Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"metabolic data"”.
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Optimised analysis and visualisation of metabolic data using graph theoretical approaches
… system. One method of tackling this problem, metabolic networks, is gaining popularity within the community as it offers a complementary approach to the traditional biological method for studying metabolism, the metabolic pathway. Construction methods are varied; ranging from the mapping of …
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Analysis of fatigue in firefighters: foot clearances over stair edges and validation of a novel means for metabolic data collection
… was modified to interface with a portable metabolic monitoring device (Cosmed K4b2). This design allowed for the collection of metabolic data while the firefighter utilizes a standard self-contained breathing apparatus (SCBA) as the air supply. This modified facepiece was then validated in …
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A data-driven neuromuscular model of walking and its application to prosthesis control
In this thesis we present a data-driven neuromuscular model of human walking and its application to prosthesis control. The model is novel in that it leverages tendon elasticity to more accurately predict the metabolic consumption of walking than conventional models. Paired with a reflex-based …
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Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
Mitochondria are metabolic hubs, with many diseases found to have altered metabolism and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of …
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Integrated characterization of cellular physiology underlying hepatic metabolism
The macroscopic metabolic phenotype of a cellular system, such as insulin resistance, is the result of the integration of many hundreds or thousands of preceding cellular events, which culminates in the cell's final response to a perturbation in the environment. The data provided by DNA microarrays …
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System analysis and metabolic engineering of biocatalytic reaction networks : application to indene bioconversion
Metabolic engineering is a science concerned with the improvement of cellular properties through the application of recombinant DNA technology. To this point, the field has frequently been limited to methodological issues pertaining to gene introduction, expression and control by way of molecular …
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Monitoring brain neurochemistry after brain trauma
… aid neurocritical care by through near real-time metabolic data, thereby facilitating timely and effective clinical interventions. * Study I (Chapter 4) confirmed that the EC-QCL MIR sensor can monitor changes in glucose concentrations in–vitro. - Study II (Chapter 5) demonstrated the practical …
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Frontal Plane Pelvic Drop in Runners: Causes and Clinical Implications
… between frontal plane pelvic drop and increased metabolic energy demands. Subjects were recreational runners who ran an average of five or more miles per week. Data from an initial ten subjects were collected, followed by an additional eleven subjects tested for Specific Aims #1, 2, and 3. GM …
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Enhancing human metabolic economy in stair climbing via an elastic crutch mechanism
… experience by helping patients attain a metabolic reduction compared to unassisted locomotion. Here, we present a foundation for achieving metabolic reduction with joint-spanning elastic elements. Our approach includes three parts. First, we present an augmented crutch design with an …
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Development and evaluation of biarticular transtibial prostheses for level-ground amputee walking
… while motion, force, electromyographic, and metabolic data were collected. Data were analyzed to determine differences resulting from the activation of each knee orthosis, compared to the orthosis behaving as a free-joint. We hypothesized that the active conditions would reduce joint kinetic …
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Digital Phenotyping and Genomic Prediction Using Machine and Deep Learning in Animals and Plants
… with deep learning models as well as large-scale data collected in commercial environments is still limited. Therefore, the first two research chapters show how deep learning-based computer vision systems can enable accurate live body weight prediction for dairy cattle and pigs. These studies also …
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Effect of a carbohydrate beverage on exercise performance in youth 7-17 years old
… of this study was to determine differences in metabolic measures (VO2, VE, & RER) between the carbohydrate and water performance trials in youth and adults. A third aim was to examine changes in metabolic measures (VO2, VE, & RER) throughout a 60-minute cycle ride in youth. It was hypothesized …
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The Effects of Cell Culture Oxygen Levels on the Replicative Senescence Processes of Primary Human Fibroblasts
… where cells undergo multiple changes in metabolic and cellular signaling pathways in order to prevent proliferation but still maintain a metabolically-active cell. Whether or not this model accurately reflects in vivo processes is presently controversial; however, replicative senescence …
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3D printing in Clinical Diagnostics: A Versatile Tool to Develop Testing Devices for the Diagnosis of Infectious Diseases
… for Grouping untargeted mass spectrometry data and open-source software tool to compliment the metabolic data acquired via the MCD. The 3D printed MCD that allows water-soluble metabolites to diffuse from a microbial culture well into a bacteria-free well through a semi-permeable membrane, …
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DEVELOPMENT AND APPLICATION OF NOVEL COMPUTATIONAL INTELLIGENCE TECHNIQUES TO THE MULTIVARIATE ANALYSIS OF METABOLOMICS BIOFLUIDS DATASETS
… requirement to further understand potential metabolic pathways involved in order to improve our understanding of the molecular mechanisms underlying NPC1 disease. NPC1 is a rare neurodegenerative disorder attributable to NPC1 gene function loss, which causes adverse fat storage at the …
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Pulmonary diffusion limitation, V̇ /Q̇ mismatch and pulmonary transit time in highly trained athletes during maximal exercise
… blood samples, mixed expired gas samples and metabolic data were obtained. Observed alveolar arterial difference ([A-a]D0₂(0)was calculated according to the alveolar gas equation. Indices of VA/Q mismatch: LogSDi and Log SDa and predicted [A-a]D0₂([A-a]DO₂(p)) were derived from 50 compartment …
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Interpreting Deep Learning for cell differentiation. Supervised and Unsupervised models viewed through the lens of information and perturbation theory.
… deep learning models. The combination of big data and computational power has nurtured the evolution of a variety of new methods to predict and interpret future scenarios. These data centric models can achieve exceptional performances on specific tasks, with their prediction boundaries …