Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"mesolimbic dopamine"”.
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Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit
… we identify signature adaptations within the mesolimbic dopamine circuit that are uniquely associated with vulnerability and, by a combination of viral-mediated gene transfer and genetic mouse models, we demonstrate how these adaptations are causally linked to a vulnerable phenotype. We also …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the effects of high-dose, chronic MPH exposure have not been well defined. In particular, …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… of maternal behavior in juvenile offspring. The mesolimbic dopamine system is also critically implicated in adult maternal behaviors, and was hypothesized to be responsive to variation in maternal LG. A second series of studies demonstrate that low or high levels of maternal LG predict levels of …
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
… of schizophrenia may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking …
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Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
… systems. Considerable evidence suggests that the mesolimbic dopamine system is the primary substrate for the acute rewarding and reinforcing effects of alcohol. Over time, excessive alcohol intake causes chronic functional changes in this system that may trigger off the transition from controlled …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… techniques were used to assess extracellular dopamine levels in the shell of the nucleus accumbens, the terminal region for mesolimbic dopamine neurons originating in the ventral tegmental area. The injection of atropine methyl nitrate into the ventral tegmental area elevated extracellular …
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Phasic Dopamine Signaling During Ingestion: Modulation Across the Need-to-Satiety Arc
… aimed at consuming the needed stimulus. The mesolimbic dopamine system plays a key role in driving and reinforcing such behaviors. While it is well established that physiological need states potentiate dopamine responses to relevant stimuli, less is known about how ongoing ingestion and the …
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Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury
… one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown.
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
… receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that CB<sub>1</sub> receptors are important to the …
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Parkinson's disease and the influence of the forebrain dopaminergic system on dreaming
… by Solms (2000) to the effect that a forebrain dopaminergic mechanism is the final common path to dreaming. It was hypothesised that sufferers of Parkinson's disease (PO) would have decreased intensity and frequency of dreams - that is that PO disease may lead to cessation or reduced dreaming, …
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Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
… hypothalamic system and projects to the mesolimbic dopamine reward system. The lateral parabrachial is molecularly diverse and expresses the acetylcholine synthesis enzyme: choline acetyltransferase (ChAT). In this study, we used ChAT-CRE mice to investigate the anatomical projections, …
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REGULATION OF DOPAMINE TERMINAL RELEASE IN THE NUCLEUS ACCUMBENS: IMPLICATIONS FOR ALCOHOL ADDICTION
… substance abuse despite adverse consequences. Dopamine signaling in the nucleus accumbens is thought to encode reward and reinforcement, and aberrations in dopamine signaling are suggested to mediate some of the maladaptive motivational behaviors associated with addiction. Measuring dopamine …
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Individual Differences in the Dopaminergic Reward System: The Effect of Genetic Risk on Neural Reward Sensitivity and Risky Choice
… make risky choices. Rewards are processed in the mesolimbic dopamine reward system, and this system is in part modulated by genetic polymorphisms that are associated with dopamine transmission. The current study tested if genetic polymorphisms that are associated with enhanced dopamine …
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Lateral hypothalamic control of motivated behaviors through the midbrain dopamine system
… activation of the GABAergic component causes dopamine release downstream in the nucleus accumbens via disinhibition of VTA dopamine neurons through VTA GABA neurons. Together, these experiments have profoundly elucidated the functional roles of the individual circuit components of the greater …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
Background: Mesolimbic dopamine controls drug and alcohol seeking behavior. Stimulation of dopamine D3 autoreceptor reduces extracellular levels of dopamine. We tested the hypothesis that dopamine D3 receptor (D3R) gene deletion or its pharmacological blockade counteracts alcohol preference and …
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Dopaminergic modulation of risk-based decision making
Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations about effort-related costs associated with larger rewards. However, the role of DA in risk-based decision making remains relatively unexplored. The present study …
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Cognitive Neurostimulation: Learning to Volitionally Invigorate Mesolimbic Reward Network Activation
<p>The brain’s dopaminergic system is critical to adaptive behaviors, and is centrally implicated in various pathologies. For decades, research has aimed at better characterizing what drives the mesolimbic dopamine system and the resulting influence on brain physiology and behavior in both humans …
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Taurine and dopamine-related effects of ethanol. An experimental study in rodents
… (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought to be a predominant underlying factor in promoting excessive alcohol intake and alcohol use disorder. We have …
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ETHANOL INHIBITION OF DOPAMINE TRANSMISSION IN ANIMAL MODELS OF ALCOHOL ABUSE LIABILITY
Mesolimbic dopamine neurons, originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc), have been heavily implicated in the reinforcing and rewarding properties of natural and drug rewards and cues that predict these rewards. Ethanol's effects on dopaminergic …
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