Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"mesenchymal stromal cell"”.
-
Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where …
-
Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… pharmacological therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of these …
-
Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
Mesenchymal Stromal Cells (MSC) are adult multipotent cells that possess self-‐renewal and regenerative capacities, with the ability to differentiate into a variety of cell types. They have potent immunosuppressive abilities, facilitating the use of allogeneic MSC as a cellular therapy. …
-
Investigating the efficacy and mechanism of action of mesenchymal stromal cell therapy in burn wound healing
Several studies suggest that mesenchymal stromal cell (MSC) therapy may be efficacious in accelerating wound healing. Which source of MSC is therapeutically superior has not been well established, especially in large clinically relevant animal models. We therefore investigated the efficacy of Bone …
-
An Investigation of The Effect of Hypoxic Culture on Mesenchymal Stromal Cell Immunomodulation and Biodistribution in-vivo
… to investigate the effects of hypoxic culture on mesenchymal stromal cell (MSC) immunomodulation and biodistribution in-vitro and in-vivo. Thus far, MSC have proved therapeutically beneficial for a number of inflammatory diseases such as acute Graft versus Host Disease (aGvHD). However, despite …
-
A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease
The potent immune regulatory capacity of mesenchymal stromal cells (MSC) has been extensively characterised in terms of T cells, natural killer cells and dendritic cells suppression; however the ability of MSC to modulate B cell biology is not fully understood. This immune suppressive ability has …
-
Lung microenvironment plays a key role on the protective vs. detrimental effects of mesenchymal stromal cell therapy in acute lung injury
… present complications of pulmonary fibrosis. Mesenchymal stromal cells (MSC) are considered good candidates for therapy due to their ability to home into injury sites and help in recovery. However, MSC are sensitive to stimulations from their surroundings and some evidence suggests that MSCs …
-
The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… of work was to determine the method of action of mesenchymal stromal cell immunomodulation, and their potential benefits in treating pulmonary fibrosis. This was achieved through a series of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. …
-
Engineering Dynamic Granular Composites for the Repair of Cartilage Tissue
In recent years, mesenchymal stromal cell (MSC) cellular aggregates, known as MSC spheroids, are being used as ‘building blocks’ to generate engineered tissues. MSC spheroids can fuse together to produce high cell density, macroscopic tissues with enhanced functional properties; however, their …
-
Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… these challenges, we designed a novel local mesenchymal stromal cell (MSC) based immunotherapy to study the immune tumor microenvironment (TME), and optimized radiotherapy delivery with cGAMP and systemic α-PD-L1 immunotherapies. Using MSC, we delivered various forms of anti-CD3 and/or …
-
Bone Regeneration Potential of Mesenchymal Stromal Cells derived from a Clinically Relevant Rat Model of Osteoporosis
… of treatments to osteoporotic populations. Mesenchymal stromal cell (MSC) transplantation as a therapeutic strategy for OP has not yet been examined in clinical trials. This may be attributed to the mixed findings of pre-clinical studies aimed at determining the efficacy of MSC therapy …
-
Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
Since decades, hematopoietic stem cell transplantation (HSCT) has become a well established treatment modality for hematological malignancies and non-malignant disorders. Autologous and allogeneic hematopoietic stem cells (HSCs) mobilized into the peripheral blood (PB) have been used as a preferred …
-
Advancing techniques for engineered tissue models of the bone marrow
Hematopoietic stem cells give rise to the blood and immune systems in organisms. These rare cells reside within the bone marrow and are the functional units of hematopoietic stem cell transplants, also known as bone marrow transplants. Methods to model the bone marrow and expand hematopoietic stem …
-
Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
Intestinal Mesenchymal stromal cells (fibroblasts, myofibroblasts and their progenitors) have recently emerged as key players in the interplay between the microbiota and professional immune cells under homeostasis and chronic inflammation. Initiation of microbial interactions with host cells, …
-
Keratin Microparticles for Drug and Cell Delivery
… are an intriguing delivery vehicle for drugs and cellular payloads for tissue engineering purposes due to the ability to exploit size, surface area, loading potential and importantly, non-invasive delivery (i.e. injection) of cells and biologics. Here we examine the water-in-oil emulsion synthesis …
-
In vitro evaluation of equine bone-marrow derived mesenchymal stromal cells to combat orthopedic biofilm infections
… other and are surrounded in a self-secreted extracellular matrix. The biofilm matrix protects the indwelling bacteria from being killed by antibiotics and the immune system. Biofilms also stimulate chronic inflammation and tissue destruction, including peri-implant osteolysis and subsequent …
-
Dietary regulation of myelopoiesis and stromal cell isolation
… chloride did not alter monocyte, granulocyte, T cell, B cell, or NK cell distributions in blood. In spleen, 10% sodium chloride did reduce the presence of NK cells but had minimal effect on other cell populations. In bone marrow, 10% sodium chloride increased the presence of T cells and both …
-
Novel intracellular signalling regulators of cartilage progenitor cell populations
… delivery of bone marrow and its constituent cell populations to the site of cartilage damage to form a regenerative clot have proved promising in repairing joint cartilage defects. In order to improve such regenerative technique, further research is required to provide a deeper understanding …
-
Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential
… GBM is its infiltrative growth. As the tumor cells leave the tumor bulk and migrate into the normal brain parenchyma, it is impossible to reach them with the current standard treatments. Hence, even after treatment, some tumor cells will remain in the brain and eventually give rise to a new …