Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"metabolic adaptations"”.
-
Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… inhibitor as a means of exploiting the metabolic vulnerability of glutamine dependence that develops as a result of adaptive resistance to AVA therapy.</p> <p><strong>Experimental Design: </strong>We used a glutaminase inhibitor (GLSi) synthesized at MD Anderson Cancer Center for all …
-
Skeletal muscle metabolic adaptations in response to an acute high fat diet
… variables, for example, diet, fitness level, or metabolic disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate balance happens quite …
-
Metabolic Adaptations of Ovarian Cancer Metastases to Physiological Conditions and Disease Progression
… a physiological environment that can impact the metabolic responses of ovarian cancer spheroids. Here, we investigated the metabolic adaptations of serous ovarian cancer cells across the metastatic cycle and in conditions that mimic those of the peritoneal cavity and malignant ascites. We first …
-
Comparison of short-term sprint interval versus traditional endurance training on metabolic adaptations in sedentary overweight/obese men
… interval training (SIT) has been shown to induce metabolic and performance adaptations that parallel those of traditional exercise recommendations (TER), and require considerably less time commitment. However, little is known about the effectiveness of short-term SIT in sedentary overweight …
-
Deciphering Metabolic Adaptations in Salmonella Enterica Serovar Typhimurium 14028S During Batch Growth and Gentamicin Exposure Using Absolute Quantitative Proteomics
… evidence suggests an intricate interplay between metabolic activities of the bacterium and the perturbations caused by antibiotics. To unravel this interplay, global analyses of bacterial responses to antibiotic treatment are required. In this thesis, we performed absolute quantification of the …
-
The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
… cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle metabolism. Intriguingly, skeletal muscle has been demonstrated to gain favorable inflammatory cytokine-mediated …
-
A Proteomics Approach to Investigate Uropathogenic Escherichia coli
… studies have reported the important role of metabolic adaptations in UPEC virulence. This study investigated the metabolic adaptations of UPEC isolates, with a focus on ST127, using a quantitative proteomics approach. We employed a classical shotgun proteomics approach to analyse proteins …
-
Impact of Dietary Carbohydrate and Protein Levels on Carbohydrate Metabolism
… tissue responses in gene expression and metabolic signaling in liver, muscle, and adipose tissue associated with diets containing 58%, 40%, or 25% of energy as CARB. These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution …
-
Computer modelling of metabolic adaptions during mitochondrial dysfunction and machine learning to predict novel mitochondrial disease genes
… cause. However, our lack of understanding of the metabolic adaptations to mitochondrial dysfunction limits the accurate screening of mitochondrial dysfunction for pharmaceutical companies, thus preventing potentially useful drugs from being developed. To further our understanding of these …
-
Investigation of chicken embryo metabolism and substrate utilization during later development
The objective of this research was to determine metabolic adaptations and substrate utilization during chicken embryo development and to determine the influence of breeder age and egg size on embryonic growth and metabolism during development (embryonic day 11 to posthatch day 1). In Study One, for …
-
The role of glycogen Metabolism in the Adaptation to environmental Changes of the cyanobacterium Synechocystis sp. PCC 6803
… growth. Glucose supplementation induces metabolic adaptations and glycogen accumulation, with limited glycogen synthesis proving detrimental to photomixotrophic growth, causing significant metabolic and photosynthetic disruptions. Moreover, the work explores how nitrogen depletion and …
-
The effects of exercise training on cardiac and peripheral function in men and women
… differently to exercise training, including adaptations in cardiac function. In younger men and women, training modality is also an important determinant of improvements in cardiac function, but the full effects of exercise training need to be determined both centrally and peripherally. …
-
Identifying Metabolic Liabilities in Hürthle Cell Thyroid Carcinoma
A metabolic hallmark of cancer identified by Warburg is the increased consumption of glucose and secretion of lactate, even in the presence of oxygen. Although many tumors exhibit increased glycolytic activity, most forms of cancer rely on mitochondrial respiration for tumor growth. Hürthle cell …
-
The effect of exercise on the utilization of dietary energy by the laboratory rat
… trained rats exhibited an increased resting metabolic rate and thermic response to food. Also, in work involving lkC_glucose feedings they appeared to oxidize the exogenous substrate more rapidly than sedentary counterparts. Some of the observed metabolic adaptations to the trained state were …
-
Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… survival, increased antibiotic resistance, and metabolic adaptations to the host environment. Second, I assessed the role of an inserted element containing an active methyltransferase in M. a. massiliense. Infection experiments with an isolate containing the inserted element (BIR1049wt) and a …
-
Intermittent fasting as a therapeutic strategy for alzheimer’s disease: behavioral and molecular evidence
… disease (AD) is characterized by impaired metabolic functions that disrupt neuronal function and contribute to cognitive decline in aging populations. This dissertation examines IF as a therapeutic strategy for AD, focusing on behavioral parameters and molecular evidence. Chapter 1 provides …
-
Structural Studies into the Mechanism and Organisation of Mammalian Respiratory Complex I
… human complex I disease mutations and its unique metabolic adaptations. Chapter 2 uses structural data from two high-resolution cryo-EM datasets (each up to 2.2 Å) of mammalian complex I in induced protonated and deprotonated states at a pH range where the enzyme retains biochemical stability to …
-
Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… fuel usage to nutrient availability is termed metabolic flexibility, and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) …
-
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
… ultrabasic conditions through biochemical and metabolic adaptations. However, it remains to be discovered how microorganisms have physiologically adapted to the serpentinite environment. Taxonomic characterization of novel isolates from different serpentinite habitats allows us to examine …
-
RELATIONSHIPS BETWEEEN CARBOHYDRATE NUTRITION AND METABOLISM, INFLAMMATION, AND PERFORMANCE OF DAIRY CATTLE DURING THE PERIPARTURIENT PERIOD
… from pregnancy to lactation is a time of great metabolic adaptations for the dairy cow. Dry matter intake decreases, yet demand for nutrients increase vastly with the onset of milk production resulting in negative energy balance. Cows must mobilize body tissues to increase energy for the body …
Page 1 of 2