Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"messenger ribonucleic acid"”.
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Modeling and analysis of gene expression arrays
… are a technology used to measure quantities of messenger ribonucleic acid (mRNA). Application of the technology involves a variety of physical processes beginning with the acquisition of mRNA samples and ending with the fluorescence imaging of a gene expression array. This thesis examines these …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription factor regulating lipogenic gene expression. The objective of this study is to further …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… detecting and quantifying levels of HERV-W env messenger ribonucleic acid (mRNA) and MSRV gag by reverse transcriptase polymerase chain (RT-PCR) reaction in a variety of cell lines was developed, with PCR products detected in all cell lines tested, and in particular, high levels of transcription …
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Mechanisms of pain processing: spinal protein translation in the rat
… pain nociceptors is the realisation that messenger ribonucleic acid (mRNA) in dendrites, axons, axon terminals as well as cell bodies, is essential for long-term synaptic plasticity and may therefore be important in pain processing. The protein kinase mammalian target of rapamycin (mTOR) …
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Interaction of ACTH and Estradiol in the Regulation of Growth, Differentiation, and Steroidogenic Maturation of the Baboon Fetal Adrenal Gland
… of, as well as ACTH receptor and P-450 enzyme messenger ribonucleic acid and/or protein levels in the baboon fetal adrenal are dependent upon fetal pituitary ACTH during mid and late gestation and the mechanism by which placental estrogen modulates ACTH actions. Administration of betamethasone …
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The nature of cachexia in patients with heart failure and stable coronary artery disease
… biopsies were analysed for the expression of messenger ribonucleic acid (mRNA) for TNF-α, IL-6, interleukin-1β (IL-1β), interleukin-18 (IL-18) and the cell cycle inhibitors (cyclin dependent kinase (CDK) inhibitors) p21, p27 and p57. We found that the HF-cachexia group had significantly lower …
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Biopolymer-Hybrid Nanomaterials for Vaccine Formulation
… to render the NPs suitable for efficient nucleic acid immobilisation. Within this thesis, the preparation, functionalisation and characterisation of well-defined PDA NPs containing cationic amino acids, peptides and polymers, as well as their application as non-viral gene delivery vectors were …
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Targeting heart rate as a novel therapeutic approach in acute heart failure
… after the second TTE for histology staining and messenger ribonucleic acid (mRNA) quantitation of transcripts involved in heart failure. (3) To explore the role of the sinoatrial node inhibitor in an ex-vivo model of de-novo AHF due to hypotension, and a newly developed ex-vivo model of TC. In …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… cell-free DNA, circulating tumour DNA, cell-free messenger RNA, and bloodborne tumour related proteins as disease biomarkers in patients with glioma and metastatic melanoma. The in vivo research work employed an animal model to study micro RNA mediated epigenetic regulatory mechanisms implicated …
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Generation of cDNA libraries of amoeba, 8 hour, and 12 hour stages of Dictyostelium discoideum
A critical event during the life cycle of Dictyostelium discoideum is glycogen turnover. This process is catalyzed by glycogen phosphorylase-2 (gp-2). Since gp-2 expression is first induced during the transition from growth to differentiation, understanding how this gene is controlled may provide …
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Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants
… was preserved in PAXgene fluid for downstream messenger ribonucleic acid (mRNA) transcript analyses. Other whole blood samples were fixed and cryopreserved either directly ex vivo or after re-stimulation within 1 hour of phlebotomy with BCG, Tetanus Toxoid (TT), Bordetella pertussis (BP) …
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Discrete elements of the U2 snRNP regulate its intranuclear trafficking and recruitment to nascent transcripts
In this study, I characterize the elements of the U2 snRNP that control its intranuclear trafficking and association with nascent transcripts. Through a mutational analysis, I demonstrate that stem loops 3 and 4 (SL3 and SL4) are both required for U2 snRNP association with nascent transcripts and …
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Collective Evolution of Biological and Physical Systems
… the frozen accident theory assumes, every amino acid substitution is lethal at least at some genome sites. This research shows that it is possible to account for the optimality of the code within the framework of translation as a standardized competition between tRNA adaptors. Finally, I …