Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 253 for “"mesenchymal transition"”.
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Gene regulatory networks controlling an epithelial-mesenchymal transition
Epithelial-mesenchymal transitions (EMTs) are fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… is yet undetermined. We surmised that epithelial-mesenchymal transition (EMT) of hepatocytes might contribute to both hepatocyte dysfunction and liver fibrogenesis. To address this issue, hepatocytes were isolated from normal rat liver and from dimethylnitrosamine (DMN)-induced fibrotic rat …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… foundations of many organs. Epithelial Mesenchymal Transition (EMT) has been linked to malignancy in many carcinomas of epithelial origin. In this study, I look at the role of PC3 (Prostate Cancer cell line) derived MVs in the induction of EMT in PNT2 (normal prostate) cells. Uptake of …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
… that kill, not the primary tumor. The Epithelial-Mesenchymal Transition (EMT) provides a model by which tightly associated epithelial cancer cells can disseminate to distant sites. Many factors are known to trigger the EMT, but the extent to which the observed phenotypes represent a common process …
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Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… and cell motility, as gained by epithelial-to-mesenchymal transitions (EMT), to occur. In pum1 morphants, both the presentation of wild-type signaling gradients and EMT events are inhibited. Through in silico and in vivo analysis, acvr1b, an Activin receptor, was identified as a target for …
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PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
Background: Epithelial-mesenchymal transition is a critical early event in the invasion and metastasis of many cancers, including colorectal cancer. Chronic inflammation is an inducer of several cancers and inflammatory cytokines have been implicated in tumor invasion. Materials and Methods: Human …
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… of which partially underlined by the epithelial-mesenchymal transition (EMT). While the role of Warburg metabolism has been recognised in supporting rapid cellular growth and proliferation in many cancer types, less is known about the metabolic changes occurring during EMT, particularly in the …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… through induction of the epithelial to mesenchymal transition (EMT). EMT is a latent embryonic program that is aberrantly induced in breast cancer cells conferring migratory and invasive capabilities in addition to cancer stem cell (CSC) properties. In normal adipose tissue, FOXC2 …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… lung cancer cells undergo an epithelial-to-mesenchymal transition (EMT) that is regulated by a double-negative feedback loop between the transcription factor Zeb1 and the microRNA-200 family (miR-200). Furthermore, these studies demonstrated that mesenchymal lung cancer cell invasion and …
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
<p>Metastasis is the ultimate cause for the majority of cancer-related deaths. The forkhead box transcription factor FOXC2 is known to be involved in regulating metastasis as well as a variety of developmental processes, including the formation of lymphatic and cardiovascular systems. Previous …
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Investigating the relationship between miRNA expression and epithelial mesenchymal transition in colorectal cancer
Introduction: Epithelial-mesenchymal transition (EMT) is characterized by the loss of an epithelial phenotype and gain of a mesenchymal phenotype, i.e., migratory and metastatic properties. The EMT process is therefore characterized by a low expression of E-cadherin and high expression of …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
… a strong correlation with this kinase in mesenchymal-like cells. Inhibition of ZAK reversed the mesenchymal phenotype, and overexpression of ZAK resulted in epithelial-mesenchymal transition (EMT). Analysis of The Cancer Genome Atlas (TCGA) data shows a strong correlation between ZAK …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
… due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are essential during metastasis. Many transcriptional gene programs are altered during EMT such …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… heart disease is partly mediated by epithelial-mesenchymal transition (EMT) differentiation whereby epithelia acquire fibrotic biomarkers such as desmin, S100A4 and α-smooth muscle actin. In lung fibrosis this has not been characterised, further the molecular mechanisms in the lung are poorly …
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… contribution of epithelial to mesenchymal transition program on KRAS<sup>G12D</sup> targeting efficacy in pancreatic cancer</strong></p> <p>Ana S. Maldonado, BS</p> <p>Advisory Professor: Raghu Kalluri, M.D., Ph.D. </p> <p>Pancreatic Ductal Adenocarcinoma (PDAC), a highly …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… cells elicits an “irreversible” epithelial to mesenchymal transition (EMT) via activation of EMT-associated transcription factors, leading to a delay in wound healing process <em>in vivo</em>. Moreover, my work revealed pleiotropic roles of ΔNp63 as either a tumor suppressor or an oncogene in …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… characteristics, one of which is Epithelial to Mesenchymal Transition (EMT). EMT is the mechanism by which an epithelial cell gains the motility to migrate throughout the body by shifting from a stationary epithelial phenotype to a migratory mesenchymal phenotype. The aim of this study was to …
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