Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 266 for “"mesenchymal stem cells"”.
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are tissue culture plastic adherent cells that are able to differentiate into multiple cell types, modulate the immune system, and aid in wound repair. These versatile cells are thus being investigated to treat a wide variety of different diseases such as graft vs. …
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Mesenchymal stem cells as trophic mediators of neural differentiation
… surrounds the rapidly-expanding field of stem cell research, owing to their high capacity for self-renewal and intrinsic ability to differentiate into mature cell lineages. Although it may be envisioned that embryonic stem cells will be of significantly greater therapeutic value than their …
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Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?
… none are aimed at preventing aneurysm formation. Mesenchymal stem cells are pluripotent cells that have interesting immunomodulatory properties and have been studied in the context of many inflammatory diseases. Few studies have addressed aneurysms and suggest that these cells have the potential …
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The Isolation and Differentiation of Adipose Derived Mesenchymal Stem Cells
… abundant and readily available source of adult mesenchymal stem cells (MSCs), resides within adipose tissue. Previous research has demonstrated that MSCs can differentiate into multiple specialized cell types and may thus be capable of ameliorating symptoms of many age-associated diseases. …
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Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas
Stem cells are one of the most fascinating areas of biology today, and since the discover of an adult population, i.e., adult Stem Cells (aSCs), they have generated much interest especially for their application potential as a source for cell based regenerative medicine and tissue engineering. aSCs …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… study, we investigated the effect of human mesenchymal stem cells (hMSCs) therapy in vitro and progressive SD rat model of PD using MG-132, proteasome inhibitor. Immunocytochemical analyses in primary mesencephalic culture revealed that hMSC treatment increased dopaminergic neuronal survival …
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Dicer loss induces an oncogenic epigenetic switch in mesenchymal stem cells
… the somatic state, we deleted Dicer in a murine mesenchymal stem cell model. Upon exploring the consequences of Dicer deletion, we identify a specific let-7 regulated mid-embryonic program within the global de-repression of miRNA targets accompanying Dicer loss. We further observe within the …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
Mesenchymal stem cells have demonstrated anti-inflammatory and immunomodulatory capabilities as well as modest efficacy in animal models of joint injury, warranting further study as a potential treatment of equine joint disease. The goal of the study is to investigate the inflammatory and immune …
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Regulatory Mechanisms Underlying the Differentiation of Mesenchymal Stem Cells to Endothelial Cells
… damaged endothelium. |Bone marrow (BM)-derived mesenchymal stem cells (MSCs) can differentiate into endothelial cells (ECs) in the presence of vascular endothelial growth factor (VEGF) — 165 in vitro. Translational models have demonstrated that differentiated BM-derived MSCs can be transplanted …
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A microparticle engineering approach to enhance the potency of mesenchymal stem cells
Cell-based therapies, which rely on transplanted cells to restore function to damaged tissues, are currently under investigation in clinical trials. Stem and progenitor cells, including mesenchymal stem cells (MSCs), have shown potential in pre-clinical models to treat diseases ranging from …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
Mesenchymal stem cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function …
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Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
… cytokines on tendon fibroblasts, adipose-derived mesenchymal stem cells: ASCs) were incorporated into the two in vitro models and their ability to modulate inflammation was investigated. While ASCs were unable to counteract the effects of IL-1β directly, ASC co-culture with macrophages …
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HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS (WJ-MSCs): CHARACTERIZATION AND PROPERTIES
In recent years, mesenchymal stem cells (MSCs) have attracted researchers’ attention because of their promising prospective and potential application in regenerative medicine. MSCs are defined as immature cells with the ability to self-renew and differentiate into specialized cells belonging to …
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
Mesenchymal stem cells, harvested from adult bone marrow, are promising in the field of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
"Mesenchymal stem cells (MSCs) are themselves capable of multi-potency, with differentiation under appropriate conditions into chondrocytes, skeletal myocytes, and neurons. MSCs have been also known to pose neuroprotective effects through secreting various cytotrophic factors. Based on our previous …
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Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells
… morphogenesis results from a complex series of mesenchymal-epithelial interactions and to date a method of generating de novo folliculogenesis from human cells has yet to be accomplished. Existing models rely on combining 'inductive’ dermal and 'receptive’ epithelial components and placing them …
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
Bone marrow (BM) mesenchymal stem cells (MSCs) form specialized perivascular microenvironments or niches in the BM that regulate hematopoietic stem cell (HSC) function. Interactions between MSC niche factors and HSCs ensure hematopoietic homeostasis. Vascular Cell Adhesion Molecule-1 (VCAM1) is …
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