOR pathways …
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Differences in Gene Expression Responses to Heat Shock Between Warm- and Cool-Adapted Isolates of Batrachochytrium dendrobatidis
… pathogenicity as it prioritizes on maintaining metabolic homeostasis over infectivity. These findings provide more context surrounding species extinctions by investigating the adaptive potential of Bd and its ability to spread across varying environments.
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Involvement of Gdap1 In The Regulation of Mtorc1 Activity In A Drosophila Mliv Model
… 1 (mTORC1), is responsible for maintaining metabolic homeostasis by sensing nutrient and energy levels within the cell to promote or inhibit translation and autophagy accordingly. In the childhood neurodevelopmental disorder Mucolipidosis type IV (MLIV), mTORC1 activity is decreased. The …
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Single-cell Transcriptome Profiling Reveals Hedgehog Critically Regulates Hepatocyte Resiliency
… liver is responsible for maintaining systemic metabolic homeostasis, and also plays an important role in immune functions. Nutrients absorbed through the gastrointestinal tract are processed by the liver and are either stored or distributed to other organs to provide energy. When these …
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FATTY ACID SYNTHASE MODULATES MAMMARY GLAND LACTATION AND PROSTATE CANCER PROGRESSION IN VIVO
… in cells is heavily regulated to maintain metabolic homeostasis under normal physiological conditions. In contrast, cancer cells undergo numerous advantageous, metabolic alterations to promote the activation of the fatty acid synthesis pathway, and increase the expression of FASN. Through …
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Molecular Mechanisms by which a Grape Seed Procyanidin Extract Modulates Glucose Homeostasis
… are tightly regulated in order to maintain metabolic homeostasis. The hormone insulin, after binding to the insulin receptor, initiates a well-established controlled metabolic signaling cascade that consequently lowers blood glucose levels. There is considerable interest regarding effective …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… being established as a key player in whole-body metabolic homeostasis, we became interested in whether this ceramide accumulation in the brain is another avenue via ceramide accumulation during obesity causes its numerous deleterious effects. To study this, we have overexpressed acid ceramidase …
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