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Showing 1 to 20 of 25 for “"metabolic acidosis"”.
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The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock
Measures of the severity of metabolic acidosis (base excess) and of the severity of the underlying acid-base derangements (levels of lactate, chloride, albumin, and strong ion gap) have been used to differentiate survivors from nonsurvivors in various types of adult critical illness, including …
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Use of polyhalite mineral as an acidogenic product in the diets of close-up non-lactating dairy cows
… be fed as an acidogenic product to induce a metabolic acidosis and prevent clinical hypocalcemia in dairy cows after calving. The overall objective of this study was to determine if the use of polyhalite mineral in the diets of pre-partum non-lactating dairy cows was effective as an …
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Distal tubule bicarbonate reabsorption.
… by ammonium chloride treatment. During acute metabolic acidosis, the effects of sodium delivery, water reabsorption, inhibition of carbonic anhydrase, and addition of the anion channel blocker SITS were determined. In addition, bicarbonate reabsorption was assessed during recovery from …
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Modelling the respiratory control system in human subjects for excercise conditions
… of their temporal pattern and magnitudes. Also metabolic acidosis, which is negligible below the lactate threshold, cannot be neglected for exercise conditions that take the system above the lactate threshold. The current work has established a general model that applies for exercise conditions …
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Glutathione synthetase: Conserved residues of the substrate loop
… (hGS) deficiency causes hemolytic anemia, metabolic acidosis, 5-oxprolinuria and a total deficiency may be lethal. Three flexible loops (A, G and S) surround the substrates (ATP, glycine and γ-GC). Human glutathione synthetase is negatively cooperative to one substrate, γ-GC. The Substrate- …
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Classification of Foetal Distress and Hypoxia Using Machine Learning
… that are included in this study as indicators of metabolic acidosis are: pH level (which is a measure of the hydrogen ion concentration of blood to specify the acidity or alkalinity), as an indicator of respiratory acidosis; Base Deficit of extra-cellular fluid level and Base Excess (BE) (which is …
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On-Farm and Pre-Slaughter Management Approaches to Reducing Stress Response and Improving Pork Quality in Pigs
… high intensity handling model were subject to a metabolic acidosis condition that was characterized by a low blood pH and base-excess with high lactate production. Mg lowered (P < 0.05) blood lactate but was not able to prevent the metabolic acidosis in the high intensity handled pigs. The final …
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Effect of selected drugs on mitochondrial metabolism in an in vitro model of human skeletal muscle
… Typical features of the syndrome include metabolic acidosis, arrhythmias, ECG changes that are similar to those of Brugada syndrome, hypertriglyceridemia, fever, hepatomegaly, rhabdomyolysis, cardiac and/or renal failure. The risk of the syndrome increases with raising dose and duration of …
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ΕΠΙΔΡΑΣΗ ΤΗΣ ΑΝΑΠΝΕΥΣΤΙΚΗΣ ΔΥΣΧΕΡΕΙΑΣ ΣΤΟ ΜΕΤΑΒΟΛΙΣΜΟ ΤΟΥ ΦΩΣΦΟΡΟΥ ΣΕ ΝΕΟΓΝΑ ΚΑΙ ΒΡΕΦΗ
… NEONATESAND INFANTS, SUCH AS THE RESPIRATORY AND METABOLIC ACIDOSIS, THE STRESS DUE TOTHE DIFFICULTY IN BREATHING, THE IMMATURITY OF THE KIDNEYS, ENDOCRINOLOGICAL FACTORS AND THE INSUFFICIENT FEEDING. IN CONCLUSION PI ADMINISTRATION IN NEONATES AND INFANTS WITH R.D MAY HELP TO CORRECT THE PHOSPHAT …
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Búsqueda de interacciones off-target usando el fármaco Amiodarona como caso de estudio
… this drug: hepatic steatosis, oxidative stress, metabolic acidosis/diuresis, and pulmonary toxicity. The first three were obtained by BioGPS, the last was notified by means of a bibliographic search. With the results obtained, a new horizon opens up in the area of drug design and safety, with the …
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Acidosis and bone disease in chronic renal failure
… association of the osteomalacia with the chronic metabolic acidosis seemed at least as strong as with the degree of uraemia, raising again the old question of whether a causal connection existed between acidosis and renal bone disease. We know that most creatures exposed to direct sunlight have …
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Clinical characteristics of end stage renal disease patients at hemodialysis initiation
… (ER group). In the ER group, hyperkalemia and metabolic acidosis were significantly more severe than the OPD group. We hope our study will provide valuable information on the clinical and laboratory characteristics of the patients at the time of hemodialysis initiation in our current practices.
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Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth
… and reports the consequences for diagnosing metabolic acidosis (MA) at birth. Neonatal MA rates cannot be compared between maternity units or between scientific articles where different fetal compartments (blood or extracellular fluid) and different algorithms for calculating BD have been …
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Carnosine metabolism and function in the thoroughbred horse
… buffering capacity, which may reduce the rate of metabolic acidosis during high-intensity exercise, and possibly delay the subsequent onset of localized muscle fatigue.
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The role of fish physiology, behaviour, and water discharge on the attraction and passage of adult sockeye salmon (Oncorhynchus nerka) at the Seton River dam fishway, British Columbia
… that failure was probably not related to metabolic acidosis.
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Factors Affecting Deficiency and Toxicity of Sulfur-Containing Compounds
… of acid-base balance. Thus, excess Cys led to metabolic acidosis within 12 hours of feeding and was ultimately lethal. The growth depressive and lethal effects observed in chicks consuming 2.5% excess Cys were ameliorated through provision of dietary potassium bicarbonate and hydrogen peroxide, …
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Functional analyses of ζ-crystallin binding to the 3'-UTR of glutaminase (GA) mRNA
Chronic metabolic acidosis is associated with increased expression of renal glutaminase (GA) that results from selective stabilization of the GA mRNA. LLC-PK1- FBPase+ cells, a pH-responsive porcine kidney cell line, express four distinct GA mRNAs, that are ~2.5, 3.5, 4.5, and 5.0 kb in length. …
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Effects of feeding moderate-energy high-forage diets with reduced DCAD for twenty-one or forty-two days prepartum on mineral homeostasis and postpartum performance
… dry period. Supplementing anions induced a metabolic acidosis reducing urine pH for 21-ND and 42-ND compared to CON. Prepartum DMI was not affected by prepartum anionic supplementation. Postpartum DMI tended to be higher for anionic diets than the control diet (20.1 vs. 18.1 kg/d). Prepartum …
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… hyperkalaemia, hyperchloraemia with compensated metabolic acidosis and growth retardation, which closely recapitulates human PHA2E. The discovery of increased vascular tone suggests an explanation for the severity of CUL3$^{\Delta}$$^{ex9}$PHAII. In mice, homozygous MO25$\alpha$ knock-out proved …
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Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells
During metabolic acidosis, the level of glutaminase (GA) is increased 8-fold within the renal proximal convoluted tubule. This adaptation contributes to the ability of the kidney to generate NH4+ and HCO3- ions from glutamine to facilitate the excretion of acids and partially restore acid-base …
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