Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"metabolic diseases"”.
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a read-out. In particular, compound SHS4121705 (2.12i) displayed an EC50 of 4.3 M in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the …
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PLANT BIOACTIVE COMPOUNDS FOR SUSTAINABLE NUTRITION AND PREVENTION OF METABOLIC DISEASES
Chronic metabolic diseases, including diabetes, obesity, and cardiovascular disorders, represent a significant global health challenge. Their prevalence continues to rise, necessitating innovative approaches to prevention and treatment. This work focus on bioactive compounds derived from legumes …
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Understanding the Aetiology of Metabolic Diseases and Related Phenotypes through Human Genetics
… clear links between protein functions and diseases. Another important method, Mendelian randomisation (MR), leverages genetic variants as natural experiments to investigate potential causal relationships between modifiable risk factors and diseases. This thesis used both approaches to …
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Representation Learning Associates Patients’ Risks for Metabolic Diseases with Features of Their Lipocytes
… into the cellular disease mechanisms. To study metabolic diseases, we analyze the distribution of cell states of lipocytes of individuals with different PRS for metabolic diseases, thereby associating individual-level genotypes with cell-level features. To accomplish this, we make use of a …
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Climate and disease with particular reference to certain metabolic diseases of the United States
Made available in DSpace on 2017-05-18T15:22:28Z (GMT). No. of bitstreams: 2 6341738_opt.pdf: 5461914 bytes, checksum: 14d66acd9d2f5e9f9fdb8e9a32e05e7a (MD5) license.txt: 4813 bytes, checksum: 715c4321821a960fa1a1e91d2ac7ebce (MD5) Previous issue date: 1951
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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans. Recently, NPC1L1 deficiency or ezetimibe treatment has been …
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
… is less efficacious and could cause or progress diseases such as obesity, type 2 diabetes, or metabolic dysfunction-associated liver disease (MAFLD). In response to the progression of these diseases, cells activate uncoupling proteins to increase the rate of mitochondrial respiration and reduce …
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Thylakoid membranes from green plants affect appetite and promote body weight loss
… proportions. Today, overweight, obesity and the metabolic diseases cause more death than starvation. To counteract an increasing body weight gain, regulation of appetite and a controlled food intake is of greatest importance. Simply put, body weight is regulated by the amount of energy ingested, …
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Investigating the role of the Renin Angiotensin System in cancer
… been discovered that cancer shares a link with metabolic diseases, including that of cardiovascular disease, diabetes, amongst others, where common sets of genes show similar gene expression. There is thus interest to investigate current therapies for metabolic diseases as possible anti-cancer …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
OBESITY AND ASSOCIATED METABOLIC DISORDERS ARE MAJOR THREATS TO PUBLIC HEALTH. THE MECHANISMS THAT LEAD TO OBESITY-ASSOCIATED METABOLIC DISORDERS HAVE NOT BEEN WELL UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES …
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Effects of an Endothelial Cell-specific PAR2 Knockout on Endothelium-dependent and -independent Relaxation of Mouse Arteries
… cells (EC), is a target in chronic inflammatory diseases. Understanding the functions of EC PAR2 will inform the development of PAR2-based therapeutics to treat endothelial dysfunction, a characteristic of cardiovascular and metabolic diseases. In this thesis, we used isolated blood vessels from …
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DESIGNING ANTI-PDL1 ANTIBODY CONJUGATED POLYMERIC COACERVATES AS A NOVEL “NANO-IMMUNOTHERAPY” AGAINST HEPATOCELLULAR CARCINOMA
… chronic viral hepatitis infections to that of metabolic diseases causing HCC, the number of HCC-related cases and deaths is expected to rise. While progress has been made in enhancing systemic therapies for HCC, resistance development and toxicity of these treatments are common. To circumvent …
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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
Infectious diseases are endemic in Africa, especially tuberculosis (TB), malaria and human immunodefiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Genomics research has the potential to improve the health of Africans through identification of genetic markers associated with either …
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Metabolomic Signature of Hypertension
… These metabolites are directly modified by the metabolic processes that are governed by organism’s genome, environment and diet. With advancement in technology, a large number of metabolites can be measured in various body fluids. The changes in metabolome precede disease phenotypes and thus, …
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Comprehensive analysis of metabolic pathways through the combined use of multiple isotopic tracers
Metabolic Flux Analysis (MFA) has emerged as a tool of great significance for metabolic engineering and the analysis of human metabolic diseases. An important limitation of MFA, as carried out via stable isotope labeling and GC/MS measurements, is the large number of isotopomer equations that need …
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A Transformer-Based Foundation Model for Human Microbiome Analysis
… chronic conditions like autoimmune disorders, metabolic diseases, and cancer. While various tools have been developed to study the microbiome, each tool tends to be specialized for a specific task. To overcome this limitation, we report on the development of a foundation model pretrained on …
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The impact of NOX4 deficiency on sexually dimorphic lipid handling in HFD-challenged mice
Dietary excess promotes metabolic dysfunction through nutrient overload. If sustained, it can impair physiological metabolic processes necessary for the proper handling of nutrients. Proper handling of nutrients depends on the capacity of an organism to properly sense, regulate, respond, and adapt …
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Nox4 mediates metabolic stress responses
… a wide variety of chronic skeletal muscle and metabolic-related diseases, including diabetes and sarcopenia. Even in patients with advanced skeletal muscle-related diseases, exercise is a well-established method to improve skeletal muscle mitochondrial metabolism, culminating in enhanced …
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Studium exprese mutantních alel a stavu X inaktivace ve vztahu ke klinickým projevům vybraných monogenních X vázaných onemocnění
… and traits in selected X linked inherited metabolic diseases is analysed, with the focus being Fabry disease - the deficiency of the enzyme alpha-galactosidase A encoded by GLA gene. Moreover, XCI in one family with X linked agammaglobulinemia is examined. Mutant alleles and XCI status …
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