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Showing 1 to 20 of 36 for “"metabolic flexibility"”.
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Room Calorimetry as a Method of Measuring Metabolic Flexibility
Metabolic flexibility is commonly measured as the change in respiratory quotient (RQ) from the fasted state to the insulin-stimulated state. This measurement is performed using a hyperinsulinemic-euglycemic clamp and hood calorimetry. A study was performed to evaluate if room calorimetry alone …
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Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism
Metabolic disease continues to be a worldwide problem that affects all ages, sexes, and socioeconomic statuses. The development of metabolic disease is multifactorial with both genetic and environmental components. Because of this, interest has grown in the early identification of individuals …
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Metabolic flexibility during exercise in overweight/obese children vs. lean children
Access to abstract permanently restricted
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
Metabolic flexibility plays a significant role in energy homeostasis by regulating fuel selection in correspondence to energy demand. Obese and type II diabetic populations have displayed a hindered ability to properly transition from fat oxidation while in a fasted state to carbohydrate oxidation …
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
… (HFD), is part of a defect in obesity known as metabolic inflexibility. In severe obesity, ten consecutive days of aerobic training (short-term training) partially restores metabolic flexibility by increasing the ability of skeletal muscle to oxidize fatty acids. The purpose of this dissertation …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… fuel usage to nutrient availability is termed metabolic flexibility, and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) …
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Influence of biological sex and thyroid hormone on skeletal and cardiac muscle metabolism in heat-stressed pigs
… because of inefficient metabolism and altered metabolic flexibility. The first study examined whether thyroid hormone (TH) administration during HS could maintain metabolic flexibility in HS skeletal and cardiac muscle. Gilts (n=39) were placed in one of five treatment groups: Thermoneutral …
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Prebiotic supplementation with inulin and exercise influence gut microbiome composition and metabolic health
… (T2D) is preceded by prediabetes, which is a metabolically "atypical" state associated with chronic low-grade inflammation, overweight and obesity, lack of exercise, and detrimental changes to the gut microbiome. Dietary intake and exercise are modifiable lifestyle factors for reducing T2D …
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The Effects of a 5-Day High-Fat Diet on Skeletal Muscle O-GlcNAcylation
… with limited physical activity, can lead to metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity, insulin resistance, cardiovascular disease, and other chronic diseases. Metabolic flexibility of human skeletal muscles is influenced by changes to …
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Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… for development of type II diabetes. These metabolic diseases are commonly associated with an accumulation of mitochondrial dysfunction, which is speculated to contribute toward insulin resistance. High-fat diets reduce human skeletal muscle insulin sensitivity and mitochondrial function. …
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The Influence of Heat Stress on Milk Yield, Gastrointestinal Permeability, and Nutrient Partitioning in Lactating Dairy Cattle
… could be influencing glucose sparing mechanisms. Metabolic flexibility of skeletal muscle, liver, and mammary tissue was assessed after 4 d of HS. It was determined that HS reduced skeletal muscle metabolic flexibility and did not alter liver and mammary metabolic flexibility. This indicates that …
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Nutritional Strategies to Improve Pig Growth and Performance
… and respiration and was detrimental to metabolic flexibility. Supplementation helped improve feed efficiency and maintain metabolic flexibility. These data indicate that supplementation may be an efficient strategy to mitigate heat stress.
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Impaired Ulk1 Ser555 Phosphorylation Promotes Amino Acid Reliance and Links Mitochondrial Inefficiency to Systemic Metabolic Inflexibility
Metabolic flexibility—the capacity and ability to switch between energetic substrates in response to nutrient availability—is essential for systemic energy balance and protection against metabolic disease. Loss of this adaptive capacity contributes to metabolic diseases marked by obesity, insulin …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… obesity together form a cluster of interrelated metabolic challenges that may be linked by metabolic inflexibility. Metabolic inflexibility is characterized by the resistance to switching substrate oxidation preference based on substrate availability and can be measured in either fasted or …
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Exploring the metabolic role of GPR30 in mice
… metabolism. However, GPR30 had no significant metabolic effects in male mice fed the HFD and both sexes of mice fed a chow diet. Further, GPR30 expression levels in fat tissues of WT obese female mice greatly increased, whereas ERα/β expression was not altered. Deletion of GPR30 reduced …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS within an integrative R-based analytical framework, we characterized metabolic …
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The Metabolic Effects of Low Grade Inflammation on Postprandial Metabolism Following a High Fat Meal
Inflammation is a central feature of various metabolic diseases including obesity and type-II diabetes. For this study, we hypothesized postprandial metabolism following an acute, high fat (HF) meal to be impaired in mice pre-injected with an inflammatory agonist. To this end, C57BL/6J mice were …
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The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… increases energy expenditure and improves metabolic flexibility, but is also a key regulator of metabolic gene expression. Acute exercise stimulates a unique set of intracellular signalling cascades resulting in the activation of kinases which can subsequently control muscle metabolism. The …
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The suitability of the microalgal metabolism for the recovery of nutrients from wastewater: the implications of solids residence time and diel cycles
… performance at the high SRTs used in this study. Metabolic flexibility, in particular carbon dynamics and predictable nitrogen and phosphorus recovery, makes microalgae a promising organism for the development of reliable, financially viable biological nutrient recovery systems.
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine methyltransferases–mediated post-translational modifications, and mitochondrial metabolic plasticity …
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