Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"metabolic adaptation"”.
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… depleted of aSMA+ CAFs. We further examined the metabolic relationship between CAFs and cancer cells to arrive at a mechanistic understanding of the observed metabolic phenotypes in CAFs. Our work demonstrates that CAFs’ metabolic reprogramming can be triggered by hypoxia-induced epigenetic …
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Metabolic Adaptation at Lactogenesis in the Cow and Rabbit
Made available in DSpace on 2015-05-12T22:36:28Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7317601.PDF: 5840495 bytes, checksum: 5cb5cebe615521556624ee445d5c6c81 (MD5) Previous issue date: 1973
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… a potential role of this neural circuit in metabolic adaptation. Here, we found that chronic activation of ERαvlVMH neurons prevents diet-induced obesity (DIO), which is associated with increased BAT thermogenesis and core temperature. Additionally, ERαvlVMH activation induces torpor-like …
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CHARACTERIZATION OF PROTEOMIC CHANGES IN CROPS DURING METABOLIC ADAPTATION TO DIFFERENT NITROGEN INPUTS
… of the molecular mechanisms underlying plant metabolic adaptations to different nitrogen inputs. Among these, proteomics was largely and successfully applied to analyze various aspects, including the role of post-translational modifications and enzyme isoforms. The aim of this PhD project was …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
<p>Brain metastasis, which frequently arises from breast cancer, lung cancer, melanoma, and colorectal cancer, remains a severely unmet medical need and its incidence continues to rise while treatment options remain palliative. To better understand the biology underlying its aggressive, incurable …
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The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
… cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle metabolism. Intriguingly, skeletal muscle has been demonstrated to gain favorable inflammatory cytokine-mediated …
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Molecular and Physiological Adaptations to Weight Perturbation in Mice
… of relative adiposity sufficient to derange metabolic physiology in a manner that negatively impacts the health of the individual. While population-based cut points based on body mass index (BMI) are frequently used as a means of identifying such individuals, this is an imprecise approach …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS within an integrative R-based analytical framework, we characterized metabolic …
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Understanding the biochemical basis of temperature induced lipid pathway adjustments in plants
… glycerolipids are synthesized via two major metabolic pathways compartmentalized in the ER and chloroplast. Adaptive responses in membrane lipids include alterations in fatty acid desaturation, proportional changes in membrane lipids as well as molecular composition of each lipid species. In …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… low-oxygen microenvironment requires significant metabolic adaptation. However, little is known about stem cell metabolism, its regulation or its effect on stem cell function. We started our work by focusing on the most comprehensively characterized adult stem cell population, the hematopoietic …
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The effect of exercise on the utilization of dietary energy by the laboratory rat
… trained rats exhibited an increased resting metabolic rate and thermic response to food. Also, in work involving lkC_glucose feedings they appeared to oxidize the exogenous substrate more rapidly than sedentary counterparts. Some of the observed metabolic adaptations to the trained state were …
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Carbohydrate and Fat Supplementation in Grazing Mares and Foals
… been due to decreased absorption of calcium or metabolic and hormonal changes associated with adaptation to the different energy sources in the supplements. Milk composition of FF supplemented mares was influenced in ways likely to improve foal health. The FF supplemented mares had enhanced …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
… in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function during atrophic conditions. Autophagy is a highly conserved proteolytic pathway responsible for the …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… profiling of these lines highlighted the role of metabolic adaptation and immunosuppression as central determinants of lymphatic metastasis. Finally, other syngeneic breast cancer models were used to assess the validity of the above-mentioned findings across breast cancer subtypes. Molecular …
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Investigation of Proliferation Suppressors In Genetic Fitness Screens
… of proliferation suppression, as well as metabolic adaptation mechanisms. Finally, we have identified a short list of genes that have not been noted previously to have proliferation suppressor behavior, representing candidate tumor suppressor genes. Included in these novel hits are fatty …
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Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… proliferative capacity, invasiveness and metabolic adaptation typical of tumour cells to support cell growth. One of the major players in this process is Myc, which can promote tumorigenesis by triggering a metabolic reprogramming that allows cells to produce macromolecules, by modulating …
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Overcoming radioresistance by targeting p21 in cancer
… vesicles trafficking and proteostasis and metabolic adaptation and rewiring. Finally, using the p21 inhibitor UC2288 or p21-targeting siRNAs treatment in combination with radiotherapy, we demonstrated that p21 inhibition also sensitizes other p53 wild type tumors to radiation. These …
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Myocardial insulin resistance in experimental uraemia
… results in significant molecular, cellular and metabolic remodelling. Progression of LVH leads to the development of insulin resistance, a feature common to CKD and heart failure, further jeopardising survival of the uraemic heart.The aim of this thesis was to investigate the effect of uraemia …
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Investigating the effect of yeast and mineral dietary supplements during the periparturient period on the production, physical health, and innate immune system of dairy cows
… in late gestation to a rapid on-set of metabolic adaptation to meet the needs of lactation production. This homeorhetic phase requires the coordination of numerous hormones and tissues to mobilize fat for energy, stabilize mineral fluctuations such as calcium, and adjust the rumen …
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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science
… science provides powerful abstraction tools for metabolic networks. Cell metabolism is the set of chemical reactions taking place in a cell, with the aim of maintaining the living state of the cell. Due to the intrinsic complexity of metabolic networks, predicting the phenotypic traits resulting …
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