Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"mesothelioma"”.
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Stromal interactions in pleural mesothelioma
Pleural mesothelioma (PM) is a devastating malignancy primarily related to past asbestos exposure. There are no curative options, and 1-year survival stands currently at just 40%. The genomic landscape in mesothelioma is dominated by loss of function of tumour suppressor genes rather than …
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The experience of mesothelioma in Northern England
Mesothelioma is a potentially preventable fatal disease causing almost 2000 deaths/year in the UK, increasing in incidence, and lacking effective treatments. ‘The Experience of Mesothelioma in Northern England’ is a community-based, mixed methods, case study in four parts, conducted in …
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Zirconium-based Metal-Organic Frameworks for Pleural Mesothelioma Therapy
… to improve the treatment of malignant pleural mesothelioma, an incurable cancer with a survival time of only one year after diagnosis. Mesothelioma is mainly caused by exposure to mining asbestos, a natural fibre widely used in building constructions. This untreatable cancer is histologically …
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A case-control study of mesothelioma in South Africa
… a prospective multicentred case-control study of mesothelioma carried out in South Africa. The objectives of the study were: 1) to examine asbestos exposure of cases in detail with respect to source, risk occupations, fibre type and duration; 2) to determine relative risks for level (certainty) of …
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Prognostic models for mesothelioma : variable selection and machine learning
Malignant pleural mesothelioma is a rare and lethal form of cancer affecting the external lining of the lungs. Extrapleural pneumonectomy (EPP), which involves the removal of the affected lung, is one of the few treatments that has been shown to have some effectiveness in treatment of the disease …
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The significance of the EGFR pathway in malignant pleural mesothelioma
… and COX2 are up regulated in malignant pleural mesothelioma (MPM). In this study we aimed to determine the expression of Lipoxygenase enzymes (LOX), absence of PTEN protein expression and the cytotoxic effect of EGFR, MTOR and COX2 inhibitors in MPM.Materials and MethodsImmunohistochemical …
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The emerging roles of BAP1 and cancer stem cells in Malignant Mesothelioma
Malignant Mesothelioma (MMe) is an aggressive asbestos-related cancer with a poor prognosis and the standard treatments are not effective. The lack of successful therapies is due to several factors, including the poor knowledge of mesothelioma biology. In this thesis, several biological aspects …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
Background: Malignant Mesothelioma (MM) is a malignancy related to asbestos exposure which causes a wide variety of molecular aberrations. MM has a very dismal treatment outcome with an overall survival of fewer than 12 months, with less than five drugs available for its treatment. MM recurrence is …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
Normal cellular homeostasis is established and maintained by the positive and negative regulatory activities of many genes. When these genes are mutated to forms that can contribute to tumorigenesis, either by dominant, gain of function mutations in positive regulators or recessive, loss of …
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In vitro and in vivo investigation of the anticancer activity and mechanism of disulfiram in malignant mesothelioma
Background Malignant Mesothelioma (MM) represents an asbestos-related insidious and invasive neoplasm with a long latency period. MM carries a dismal prognosis as most patients have irresectable disease or are ineligible for surgery due to medical comorbidities or old age, leaving chemotherapy and …
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“I am the Outlier on the Graph”: An Exploration of the Experiences and Coping Strategies of People Under 60 Living with Pleural or Peritoneal Mesothelioma Using Interview and Photo-elicitation Methods
Mesothelioma is a terminal cancer that typically affects the lungs; however, it can affect the abdomen, as well as the heart and testes in even more rare cases. It is primarily caused by exposure to asbestos; and as a result, is generally more common in older male individuals -over the age of 70- …
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