Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"metabolic gene expression"”.
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The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… increases energy expenditure and improves metabolic flexibility, but is also a key regulator of metabolic gene expression. Acute exercise stimulates a unique set of intracellular signalling cascades resulting in the activation of kinases which can subsequently control muscle metabolism. The …
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Effects of dietary stimulators of metabolism and mitochondrial biogenesis in vitro and in vivo: Implications for metabolic disease
… available dietary supplement on resting metabolic rate in humans as well as the metabolic and biochemical effects in vitro. Methods: Human rhabdomyosarcoma cells (RD) and mouse myoblasts (C2C12) were cultured under standard conditions and treated with various doses of a commercially …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… This inference has led to increasing interest in metabolic interventions to treat the diseased myocardium, termed metabolic modulation. However, the underlying molecular mechanisms directing cardiac metabolism and the changes occurring during pathogenesis are poorly understood. The chronic …
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… including the role of oxidative stress and the genetic basis of longevity. Progressive accumulation of oxidative damage to macromolecules is thought to underlie the aging-associated decline in physiologic function characteristic of the senescent phenotype. Mitochondria are a major intracellular …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… fuel usage to nutrient availability is termed metabolic flexibility, and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… predisposition of offspring towards cardiometabolic disease, whilst hearts of mice born to obese dams exhibit hypertrophic remodelling and contractile dysfunction. Programmed alterations in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in …
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Molecular mechanisms underlying avian metabolic variation: a genomic approach
… manifested from simultaneous changes in the expression of genes within hierarchical regulatory networks in response to temperature in the Dark-eyed Junco (Junco hyemalis). This transcriptomic variation resulted in rapid physiological modifications within individuals. In the second, I instead …
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Regulation and switching in bacterial gene expression networks in response to nutrients
… in an ever-changing environment? It is of general interest to understand cell decision making in response to environmental cues. One well-known strategy is phenotypical heterogeneity where different individuals inside a population utilize different niches and resources within the same …