Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"metabolic dysfunction"”.
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Predicting Progression of Metabolic Dysfunction-associated Steatotic Liver Disease
This work focuses on the progression from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis, a more serious prognosis that can lead to liver failure and death. Additional adverse progressed outcomes include hepatic failure, fibrosis, cirrhosis, and …
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The Association Between Hepatic Steatosis and Glucose Metabolic Dysfunction
… metabolism through dysregulation of key glucose metabolic and insulin signaling pathways. Pigs (n = 6) were fed either MCFA or LCFA at high or low inclusion levels for 20 d in a 2 × 2 factorial design. Fractional body weight increased throughout the experimental period and was greater for pigs …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
<p>MECHANISMS OF CYTOKINE-INDUCED METABOLIC DYSFUNCTION OF THE PANCREATIC BETA-CELL</p> <p> by</p> <p>ABIY MUSSA MOHAMMED</p> <p>August 2013</p> <p>Advisor: Dr. Anjaneyulu Kowluru</p> <p>Major: Pharmaceutical Sciences</p> <p>Degree: Doctor of Philosophy</p> <p>Type I diabetes is characterized by an …
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Chronic prenatal ethanol exposure produces neurobehavioural and metabolic dysfunction in guinea pig offspring
… Disorder (FASD). Central nervous system (CNS) dysfunction is a debilitating and permanent manifestation of FASD. Recent studies indicate that chronic prenatal ethanol exposure (CPEE), via maternal ethanol administration, also impairs metabolic function in offspring. The mechanism of ethanol …
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The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
… that develops after injury. This surge develops metabolic dysfunction that is categorized by significantly elevated energy mobilization through increased glucose production and lipolysis. These metabolic changes contribute to the morbidity associated with delayed recovery. Hyperglycemia, …
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The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
… are associated with a compilation of serious metabolic side effects including weight gain, insulin resistance, fat deposition, glucose dysregulation and ensuing co-morbidities such as type II diabetes mellitus. The mechanisms underlying these side effects remain to be fully elucidated and …
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Prepartum Energy Intake and Its Relationship to Periparturient Inflammation and Metabolic Dysfunction in Dairy Cows
… intake and energy balance prepartum and improved metabolic profiles and health postpartum compared with cows having excess energy intake prepartum regardless of parity group. In experiment 5, a bovine oligonucleotide microarray was used to study temporal effects of mRNA transcript expression in …
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The Role of Adipose-Specific Free Fatty Acid Receptor 2 in Obesity and Associated Metabolic Dysfunction
Obesity and related metabolic disorders are often characterized by chronic adipose tissue inflammation, driving systemic insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2/GPR43) has emerged as a potential modulator of adipocyte function, inflammation, and …
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NON-INVASIVE METHODS TO PREDICT AND MONITORING METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE BY USING ULTRASOUND IMAGING
Metabolic-Associated Steatotic Liver Disease (MASLD) is becoming increasingly critical due to its rising global prevalence and its potential to progress to more severe liver diseases, such as Metabolic-Associated Steatohepatitis (MASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… burned patients is the activation of a hypermetabolic stress response, which is characterized by hyperglycemia, lipolysis, and protein catabolism. Perhaps the most serious gap in our understanding of the hypermetabolic response in burns is the role of the adipose tissue. Humans harbour two …
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Impact of mtDNA Signature on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression and Cardiometabolic Outcomes in Mice
Cardiometabolic diseases (CMDs) are a major global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as both a prevalent comorbidity and an independent risk factor for adverse outcomes. While diet and lifestyle are established contributors, variation in …
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Parallel Processes of Posttraumatic Stress and Metabolic Dysfunction: Long-Term Costs of Trauma on the Psychological and Physical Health of 9/11 Survivors
<p>Metabolic conditions (MetC) have been associated with posttraumatic stress disorder (PTSD) symptoms and may be critical indicators of the systemic physical sequelae of traumatic stress. Parallel process latent growth modeling wasapplied to longitudinal data collected from 35,788 9/11 survivors …
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Soft Tissue Composition, Cardiometabolic Risk, and Bone Development in Young Girls
… adiposity increases the risk for developing metabolic dysfunction, cardiovascular disease (CVD) and type 2 diabetes in adulthood. Far less attention has been focused on the effects of obesity during childhood on bone development. Obesity and skeletal fragility have been previously thought to …
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Characterizing the role of dietary fat in the development and progression of liver dysfunction
Obesity and metabolic dysfunction are worldwide health epidemics and they have grown to unprecedented levels. Human NAFLD is directly linked to obesity and metabolic dysfunction, so attention was given to elucidating a more complete understanding of the liver's role in mediating the metabolically …
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THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING
… at Southern Illinois University Carbondale. THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING MAJOR PROFESSOR: Dr. Andrzej Bartke It is well established that high calorie diets providing …
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
… million people in the United States. Cerebral metabolic dysfunction is a well-established feature of AD. Despite an established relationship between systemic metabolic disease and AD we know very little about how brain metabolism is impacted in diabetes or related metabolic conditions and how …
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RELATIONSHIPS BETWEEEN CARBOHYDRATE NUTRITION AND METABOLISM, INFLAMMATION, AND PERFORMANCE OF DAIRY CATTLE DURING THE PERIPARTURIENT PERIOD
… from pregnancy to lactation is a time of great metabolic adaptations for the dairy cow. Dry matter intake decreases, yet demand for nutrients increase vastly with the onset of milk production resulting in negative energy balance. Cows must mobilize body tissues to increase energy for the body …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
… AhR is also involved in dioxin-induced metabolic disorders and alteration of circadian rhythm. Furthermore, circadian clock disruption and metabolic dysfunction are integrally associated with each other. This study was designed to understand the mechanisms by which AhR contributes to …
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Účinek agonistů nukleárních receptorů (FXR, CAR, aj.) na játra a hepatocyty za různých stavů
… physiological and pathological conditions Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a substantial proportion of the global population, while currently available pharmacological treatment options remainlimited.Mitochondrialdysfunctionrepresentsone of the key …
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